Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Carla Mulas"'
Autor:
Timo N. Kohler, Joachim De Jonghe, Anna L. Ellermann, Ayaka Yanagida, Michael Herger, Erin M. Slatery, Antonia Weberling, Clara Munger, Katrin Fischer, Carla Mulas, Alex Winkel, Connor Ross, Sophie Bergmann, Kristian Franze, Kevin Chalut, Jennifer Nichols, Thorsten E. Boroviak, Florian Hollfelder
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Biomechanical cues are instrumental in guiding embryonic development and cell differentiation. Understanding how these physical stimuli translate into transcriptional programs will provide insight into mechanisms underlying mammalian pre-imp
Externí odkaz:
https://doaj.org/article/19d37a4e6ae24ca8b14f83a6a064a669
Autor:
Céline Labouesse, Bao Xiu Tan, Chibeza C. Agley, Moritz Hofer, Alexander K. Winkel, Giuliano G. Stirparo, Hannah T. Stuart, Christophe M. Verstreken, Carla Mulas, William Mansfield, Paul Bertone, Kristian Franze, José C. R. Silva, Kevin J. Chalut
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The independent control of substrate stiffness and tethering of extracellular matrix to substrates for mechanical signalling investigations remains challenging. Here the authors present StemBond hydrogels, with stable ECM tethering that can be varied
Externí odkaz:
https://doaj.org/article/2711320dd2f24be2b2c8cdd0355b3ae1
Autor:
Hisham Mohammed, Irene Hernando-Herraez, Aurora Savino, Antonio Scialdone, Iain Macaulay, Carla Mulas, Tamir Chandra, Thierry Voet, Wendy Dean, Jennifer Nichols, John C. Marioni, Wolf Reik
Publikováno v:
Cell Reports, Vol 20, Iss 5, Pp 1215-1228 (2017)
Summary: The mouse inner cell mass (ICM) segregates into the epiblast and primitive endoderm (PrE) lineages coincident with implantation of the embryo. The epiblast subsequently undergoes considerable expansion of cell numbers prior to gastrulation.
Externí odkaz:
https://doaj.org/article/0188c92fe17348f8a895182d37e67690
Publikováno v:
Stem Cell Reports, Vol 9, Iss 1, Pp 77-91 (2017)
Naive mouse embryonic stem cells (ESCs) can develop multiple fates, but the cellular and molecular processes that enable lineage competence are poorly characterized. Here, we investigated progression from the ESC ground state in defined culture. We u
Externí odkaz:
https://doaj.org/article/f709d1fb088f42439e6122f321d4fff3
Publikováno v:
Stem Cell Reports
Detailed studies of the embryo allow an increasingly mechanistic understanding of development, which has proved of profound relevance to human disease. The last decade has seen in vitro cultured stem cell-based models of embryo development flourish,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326d3b2d4d05639521142e70a0728292
https://doi.org/10.1016/j.stemcr.2021.03.019
https://doi.org/10.1016/j.stemcr.2021.03.019
Autor:
Timo N. Kohler, Joachim De Jonghe, Anna L. Ellerman, Ayaka Yanagida, Michael Herger, Erin M. Slatery, Katrin Fischer, Carla Mulas, Alex Winkel, Connor Ross, Sophie Bergmann, Kristian Franze, Kevin Chalut, Jennifer Nichols, Thorsten E. Boroviak, Florian Hollfelder
Biomechanical cues are instrumental in guiding embryonic development and cell differentiation. Understanding how these physical stimuli translate into transcriptional programs could provide insight into mechanisms underlying mammalian pre-implantatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c741f38e1670e171ebf6a355c63c9f57
https://doi.org/10.1101/2022.03.13.484158
https://doi.org/10.1101/2022.03.13.484158
Autor:
Bao Xiu Tan, Céline Labouesse, Carla Mulas, Alexander K. Winkel, Moritz Hofer, Christophe M. Verstreken, Chibeza C. Agley, Kevin J. Chalut, José C. R. Silva, Giuliano Giuseppe Stirparo, Paul Bertone, Kristian Franze, William Mansfield, Hannah T. Stuart
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Funder: Medical Research Council (UK) Career Development Award (G1100312/1)
Funder: Medical Research Council (UK) MR/M011089/1 Wellcome Trust-Medical Research Council core funding to the Wellcome-MRC Cambridge Stem Cell Institute
Studies of
Funder: Medical Research Council (UK) MR/M011089/1 Wellcome Trust-Medical Research Council core funding to the Wellcome-MRC Cambridge Stem Cell Institute
Studies of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79db56a2eb87774cd06d0a784eb5336e
https://www.repository.cam.ac.uk/handle/1810/329719
https://www.repository.cam.ac.uk/handle/1810/329719
Publikováno v:
Development. 148
A fundamental challenge when studying biological systems is the description of cell state dynamics. During transitions between cell states, a multitude of parameters may change – from the promoters that are active, to the RNAs and proteins that are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb19fa03a6ec604e6d9b5fe1c51ce3ae
https://doi.org/10.1242/dev.199950
https://doi.org/10.1242/dev.199950
Autor:
Carla Mulas, Chibeza C. Agley, Florian Hollfelder, Andrew C Hodgson, Timo N Kohler, Kevin J. Chalut, Austin Smith
Publikováno v:
bioRxiv
Combining live imaging with the ability to retrieve individual cells of interest remains a technical challenge. These combined methods are of particular interest when studying highly dynamic or transient, asynchronous or heterogeneous cell biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e96a196e91e82085e32a24809dea2e
https://doi.org/10.1101/2020.02.17.952689
https://doi.org/10.1101/2020.02.17.952689
Autor:
Carla Mulas, Chibeza C. Agley, Kevin J. Chalut, Peter Humphreys, Hans Kleine-Brüggeney, Andrew C Hodgson, Austin Smith, Timo N Kohler, Florian Hollfelder
Publikováno v:
Lab on a Chip
Combining live imaging with the ability to retrieve individual cells of interest remains a technical challenge. Combining imaging with precise cell retrieval is of particular interest when studying highly dynamic or transient, asynchronous, or hetero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b29c74c50cb18b4db5a03d44447718