Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Carla Picklesimer"'
Autor:
Sundar Jagannath, Luciano J. Costa, Cassandra Choe-Juliak, A. Keith Stewart, Divaya Bhutani, Ravi Vij, Jeffrey A. Zonder, Jean Richard Saint-Martin, Dan T. Vogl, Craig E. Cole, David Dingli, Rafat Abonour, Michael Kauffman, Rafael Fonseca, Ajay K. Nooka, Sharon Shacham, Terri L. Parker, Robert F. Cornell, Rachid Baz, James E. Hoffman, David Kaminetzky, David S. Siegel, Andrew Yee, Gregory J. Ahmann, Carla Picklesimer, Ilsel Lopez, Joshua R. Richter, Ajai Chari, Carol Ann Huff, Andrzej Jakubowiak, Gary J. Schiller, Scott Van Wier
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol 36, iss 9
Purpose Selinexor, a first-in-class, oral, selective exportin 1 (XPO1) inhibitor, induces apoptosis in cancer cells through nuclear retention of tumor suppressor proteins and the glucocorticoid receptor, along with inhibition of translation of oncopr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a8485966f48847a486acafd4f0bd10
https://doi.org/10.1200/jco.2017.75.5207
https://doi.org/10.1200/jco.2017.75.5207
Autor:
Laurent Frenzel, Aurore Perrot, David Dingli, Philippe Moreau, James E. Hoffman, Lingling Li, Luciano J. Costa, Sascha Tuchman, Mohamad Mohty, Sylvain Choquet, Thomas Illmer, Yosef Landesman, Paul G. Richardson, Ravi Vij, S. Lonial, Andrew Yee, Dan T Vogl, Marc S Raab, Meletios A. Dimopoulos, Carol Ann Huff, Terri L. Parker, Maria Gavriatopoulou, Moshe Yair Levy, Samir Parekh, Sundar Jagannath, Jean-Richard Saint-Martin, Ajai Chari, Raymond L Comenzo, Klaus Podar, Katja Weisel, Thierry Facon, Hua Chang, A. Keith Stewart, Marsha Crochiere, Nathalie Meuleman, Chantal Doyen, Carla Picklesimer, Monika Engelhardt, Philip Vlummens, Martin Schreder, Shijie Tang, Robert F Cornell, Lionel Karlin, Gary J. Schiller, Craig E. Cole, Ajay K. Nooka, David Kaminetzky, Michel Delforge, Jatin Shah, Michael Kauffman, Sharon Shacham, Joshua Richter
Publikováno v:
The New England journal of medicine, 381 (8
The New England journal of medicine, Vol. 381, no.8, p. 727-738 (2019)
The New England journal of medicine, Vol. 381, no.8, p. 727-738 (2019)
Selinexor, a selective inhibitor of nuclear export compound that blocks exportin 1 (XPO1) and forces nuclear accumulation and activation of tumor suppressor proteins, inhibits nuclear factor κB, and reduces oncoprotein messenger RNA translation, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e93fa85bbd4ab7ec463480fc105d95a1
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/302970
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/302970
Autor:
Sascha A. Tuchman, Sundar Jagannath, Lingling Li, Luciano J. Costa, Moshe Yair Levy, Philippe Moreau, A. Keith Stewart, Paul G. Richardson, Josh Richter, Laurent Frenzel, Katja Weisel, Ravi Vij, David Dingli, Martin Schreder, Michel Delforge, Terri L. Parker, James E. Hoffman, Nathalie Meuleman, Sylvain Choquet, Ajai Chari, Jatin P. Shah, Craig E. Cole, Jean-Richard Saint-Martin, Ajay K. Nooka, Maria Gavriatopoulou, Meletios-Athanasios Dimopoulos, Carol Ann Huff, Robert F. Cornell, Andrew Yee, Sharon Shacham, David Kaminetzky, Dan T. Vogl, Mohmad Mohty, Carla Picklesimer, Kelly N. Godby, Michael Kauffman, Marc-Steffen Raab
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 18:S249-S250
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00ced84add1687f468d8cb1b7caf58ca
https://doi.org/10.1016/j.clml.2018.07.149
https://doi.org/10.1016/j.clml.2018.07.149
Autor:
