Výsledky vyhledávání - "Carla Maria Ramos C.M. Germano"

Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress-Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis

Autor: Lorella Marselli, Daniel Andrade Da Cunha, Chantal Mathieu, Conny Gysemans, Decio L. Eizirik, Najib Naamane, Piero Marchetti, David Ron, Carla Maria Ramos C.M. Germano, Jean-Marie Vanderwinden, Mariana Igoillo-Esteve, Esteban Nicolas Gurzov, Ihsane Marhfour, Makiko Fukaya, Heather P. Harding, Miriam Cnop

Publikováno v: Diabetes
Diabetes (New York, N.Y.), 61 (11

Environmental factors such as diets rich in saturated fats contribute to dysfunction and death of pancreatic β-cells in diabetes. Endoplasmic reticulum (ER) stress is elicited in β-cells by saturated fatty acids. Here we show that palmitate-induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29a67a877b9bf77f1a8e7af91175467d
https://lirias.kuleuven.be/handle/123456789/669544

Zobrazit plný text záznamu

Cytokines Tumor Necrosis Factor-a and Interferon-? Induce Pancreatic ß-Cell Apoptosis through STAT1-mediated Bim Protein Activation

Autor: Fabrice Moore, Decio L. Eizirik, Daniel J. Drucker, Piero Marchetti, Adriano Maida, Esteban Nicolas Gurzov, Gabriel Núñez, Conny Gysemans, Jenny Barthson, Chantal Mathieu, Andrea Jurisicova, Carla Maria Ramos C.M. Germano

Publikováno v: The Journal of biological chemistry, 286 (45

Type 1 diabetes is characterized by local inflammation (insulitis) in the pancreatic islets causing β-cell loss. The mitochondrial pathway of apoptosis is regulated by the balance and interaction between Bcl-2 members. Here we clarify the molecular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c53c0bfde60f0758e042a5093bd6a4
http://hdl.handle.net/11568/148517

Zobrazit plný text záznamu

p53 Up-regulated Modulator of Apoptosis (PUMA) Activation Contributes to Pancreatic β-Cell Apoptosis Induced by Proinflammatory Cytokines and Endoplasmic Reticulum Stress*

Autor: Lin Zhang, Esteban Nicolas Gurzov, Decio L. Eizirik, Daniel Andrade Da Cunha, Fernanda Ortis, Piero Marchetti, Jean-Marie Vanderwinden, Carla Maria Ramos C.M. Germano

Publikováno v: The Journal of biological chemistry, 285 (26

Type 1 diabetes is an autoimmune disorder characterized by chronic inflammation and pancreatic β-cell loss. Here, we demonstrate that the proinflammatory cytokine interleukin-1β, combined with interferon-γ, induces the expression of the Bcl-2 homo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73d83071f20e68ca2cc4e6182df4c85
https://europepmc.org/articles/PMC2888402/

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání