Comprehensive clinicopathological and genomic profiling of gallbladder cancer reveals actionable targets in half of patients

Autor: Tessa J. J. de Bitter, Philip R. de Reuver, Elise A. J. de Savornin Lohman, Leonie I. Kroeze, Marianne E. Vink-Börger, Shannon van Vliet, Femke Simmer, Daniel von Rhein, Erik A. M. Jansen, Joanne Verheij, Carla M. L. van Herpen, Iris D. Nagtegaal, Marjolijn J. L. Ligtenberg, Rachel S. van der Post

Publikováno v: npj Precision Oncology, Vol 6, Iss 1, Pp 1-9 (2022)

Abstract Gallbladder cancer (GBC) is a rare, highly aggressive malignancy with a 5-year survival rate of 5–10% in advanced cases, highlighting the need for more effective therapies. The aim of this study was to identify potentially actionable thera

Externí odkaz: https://doaj.org/article/24ed2a0a62f547afb00d8943e706969e

Exposure–response analyses of cabozantinib in patients with metastatic renal cell cancer

Autor: Stefanie D. Krens, Nielka P. van Erp, Stefanie L. Groenland, Dirk Jan A. R. Moes, Sasja F. Mulder, Ingrid M. E. Desar, Tom van der Hulle, Neeltje Steeghs, Carla M. L. van Herpen

Publikováno v: BMC Cancer, Vol 22, Iss 1, Pp 1-12 (2022)

Abstract Aim In the registration trial, cabozantinib exposure ≥ 750 ng/mL correlated to improved tumor size reduction, response rate and progression free survival (PFS) in patients with metastatic renal cell cancer (mRCC). Because patients in routi

Externí odkaz: https://doaj.org/article/f27b5243be1f49888ffdb384331fa067

Differences in health care experiences between rare cancer and common cancer patients: results from a national cross-sectional survey

Autor: Eline de Heus, Vivian Engelen, Irene Dingemans, Carol Richel, Marga Schrieks, Jan Maarten van der Zwan, Marc G. Besselink, Mark I. van Berge Henegouwen, Carla M. L. van Herpen, Saskia F. A. Duijts

Publikováno v: Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-9 (2021)

Abstract Background Patients with rare cancers face challenges in the diagnostic and treatment phase, and in access to clinical expertise. Since studies on health care experiences of these patients in comparison to patients with more common cancers a

Externí odkaz: https://doaj.org/article/31e49316e68d42aea89ad37766e1d92a

Psychological aspects in patients with advanced cancer receiving lifelong systemic treatment: protocol for a scoping review

Autor: Linda Kwakkenbos, Winette T A van der Graaf, Evie E M Kolsteren, Esther Deuning-Smit, Judith B Prins, Carla M L van Herpen, Sophie Lebel, Belinda Thewes, José A E Custers

Publikováno v: BMJ Open, Vol 11, Iss 1 (2021)

Introduction A better understanding of the molecular, genetic and immunological characteristics of cancer and the introduction of new systemic treatment regimens in the last decades, has led to better treatment outcomes and increased survival rates f

Externí odkaz: https://doaj.org/article/c2d24b5dbdbc42788d1746f2f0cabe0b

Lean Body Mass and Total Body Weight Versus Body Surface Area as a Determinant of Docetaxel Pharmacokinetics and Toxicity

Autor: Rien H. L. Hoge, Suzan E. H. Detert Oude Weme, Walter L. Vervenne, Inge R. F. van Berlo-van de Laar, Carla M. L. van Herpen, Laurens Roorda, Ron A. A. Mathôt, Maartje S. Jacobs, Nielka P. van Erp, Frank G. A. Jansman

Publikováno v: Therapeutic Drug Monitoring, 44, 755-761
Therapeutic Drug Monitoring, 44, 6, pp. 755-761
Therapeutic drug monitoring, 44(6), 755-761. Lippincott Williams and Wilkins
Therapeutic Drug Monitoring, 44(6), 755-761. LIPPINCOTT WILLIAMS & WILKINS

AIM: This study examined whether anthropometric and body composition parameters such as body surface area (BSA), lean body mass (LBM), and total body weight (TBW) are correlated with docetaxel clearance and exposure by analyzing area under the curve.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e80c2337da9e2e4488006c64838550
https://doi.org/10.1097/ftd.0000000000001029