Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Carla L. Esposito"'
Autor:
Maria L. Ibba, Giuseppe Ciccone, Deborah Rotoli, Gabriele Coppola, Alfonso Fiorelli, Silvia Catuogno, Carla L. Esposito
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 111-126 (2023)
The identification of new effective therapeutic options for non-small-cell lung cancer (NSCLC) represents a crucial challenge in oncology. Recent studies indicate that cancer-associated fibroblasts (CAFs) participate in tumor progression by establish
Externí odkaz:
https://doaj.org/article/355f7b2b64c748fa9e32d04320a16a88
Autor:
Carla L. Esposito, Ida Autiero, Annamaria Sandomenico, H. Li, Mahmoud A. Bassal, Maria L. Ibba, Dongfang Wang, Lucrezia Rinaldi, Simone Ummarino, Giulia Gaggi, Marta Borchiellini, Piotr Swiderski, Menotti Ruvo, Silvia Catuogno, Alexander K. Ebralidze, Marcin Kortylewski, Vittorio de Franciscis, Annalisa Di Ruscio
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Here the authors generate an RNA-based platform to neutralize the major epigenetic player DNMT1. Using this targeted approach, aberrant DNA methylation in cancer can be corrected.
Externí odkaz:
https://doaj.org/article/1ac7b00822ad42efaffe5d498c64c726
Autor:
Carla L. Esposito, Katrien Van Roosbroeck, Gianluca Santamaria, Deborah Rotoli, Annamaria Sandomenico, William G. Wierda, Alessandra Ferrajoli, Menotti Ruvo, George A. Calin, Vittorio de Franciscis, Silvia Catuogno
Publikováno v:
Cancers, Vol 13, Iss 20, p 5220 (2021)
The transmembrane glycoprotein cluster of differentiation 19 (CD19) is a B cell–specific surface marker, expressed on the majority of neoplastic B cells, and has recently emerged as a very attractive biomarker and therapeutic target for B-cell mali
Externí odkaz:
https://doaj.org/article/bec828a0b55e41e0a65683a2c208977a
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 17, p 6075 (2020)
Non-small-cell lung cancer (NSCLC) is the most common type of lung cancer worldwide, with the highest incidence in developed countries. NSCLC patients often face resistance to currently available therapies, accounting for frequent relapses and poor p
Externí odkaz:
https://doaj.org/article/6ecf5700b0df401788b81f9d5f279d41
Publikováno v:
Cancers, Vol 12, Iss 6, p 1365 (2020)
Tumor mass consists of a complex ensemble of malignant cancer cells and a wide variety of resident and infiltrating cells, secreted factors, and extracellular matrix proteins that are referred as tumor microenvironment (TME). Cancer associated fibrob
Externí odkaz:
https://doaj.org/article/75fbc9a0e9294730a420390131cc30e2
Autor:
Vittorio de Franciscis, Laura Cerchia, Gerolama Condorelli, Silvia Catuogno, Cristina Quintavalle, Carla L. Esposito
Publikováno v:
Cancers, Vol 3, Iss 2, Pp 1877-1898 (2011)
MicroRNAs (miRNAs) are short non-protein-coding RNA molecules that regulate the expression of a wide variety of genes. They act by sequence-specific base pairing in the 3’ untranslated region (3’UTR) of the target mRNA leading to mRNA degradation
Externí odkaz:
https://doaj.org/article/3ac2b8122e784b96aa5f9df00260be87
Publikováno v:
Pharmaceuticals, Vol 9, Iss 4, p 69 (2016)
The selective delivery of drugs in a cell- or tissue-specific manner represents the main challenge for medical research; in order to reduce the occurrence of unwanted off-target effects. In this regard, nucleic acid aptamers have emerged as an attrac
Externí odkaz:
https://doaj.org/article/82ce1bc9ef3c429ab5bb1748340c443a
Autor:
Carla L. Esposito, Ida Autiero, Annamaria Sandomenico, H. Li, Mahmoud A. Bassal, Maria L. Ibba, Dongfang Wang, Lucrezia Rinaldi, Simone Ummarino, Giulia Gaggi, Marta Borchiellini, Piotr Swiderski, Menotti Ruvo, Silvia Catuogno, Alexander K. Ebralidze, Marcin Kortylewski, Vittorio de Franciscis, Annalisa Di Ruscio
Publikováno v:
Nature communications. 14(1)
DNA methylation is a fundamental epigenetic modification regulating gene expression. Aberrant DNA methylation is the most common molecular lesion in cancer cells. However, medical intervention has been limited to the use of broadly acting, small mole
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1364
microRNAs (miRNAs) are short noncoding RNAs that effectively regulate the expression of a wide variety of genes. Increasing evidences have shown a fundamental role of miRNAs in cancer initiation and progression, thus indicating these molecules among
Autor:
Vittorio de Franciscis, Carla Lucia Esposito, Gianluca Santamaria, Gennaro De Vita, Silvia Catuogno, Laura Cerchia, Gerolama Condorelli, Paloma H. Giangrande, Piotr Swiderski, Justin P. Dassie
Publikováno v:
Molecular Therapy. 22:1151-1163
While microRNAs (miRNAs) clearly regulate multiple pathways integral to disease development and progression, the lack of safe and reliable means for specific delivery of miRNAs to target tissues represents a major obstacle to their broad therapeutic