Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Carla M. Mann"'
Autor:
Wesley A Wierson, Jordan M Welker, Maira P Almeida, Carla M Mann, Dennis A Webster, Melanie E Torrie, Trevor J Weiss, Sekhar Kambakam, Macy K Vollbrecht, Merrina Lan, Kenna C McKeighan, Jacklyn Levey, Zhitao Ming, Alec Wehmeier, Christopher S Mikelson, Jeffrey A Haltom, Kristen M Kwan, Chi-Bin Chien, Darius Balciunas, Stephen C Ekker, Karl J Clark, Beau R Webber, Branden S Moriarity, Stacy L Solin, Daniel F Carlson, Drena L Dobbs, Maura McGrail, Jeffrey Essner
Publikováno v:
eLife, Vol 9 (2020)
Efficient precision genome engineering requires high frequency and specificity of integration at the genomic target site. Here, we describe a set of resources to streamline reporter gene knock-ins in zebrafish and demonstrate the broader utility of t
Externí odkaz:
https://doaj.org/article/753d782fc25e478bab0a05b01b9d9f77
Autor:
Maxim Zvyagin, Alexander Brace, Kyle Hippe, Yuntian Deng, Bin Zhang, Cindy Orozco Bohorquez, Austin Clyde, Bharat Kale, Danilo Perez-Rivera, Heng Ma, Carla M. Mann, Michael Irvin, J. Gregory Pauloski, Logan Ward, Valerie Hayot-Sasson, Murali Emani, Sam Foreman, Zhen Xie, Diangen Lin, Maulik Shukla, Weili Nie, Josh Romero, Christian Dallago, Arash Vahdat, Chaowei Xiao, Thomas Gibbs, Ian Foster, James J. Davis, Michael E. Papka, Thomas Brettin, Rick Stevens, Anima Anandkumar, Venkatram Vishwanath, Arvind Ramanathan
We seek to transform how new and emergent variants of pandemiccausing viruses, specifically SARS-CoV-2, are identified and classified. By adapting large language models (LLMs) for genomic data, we build genome-scale language models (GenSLMs) which ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb3062847bc49934d638fc48a21a278
https://doi.org/10.1101/2022.10.10.511571
https://doi.org/10.1101/2022.10.10.511571
Autor:
Hirotaka Ata, Thomas L Ekstrom, Gabriel Martínez-Gálvez, Carla M Mann, Alexey V Dvornikov, Kyle J Schaefbauer, Alvin C Ma, Drena Dobbs, Karl J Clark, Stephen C Ekker
Publikováno v:
PLoS Genetics, Vol 14, Iss 9, p e1007652 (2018)
One key problem in precision genome editing is the unpredictable plurality of sequence outcomes at the site of targeted DNA double stranded breaks (DSBs). This is due to the typical activation of the versatile Non-homologous End Joining (NHEJ) pathwa
Externí odkaz:
https://doaj.org/article/c85c3d9fa6a447a88aba7e6859d8e799
Autor:
Brandon W. Simone, Stephen C. Ekker, Karl J. Clark, Drena Dobbs, Michael A. Barry, Michael J. Emch, Jordan M. Welker, William A.C. Gendron, Iddo Friedberg, Zachary WareJoncas, Bibekananda Kar, Jeffrey J. Essner, Wesley A. Wierson, Carla M. Mann, Maura McGrail
Publikováno v:
The CRISPR Journal
CRISPR and CRISPR-Cas effector proteins enable the targeting of DNA double-strand breaks to defined loci based on a variable length RNA guide specific to each effector. The guide RNAs are generally similar in size and form, consisting of a ∼20 nucl
Autor:
Maira P. Almeida, Carla M. Mann, Zhitao Ming, Maura McGrail, Karl J. Clark, Stephen C. Ekker, Jeffrey J. Essner, Wesley A. Wierson, Jordan M. Welker, Melanie E. Torrie, Drena Dobbs
Publikováno v:
Bio Protoc
Efficient precision genome engineering requires high frequency and specificity of integration at the genomic target site. Multiple design strategies for zebrafish gene targeting have previously been reported with widely varying frequencies for germli
Autor:
