Výsledky vyhledávání - "Carla Mouta-Bellum"

Notch2 Signaling Induces Apoptosis and Inhibits Human MDA-MB-231 Xenograft Growth

Autor: Christina Cinelli, Jessica L. Toher, Alexis Lincoln, Robert J. Nadeau, Ruth G. Leon, Carla Mouta-Bellum, Robert Friesel, Christine F. O'Neill, Lucy Liaw, Sumithra Urs

Publikováno v: The American Journal of Pathology. 171:1023-1036

Notch functions as an oncogene or tumor inhibitor in various cancers, and decreases in Notch2 expression are associated with increasing grade of human breast cancer. We constitutively activated Notch signaling with intracellular domain (ICD) expressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c887b7fd18ba2f7f86b287495f08db48
https://doi.org/10.2353/ajpath.2007.061029

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Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85α, p55α, and p50α

Autor: Maria Cecilia Mancini, Lewis C. Cantley, Philip E. Thorpe, Carla Mouta-Bellum, Lucy Liaw, Igor Prudovsky, Tatiana Petrova, David A. Fruman, Naoyuki Miura, Calvin P.H. Vary, Laura Miceli-Libby, Aleksander Kirov, Kari Alitalo

Publikováno v: Developmental Dynamics, vol. 238, no. 10, pp. 2670-2679

The phosphoinositide 3-kinase (PI3K) family has multiple vascular functions, but the specific regulatory isoform supporting lymphangiogenesis remains unidentified. Here, we report that deletion of the Pik3r1 gene, encoding the regulatory subunits p85

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad66e8f19fd069ad79a9fe1b41e41827
https://europepmc.org/articles/PMC2826787/

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Novel cross-talk between three cardiovascular regulators: thrombin cleavage fragment of Jagged1 induces fibroblast growth factor 1 expression and release

Autor: Deena Small, Robert Friesel, Joseph M. Verdi, Aleksandr Kirov, Raffaella Soldi, Igor Prudovsky, Doreen Kacer, Carla Mouta-Bellum, Maria F. Duarte, Lucy Liaw, Irene Graziani, Vihren Kolev, Thomas Maciag

Publikováno v: Molecular biology of the cell. 19(11)

Angiogenesis is controlled by several regulatory mechanisms, including the Notch and fibroblast growth factor (FGF) signaling pathways. FGF1, a prototype member of FGF family, lacks a signal peptide and is released through an endoplasmic reticulum–

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70183f34dd26bd0a97f84b79fcbbef77
https://pubmed.ncbi.nlm.nih.gov/18784255

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