Výsledky vyhledávání - "Carla O. Rosario"

Exploring the geriatric needs of oncology inpatients at an academic cancer centre

Autor: Shabbir M.H. Alibhai, Raymond Woo-Jun Jang, Daniel Yokom, Andrea Bezjak, Martine Puts, Carla O. Rosario

Publikováno v: Journal of geriatric oncology. 10(5)

Purpose Geriatric Assessments (GAs) in older adults with cancer have informed treatment decision-making and refined survival prediction. However, little is known about the needs of older inpatients with cancer. Our objectives were to test the feasibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84432cd7ec63a028b0257bee4c926283
https://pubmed.ncbi.nlm.nih.gov/30587462

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Meeting the needs of the aging population: the Canadian Network on Aging and Cancer—report on the first Network meeting, 27 April 2016

Autor: Ewa Szumacher, S. Alibhai, Tina Hsu, Hyman B. Muss, Supriya G. Mohile, Carla O. Rosario, Etienne Brain, Samar Toubasi, Caroline Mariano, Camilla L. Wong, D. Wan-Chow-Wah, Martine Puts, Maureen E. Trudeau, Schroder Sattar, W. Duggleby

The aging of the Canadian population represents the major risk factor for a projected increase in cancer incidence in the coming decades. However, the evidence base to guide management of older adults with cancer remains extremely limited. It is thus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca5ab3f85b2178d1fc1436bfe6ac4b1
https://europepmc.org/articles/PMC5407881/

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Delirium incidence, risk factors, and treatment in older adults receiving chemotherapy: A scoping review

Autor: Roger Reka, Carla O. Rosario, Zuhair Alam, Lily Yeung, Leigha Rowbottom, Patrick Jung, Ali Taqi Syed, Shabbir M.H. Alibhai, Daniel Yokom, Ana Patricia Ayala, Uzair Malik, Martine Puts

Publikováno v: Journal of Clinical Oncology. 37:e23025-e23025

e23025 Background: Older adults with cancer are at increased risk of delirium given their advanced age, multiple comorbidities and medications, prevalence of cognitive impairment, and possibly cancer treatment. Awareness of such risks and interventio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e902af75eb7e1bc09f7158f41e83f4ef
https://doi.org/10.1200/jco.2019.37.15_suppl.e23025

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Nucleolar release of Hand1 acts as a molecular switch to determine cell fate

Autor: Catherine A. Risebro, Carol J. Swallow, Nicola Smart, David M. J. Martindill, Carla O. Rosario, James W. Dennis, Paul R. Riley, Maria Del Mar Franco-Viseras

The bHLH transcription factor Hand1 is essential for placentation and cardiac morphogenesis in the developing embryo. Here we implicate Hand1 as a molecular switch that determines whether a trophoblast stem cell continues to proliferate or commits to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c5226baf9e88978c2ece9dabd41b90
https://doi.org/10.1038/ncb1633

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Plk4 is required for cytokinesis and maintenance of chromosomal stability

Autor: Yosr Z. Haffani, Aaron Pollett, Carol J. Swallow, Carla O. Rosario, Jana Paderova, Rebecca A. Gladdy, Michael A. Ko, Jeremy A. Squire, James W. Dennis

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 107(15)

Aneuploidy is a characteristic feature of established cancers and can promote tumor development. Aneuploidy may arise directly, through unequal distribution of chromosomes into daughter cells, or indirectly, through a tetraploid intermediate. The pol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684101c5819261c293465afbfa0a497e
https://pubmed.ncbi.nlm.nih.gov/20348415

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Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis

Autor: Carla O. Rosario, Michael A. Ko, John W. Hudson, Carol J. Swallow, James W. Dennis, Aaron Pollett, Sarang Kulkarni

Publikováno v: Biological Sciences Publications

The polo-like kinase Plk4 (also called Sak) is required for late mitotic progression, cell survival and postgastrulation embryonic development. Here we identified a phenotype resulting from Plk4 haploinsufficiency in Plk4 heterozygous cells and mice.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e17187d2576160656242d0179f01f6c0
https://scholar.uwindsor.ca/biologypub/672

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Polo-like Kinase 4 (Plk4) enhances cancer cell motility via RhoGTPase activation

Autor: Olga Brashavitskaya, Francis Si Wai Zih, Carol J. Swallow, Karineh Kazazian, Carla O. Rosario

Publikováno v: Journal of the American College of Surgeons. 215:S129-S130

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c41206f264e7e9d5c50d5e62c7ae57ba
https://doi.org/10.1016/j.jamcollsurg.2012.06.335

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Polo-like kinase 4 (Plk4) promotes cancer cell invasion

Autor: Francis S. W. Zih, Roland Xu, Karineh Kazazian, Carol J. Swallow, Carla O. Rosario

Publikováno v: Journal of the American College of Surgeons. 217:S128

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14c3047249a580633ca3e91312339cc8
https://doi.org/10.1016/j.jamcollsurg.2013.07.297

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Abstract 4045: Hypoxia induces Plk4 expression and promotes immortalization of proliferating cells

Autor: Carla O. Rosario, Carol J. Swallow

Publikováno v: Cancer Research. 73:4045-4045

Introduction: Polo-like kinase 4 (Plk4) is a serine/threonine kinase essential for centrosome duplication and cell cycle progression.High tumor expression of Plk4 is associated with poor prognosis in breast, pancreas and colorectal cancer patients. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17facad3cce056200a99afd3e2e3c399
https://doi.org/10.1158/1538-7445.am2013-4045

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