Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Carla M. Gauss"'
Autor:
Navasona Krishnan, Christopher A. Bonham, Ioana A. Rus, Om Kumar Shrestha, Carla M. Gauss, Aftabul Haque, Ante Tocilj, Leemor Joshua-Tor, Nicholas K. Tonks
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
The activity of protein tyrosine phosphatase PTP1B, a major metabolic regulator, depends on its oxidation state. Here the authors identify and characterize a small molecule that targets the oxidized, inactive form of PTP1B, suggesting a new therapeut
Externí odkaz:
https://doaj.org/article/ba9c741928c64ecab9592a1665278839
Autor:
John P. Wilson, Darryl J. Pappin, Jonathan J. Ipsaro, Keith Rivera, Katharine H. Dusenbury, Krisann Marquart, Nikita Saha Turna, Carla M. Gauss, Samantha N. Del Giudice
Publikováno v:
J Proteome Res
Bottom-up proteomics is a mainstay in protein identification and analysis. These studies typically employ proteolytic treatment of biological samples to generate suitably sized peptides for tandem mass spectrometric (MS) analysis. In MS, fragmentatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad33f53423abf67807b4b9f8027eba74
https://doi.org/10.1021/acs.jproteome.9b00713
https://doi.org/10.1021/acs.jproteome.9b00713
Autor:
Christopher A. Bonham, Nicholas K. Tonks, Leemor Joshua-Tor, Om Kumar Shrestha, Ioana A. Rus, Aftabul Haque, Ante Tocilj, Carla M. Gauss, Navasona Krishnan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature Communications
The protein tyrosine phosphatase PTP1B is a major regulator of glucose homeostasis and energy metabolism, and a validated target for therapeutic intervention in diabetes and obesity. Nevertheless, it is a challenging target for inhibitor development.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa31ecacee39a769842172de512aff52
https://doaj.org/article/ba9c741928c64ecab9592a1665278839
https://doaj.org/article/ba9c741928c64ecab9592a1665278839
Autor:
Akiyuki Hamasaki, Thomas J. Rayl, Dale L. Boger, Inkyu Hwang, Carla M. Gauss, Jay P. Parrish, Karen S. MacMillan
Efficient syntheses and a preliminary evaluation of 1,2,11,11a-tetrahydrocyclopropa[ c ]naphtho[2,3- e ]-indole (CNI) and 1,2,11,11a-tetrahydrocyclopropa[ c ]naphtho[1,2- e ]indole ( iso -CNI), and their derivatives containing an anthracene and phena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f335ea3902b0ed9f51c6076bac438f0
https://europepmc.org/articles/PMC2713043/
https://europepmc.org/articles/PMC2713043/
