Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Carla R Scanzello"'
Autor:
Nisha Sambamurthy, Cheng Zhou, Vu Nguyen, Ryan Smalley, Kurt D Hankenson, George R Dodge, Carla R Scanzello
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206217 (2018)
ObjectiveCD14 is a monocyte/macrophage pattern-recognition receptor that modulates innate inflammatory signaling. Soluble CD14 levels in knee OA synovial fluids are associated with symptoms and progression of disease. Here we investigate the role of
Externí odkaz:
https://doaj.org/article/cea5dc160def474cb8e174c4cb11ef18
Autor:
Joshua F. Baker, Marianna Olave, William Leach, Caleigh R. Doherty, Rachel L. Gillcrist, Daniel K. White, Alexis Ogdie, Bryant R. England, Katherine Wysham, Mercedes Quinones, Rui Xiao, Tuhina Neogi, Carla R. Scanzello
Publikováno v:
ACR Open Rheumatology, Vol 5, Iss 10, Pp 529-535 (2023)
Objective To quantify the effect of corticosteroids compared to lidocaine‐only injections over 12 weeks among patients with knee osteoarthritis (KOA). Methods Participants with KOA were randomized to receive a knee injection of methylprednisolone a
Externí odkaz:
https://doaj.org/article/1b48e8ad52744e149066a45eb0d65daa
Autor:
Sanique M. South, M. Caleb Marlin, Padmaja Mehta-D'souza, Tayte Stephens, Taylor Conner, Kevin G. Burt, Joel M. Guthridge, Carla R. Scanzello, Timothy M. Griffin
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 5, Iss 4, Pp 100416- (2023)
Objective: To develop an imaging mass cytometry method for identifying complex cell phenotypes, inter-cellular interactions, and population changes in the synovium and infrapatellar fat pad (IFP) of the mouse knee following a non-invasive compression
Externí odkaz:
https://doaj.org/article/9a6f8243865347f88ebe2d1ff564dc09
Autor:
Rahul Gawri, Yian Khai Lau, Gloria Lin, Snehal S. Shetye, Chenghao Zhang, Zhirui Jiang, Khaled Abdoun, Carla R. Scanzello, Stephanie Y. Jo, Wilfried Mai, George R. Dodge, Margret L. Casal, Lachlan J. Smith
Publikováno v:
Molecular Therapy - Methods & Clinical Development. 28:12-26
Mucopolysaccharidosis (MPS) VII is an inherited lysosomal storage disorder characterized by deficient activity of the enzyme β-glucuronidase. Skeletal abnormalities are common in patients and result in diminished quality of life. Enzyme replacement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b07d2a3cfdbef076d57cc2815ef579e
https://doi.org/10.1016/j.omtm.2022.11.006
https://doi.org/10.1016/j.omtm.2022.11.006
Autor:
Sophie C. Warner, Anjali Nair, Rahul Marpadga, Susan Chubinskaya, Michael Doherty, Ana M. Valdes, Carla R. Scanzello
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Objective: Interleukin-15 (IL-15) is a pro-inflammatory cytokine that is increased in joint fluids of early-stage osteoarthritis (OA) patients, and has been associated with expression of proteases that can damage cartilage, and the development of neu
Externí odkaz:
https://doaj.org/article/b0ff70926fd94398aa7df0528481e147
Publikováno v:
Journal of Inflammation Research. 15:2413-2424
Zuozhen Tian,1 Frances S Shofer,1,2 Alec Z Sandroni,1 Lan Zhao,3 Carla R Scanzello,4,5 Yejia Zhang1,6 1Department of Physical Medicine & Rehabilitation, Hospital of the University of Pennsylvania, Philadelphia, PA, USA; 2Department of Emergency Medic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a8f498b8044064cf80a440a3dca50e
https://doi.org/10.2147/jir.s355669
https://doi.org/10.2147/jir.s355669
Autor:
Terese Geraghty, Alia M. Obeidat, Shingo Ishihara, Matthew J. Wood, Jun Li, Erika Barboza Prado Lopes, Carla R. Scanzello, Timothy M. Griffin, Anne-Marie Malfait, Rachel E. Miller
ObjectiveOsteoarthritis (OA) is a leading cause of chronic pain, yet OA pain management remains poor. Age is the strongest predictor of OA development, and mechanisms driving OA pain are unclear. While injury-induced OA models are useful, only a subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::160a580a33713d4d7ce5d059d6c77103
https://doi.org/10.1101/2022.07.07.499172
https://doi.org/10.1101/2022.07.07.499172
Autor:
William Leach, Caleigh Doherty, Marianna Olave, Bryant R. England, Katherine Wysham, Gail Kerr, Mercedes Quinones, Alexis Ogdie, Dan White, Tuhina Neogi, Carla R. Scanzello, Joshua F. Baker
Publikováno v:
Trials. 23(1)
Background Knee osteoarthritis (KOA) is a high-priority problem among the aging population. While exercise has been shown to be beneficial in management of the disease, scalable and low-cost interventions to improve exercise in this population are la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b022500a5823722c717bc56ec1e933fe
https://pubmed.ncbi.nlm.nih.gov/35897080
https://pubmed.ncbi.nlm.nih.gov/35897080
Autor:
Di Chen, Jian Huang, Carla R. Scanzello, Flavia Vitale, Frances S. Shofer, Julie Michelle Brent, Zuozhen Tian, Yejia Zhang, Ling Qin, Lutian Yao, Angela K Brice, Dessislava Markova
Publikováno v:
Comp Med
We showed previously that inflammatory mediators, including IL8, in intervertebral disc tissues from patients with discogenic back pain may play a key role in back pain. To investigate the molecular mechanism of IL8 signaling in back pain, we generat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f392ab6d409d3e65c97542c82d337828
https://doi.org/10.30802/aalas-cm-19-000049
https://doi.org/10.30802/aalas-cm-19-000049
Autor:
Chenghao Zhang, Rahul Gawri, Yian Khai Lau, Lynn A. Spruce, Hossein Fazelinia, Zhirui Jiang, Stephanie Y. Jo, Carla R. Scanzello, Wilfried Mai, George R. Dodge, Margret L. Casal, Lachlan J. Smith
Publikováno v:
Molecular Genetics and Metabolism. 138:107371
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9aae9657fac502ece8fa5982c8787f0a
https://doi.org/10.1016/j.ymgme.2023.107371
https://doi.org/10.1016/j.ymgme.2023.107371