Tailored Cytokine Optimization for ex vivo Culture Platforms Targeting the Expansion of Human Hematopoietic Stem/Progenitor Cells

Autor: André Branco, Sara Bucar, Jorge Moura-Sampaio, Carla Lilaia, Joaquim M. S. Cabral, Ana Fernandes-Platzgummer, Cláudia Lobato da Silva

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)

Umbilical cord blood (UCB) has been established as an alternative source for hematopoietic stem/progenitor cells (HSPC) for cell and gene therapies. Limited cell yields of UCB units have been tackled with the development of cytokine-based ex vivo exp

Externí odkaz: https://doaj.org/article/02008d7f45cf42b596466fdbc03d3776

Integrated culture platform based on a human platelet lysate supplement for the isolation and scalable manufacturing of umbilical cord matrix-derived mesenchymal stem/stromal cells

Autor: Shi-Hwei Liu, Francisco Moreira, Cláudia Lobato da Silva, Chen-Peng Ku, Ana Fernandes-Platzgummer, Joaquim M. S. Cabral, William Milligan, António M. de Soure, Carla Lilaia, Yi-Feng Huang

Publikováno v: Journal of Tissue Engineering and Regenerative Medicine. 11:1630-1640

Umbilical cord matrix (UCM)-derived mesenchymal stem/stromal cells (MSCs) are promising therapeutic candidates for regenerative medicine settings. UCM MSCs have advantages over adult cells as these can be obtained through a non-invasive harvesting pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ac43a0dad2ea73ce2447d105640cb8d
https://doi.org/10.1002/term.2200

Developing a co-culture system for effective megakaryo/thrombopoiesis from umbilical cord blood hematopoietic stem/progenitor cells

Autor: Cláudia Lobato da Silva, A. P. Alves de Matos, Dusan Djokovic, Frederico Castelo Ferreira, Joaquim M. S. Cabral, Javad Hatami, Pedro Z. Andrade, Carla Lilaia

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ResearcherID

Background aims. Platelet transfusion can be a life-saving procedure in different medical settings. Thus, there is an increasing demand for platelets, of which shelf-life is only 5 days. The efficient ex vivo biomanufacturing of platelets would allow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7225629b6d4fb8ad66ee656ac5bcd9c