Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Carla Maciag"'
Autor:
Francesco G. Salituro, Gabriel Martinez Botella, James J. Doherty, Rebecca S. Hammond, Alison L. Althaus, Carla Maciag, Albert J. Robichaud, Michael A. Ackley
Publikováno v:
Epilepsy Research. 134:16-25
Despite the availability of multiple antiepileptic drugs (AED), failure to adequately control seizures is a challenge for approximately one third of epilepsy patients, and new therapies with a differentiated mechanism of action are needed. The neuroa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ebdf33e1a2544115114f31f08ce039
https://doi.org/10.1016/j.eplepsyres.2017.05.001
https://doi.org/10.1016/j.eplepsyres.2017.05.001
Autor:
Thomas J. Hudzik, Michael W. Wood, Carla Maciag, Jianwei Liu, S. Nyberg, Alan J. Cross, Dan Widzowski, Anna Zacco
Publikováno v:
British Journal of Pharmacology. 173:155-166
BACKGROUND AND PURPOSE Quetiapine has a range of clinical activity distinct from other atypical antipsychotic drugs, demonstrating efficacy as monotherapy in bipolar depression, major depressive disorder and generalized anxiety disorder. The neuropha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98125f8b119524f3357ca292b11a7b93
https://doi.org/10.1111/bph.13346
https://doi.org/10.1111/bph.13346
Autor:
Adam Jeston Dudley, Joanne Smolka, Carla Maciag, Chapdelaine Marc, Michael Quirk, Wei Song, Farzin Gharahdaghi, Xiaodong F. Liu, Maria Ribadeneira, Donna L. Maier, Jeffrey L. Arriza, Dean H. Snyder, James J. Doherty, Maninder Chopra, Min Ding, David Gurley, Edward P. Christian
Publikováno v:
Journal of Neurophysiology. 113:116-131
Benzodiazepine drugs, through interaction with GABAAα1, GABAAα2,3, and GABAAα5 subunits, modulate cortical network oscillations, as reflected by a complex signature in the EEG power spectrum. Recent drug discovery efforts have developed GABAAα2,3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b230ce60a550bef457160844275d07
https://doi.org/10.1152/jn.00539.2013
https://doi.org/10.1152/jn.00539.2013
Autor:
Erica M. Richards, Mark A. Smith, Carla Maciag, Neal M. Nolan, Carlos A. Zarate, Rodrigo Machado-Vieira, Shuang Li, Jose A. Franco-Chaves, Wallace C. Duncan, Mark J. Niciu, Daniel C. Mathews, Thomas J. Hudzik, David A. Luckenbaugh, Alan J. Cross, Dawn F. Ionescu
Patients with anxious major depressive disorder (AMDD) have more severe symptoms and poorer treatment response than patients with non-AMDD. Increasing evidence implicates the endogenous opioid system in the pathophysiology of depression. AZD2327 is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13acf04e0e35e34972be5ea293bf0c51
https://europepmc.org/articles/PMC5103283/
https://europepmc.org/articles/PMC5103283/
Autor:
Linda C. Litwin, John C. Gordon, Anna Zacco, Carla Maciag, Timothy Piser, Todd Andrew Brugel, Carolann Thompson, Linda A. Sygowski, Matthew F. Peters, Patricia Schroeder
Publikováno v:
European Journal of Pharmacology. 661:27-34
The κ-opioid receptor plays a central role in mediating the response to stressful life events. Inhibiting κ-opioid receptor signaling is proposed as a mechanism for treating stress-related conditions such as depression and anxiety. Preclinical test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f212aa26221789ed8dcadd08031d4557
https://doi.org/10.1016/j.ejphar.2011.04.017
https://doi.org/10.1016/j.ejphar.2011.04.017
Autor:
Michael W. Wood, Dean G. Brown, Shephali Trivedi, Don Mathisen, Mark Sylvester, Xia Wang, John C. Roberts, Zuozhong Peng, Tao Hu, Tiffany N. Hoerter, Magnus Johansson, Donna L. Maier, Tongming Chen, Jennifer R. Krumrine, Ji Jiang, Carla Maciag, Lee T. Hirata, Celina C. Lasota, Anshul Gupta, Deidre E. Wilkins, Frank Liu, Jian Xia, Charles S. Elmore, Evelynjeane J. Sutton, Xiaoping Wang, James B. Campbell, Jerry Cumberledge, Cristobal Alhambra, Dennis J. McCarthy, Elnaz Menhaji-Klotz, Jian Wang, Xiaotian Wen, Paul J. Ciaccio, Clay W Scott
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3399-3403
Herein we describe the discovery of compounds that are competitive antagonists of the CP101-606 binding site within the NR2B subtype of the NMDA receptor. The compounds identified do not possess phenolic functional groups such as those in ifenprodil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39e7b2fa51a028f86ba5dd6fd91511b
https://doi.org/10.1016/j.bmcl.2011.03.117
https://doi.org/10.1016/j.bmcl.2011.03.117
Autor:
E.J. Sutton, Dan Widzowski, Ladislav Mrzljak, Carla Maciag, James J. Doherty, Dekun Song, Chaoying Li, Yi Wang, Thomas J. Hudzik, Michael Quirk, Simon Sydserff, David Gurley, Jeffrey S. Smith, John C. Gordon, Gennady N. Smagin, Edwin C. Johnson, Tim Piser, Edward P. Christian, Gerald Jonak
Publikováno v:
Biochemical pharmacology. 78(7)
AZD0328, a novel spirofuropyridine neuronal nicotinic receptor partial agonist, was used to investigate the role of alpha7 neuronal nicotinic receptor (NNR) activation in the modulation of midbrain dopamine neuron function, cortical dopamine release
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ee8a3e1b4629fbdf9688d4876f742a
https://pubmed.ncbi.nlm.nih.gov/19615981
https://pubmed.ncbi.nlm.nih.gov/19615981