Stacy L. Solin, Dennis A. Webster, Zhitao Ming, Jacklyn Levey, Merrina Lan, Melanie E. Torrie, Beau R. Webber, Macy K. Vollbrecht, Jeffrey A. Haltom, Chi-Bin Chien, Drena Dobbs, Darius Balciunas, Wesley A. Wierson, Daniel F. Carlson, Kenna C. McKeighan, Sekhar Kambakam, Maira P. Almeida, Trevor J. Weiss, Branden S. Moriarity, Alec Wehmeier, Maura McGrail, Jordan M. Welker, Karl J. Clark, Christopher S. Mikelson, Kristen M. Kwan, Jeffrey J. Essner, Carla M. Mann, Stephen C. Ekker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e8b0227dd6445e73d5cd41308e5066d
https://doi.org/10.7554/elife.53968.sa2
https://doi.org/10.7554/elife.53968.sa2
Autor:
Jacklyn Levey, Merrina Lan, Carla M. Mann, Maura McGrail, Maira P. Almeida, Beau R. Webber, Kristen M. Kwan, Dennis A. Webster, Trevor J. Weiss, Jeffrey J. Essner, Darius Balciunas, Wesley A. Wierson, Karl J. Clark, Zhitao Ming, Jeffrey A. Haltom, Alec Wehmeier, Stephen C. Ekker, Melanie E. Torrie, Christopher S. Mikelson, Stacy L. Solin, Sekhar Kambakam, Daniel F. Carlson, Macy K. Vollbrecht, Branden S. Moriarity, Jordan M. Welker, Chi Bin Chien, Drena Dobbs, Kenna C. McKeighan
Publikováno v:
eLife, Cambridge : eLife Sciences Publications, Ltd, 2020, vol. 9, art. no. e53968, p. [1-25]
eLife, Vol 9 (2020)
eLife
eLife, Vol 9 (2020)
eLife
Efficient precision genome engineering requires high frequency and specificity of integration at the genomic target site. Here, we describe a set of resources to streamline reporter gene knock-ins in zebrafish and demonstrate the broader utility of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfdaa4c2ba4444b21a6e2fac41b3b74c
https://repository.vu.lt/VU:ELABAPDB141054958&prefLang=en_US
https://repository.vu.lt/VU:ELABAPDB141054958&prefLang=en_US
Autor:
Maura McGrail, Michael A. Barry, Bibekananda Kar, Zachary WareJoncas, Wesley A. Wierson, Stephen C. Ekker, Jeffrey J. Essner, William A.C. Gendron, Brandon W. Simone, Drena Dobbs, Jordan M. Welker, Carla M. Mann, Karl J. Clark
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR associated (Cas) effector proteins enable the targeting of DNA double-strand breaks (DSBs) to defined loci based on a variable length RNA guide specific to each effector. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6f19432026b2062ee41a7387863e5b
Autor:
Karl J. Clark, Maira P. Almeida, Gabriel Martínez-Gálvez, Drena Dobbs, Maura McGrail, Jordan M. Welker, Hirotaka Ata, Carla M. Mann, Stephen C. Ekker, Jeffrey J. Essner, Wesley A. Wierson
Publikováno v:
Nucleic Acids Research
The discovery and development of DNA-editing nucleases (Zinc Finger Nucleases, TALENs, CRISPR/Cas systems) has given scientists the ability to precisely engineer or edit genomes as never before. Several different platforms, protocols and vectors for
Autor:
Wesley A. Wierson, Jordan M. Welker, Maira P. Almeida, Carla M. Mann, Dennis A. Webster, Melanie E. Torrie, Trevor J. Weiss, Macy K. Vollbrecht, Merrina Lan, Kenna C. McKeighan, Jacklyn Levey, Zhitao Ming, Alec Wehmeier, Christopher S. Mikelson, Jeffrey A. Haltom, Kristen M. Kwan, Chi-Bin Chien, Darius Balciunas, Stephen C. Ekker, Karl J. Clark, Beau R. Webber, Branden Moriarity, Staci L. Solin, Daniel F. Carlson, Drena L. Dobbs, Maura McGrail, Jeffrey J. Essner
Choices for genome engineering and integration involve high efficiency with little or no target specificity or high specificity with low activity. Here, we describe a targeted integration strategy, called GeneWeld, and a vector series for gene taggin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd33a5971a72194470bd7f917dad8410