Michael Kauffman, David Dingli, Jatin P. Shah, Maria Gavriatopoulou, Luciano J. Costa, Chantal Doyen, Andrew Yee, Meletios A. Dimopoulos, Jean-Richard Saint-Martin, James E. Hoffman, David S. Siegel, Noa Biran, Sascha A. Tuchman, Philippe Moreau, Sundar Jagannath, Ravi Vij, Lingling Li, Carla Picklesimer, Philip Vlummens, Paul G. Richardson, Dan T. Vogl, Carol Ann Huff, Ajai Chari, Terri L. Parker, Joshua Richter, Craig E. Cole, Sharon Shacham, Ajay K. Nooka, Sagar Lonial
Publikováno v:
Blood. 134:3140-3140
Introduction: Selinexor is a first-in-class Selective Inhibitor of Nuclear Export (SINE) compound that selectively binds and inactivates XPO1, therefore forcing the nuclear retention and re-activation of cell cycle regulators such as p53, FOXO, IkB,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::026be180a5a8a6b3d91f6fca34c53065
https://doi.org/10.1182/blood-2019-129038
https://doi.org/10.1182/blood-2019-129038
Autor:
James E. Hoffman, Philippe Moreau, Martin Schreder, Paul G. Richardson, Sundar Jagannath, Ravi Vij, Robert F. Cornell, Laurent Frenzel, Lingling Li, Nathalie Meuleman, Craig E. Cole, Meletios A. Dimopoulos, Jatin J. Shah, Sascha A. Tuchman, Ajay K. Nooka, Dan T. Vogl, Maria Gavriatopoulou, David Dingli, Kelly N. Godby, Moshe Yair Levy, Marc S. Raab, A. Keith Stewart, David Kaminetzky, Luciano J. Costa, Carla Picklesimer, Andrew Yee, Carol Ann Huff, Terri L. Parker, Mohamad Mohty, Ajai Chari, Michel Delforge, Choquet Sylvain, Katja Weisel, Sharon Shacham, Jean-Richard Saint-Martin, Joshua Richter, Michael Kauffman
Publikováno v:
Blood. 132:598-598
Introduction: Selinexor is a novel, oral Selective Inhibitor of Nuclear Export (SINE) compound that blocks exportin 1 (XPO1). Selinexor treatment results in nuclear accumulation and activation of tumor suppressor proteins, inhibition of NF-kB, and tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3356258b237c6e9938ff0bfea9c23fc
https://doi.org/10.1182/blood-2018-99-116663
https://doi.org/10.1182/blood-2018-99-116663
Autor:
Carol Ann Huff, Gregory J. Ahmann, Carla Picklesimer, Cassandra Choe-Juliak, Joshua R. Richter, Ajai Chari, Rachid Baz, Sharon Shacham, James E. Hoffman, Jean-Richard Saint-Martin, Ilsel Lopez, Terri L. Parker, David S. Siegel, Scott VanWier, Craig E. Cole, A. Keith Stewart, Rafael Fonseca, Ajay K. Nooka, R. Frank Cornell, David Kaminetzky, Andrew Yee, Sundar Jagannath, Andrzej Jakubowiak, Ravi Vij, Luciano J. Costa, Sharon Friedlander, Michael Kauffman, David Dingli, Rafat Abonour, Gary J. Schiller, Dan T. Vogl, Divaya Bhutani
Publikováno v:
Blood. 128:491-491
Introduction - With over 12,000 deaths from MM anticipated in 2016, nearly all patients (pts) with multiple myeloma (MM) will become "quad refractory" to IMIDs (lenalidomide and pomalidomide) and proteasome inhibitors (bortezomib and carfilzomib), an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4a120121ffb455f936d89151df280b9
https://doi.org/10.1182/blood.v128.22.491.491
https://doi.org/10.1182/blood.v128.22.491.491
Autor:
Tom Kouroukis, Aldo Del Col, Christopher P. Venner, Jacqueline Jeha, Marc Lalancette, Cassandra Choe-Juliak, Heather J. Sutherland, Debra Bergstrom, Sharon Shacham, Carla Picklesimer, Michael Kauffman, Nizar J. Bahlis, Rami Kotb, Suzanne Lentzsch, Richard Leblanc, William I. Bensinger, Darrell White, Christine Chen, Michael Sebag, Jean-Richard Saint-Martin, Arleigh McCurdy
Publikováno v:
Blood. 128:977-977
Introduction - Selinexor is a first-in-class Selective Inhibitor of Nuclear Export (SINE) compound that binds and inactivates Exportin 1 (XPO1). Selinexor with low dose dexamethasone (dex) has demonstrated potent anti-cancer activity in patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eae159dc63692c557ab59f949834822a
https://doi.org/10.1182/blood.v128.22.977.977
https://doi.org/10.1182/blood.v128.22.977.977