Different Transcriptomic Response to T. cruzi Infection in hiPSC-Derived Cardiomyocytes From Chagas Disease Patients With and Without Chronic Cardiomyopathy

Autor: Theo G. M. Oliveira, Gabriela Venturini, Juliana M. Alvim, Larissa L. Feijó, Carla L. Dinardo, Ester C. Sabino, Jonathan G. Seidman, Christine E. Seidman, Jose E. Krieger, Alexandre C. Pereira

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

Chagas disease is a tropical zoonosis caused by Trypanosoma cruzi. After infection, the host present an acute phase, usually asymptomatic, in which an extensive parasite proliferation and intense innate immune activity occurs, followed by a chronic p

Externí odkaz: https://doaj.org/article/7359d2ff660a4e718bab58592d9d3da5

How Ancestry Influences the Chances of Finding Unrelated Donors: An Investigation in Admixed Brazilians

Autor: Kelly Nunes, Vitor R. C. Aguiar, Márcio Silva, Alexandre C. Sena, Danielli C. M. de Oliveira, Carla L. Dinardo, Fernanda S. G. Kehdy, Eduardo Tarazona-Santos, Vanderson G. Rocha, Anna Barbara F. Carneiro-Proietti, Paula Loureiro, Miriam V. Flor-Park, Claudia Maximo, Shannon Kelly, Brian Custer, Bruce S. Weir, Ester C. Sabino, Luís Cristóvão Porto, Diogo Meyer

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

A match of HLA loci between patients and donors is critical for successful hematopoietic stem cell transplantation. However, the extreme polymorphism of HLA loci – an outcome of millions of years of natural selection – reduces the chances that tw

Externí odkaz: https://doaj.org/article/7135c23b854d4ea48891ccb520ebe641

Rare genetic variants explain missing heritability in smoking

Autor: Seon-Kyeong Jang, Luke Evans, Allison Fialkowski, Donna K. Arnett, Allison E. Ashley-Koch, Kathleen C. Barnes, Diane M. Becker, Joshua C. Bis, John Blangero, Eugene R. Bleecker, Meher Preethi Boorgula, Donald W. Bowden, Jennifer A. Brody, Brian E. Cade, Brenda W. Campbell Jenkins, April P. Carson, Sameer Chavan, L. Adrienne Cupples, Brian Custer, Scott M. Damrauer, Sean P. David, Mariza de Andrade, Carla L. Dinardo, Tasha E. Fingerlin, Myriam Fornage, Barry I. Freedman, Melanie E. Garrett, Sina A. Gharib, David C. Glahn, Jeffrey Haessler, Susan R. Heckbert, John E. Hokanson, Lifang Hou, Shih-Jen Hwang, Matthew C. Hyman, Renae Judy, Anne E. Justice, Robert C. Kaplan, Sharon L. R. Kardia, Shannon Kelly, Wonji Kim, Charles Kooperberg, Daniel Levy, Donald M. Lloyd-Jones, Ruth J. F. Loos, Ani W. Manichaikul, Mark T. Gladwin, Lisa Warsinger Martin, Mehdi Nouraie, Olle Melander, Deborah A. Meyers, Courtney G. Montgomery, Kari E. North, Elizabeth C. Oelsner, Nicholette D. Palmer, Marinelle Payton, Anna L. Peljto, Patricia A. Peyser, Michael Preuss, Bruce M. Psaty, Dandi Qiao, Daniel J. Rader, Nicholas Rafaels, Susan Redline, Robert M. Reed, Alexander P. Reiner, Stephen S. Rich, Jerome I. Rotter, David A. Schwartz, Aladdin H. Shadyab, Edwin K. Silverman, Nicholas L. Smith, J. Gustav Smith, Albert V. Smith, Jennifer A. Smith, Weihong Tang, Kent D. Taylor, Marilyn J. Telen, Ramachandran S. Vasan, Victor R. Gordeuk, Zhe Wang, Kerri L. Wiggins, Lisa R. Yanek, Ivana V. Yang, Kendra A. Young, Kristin L. Young, Yingze Zhang, Dajiang J. Liu, Matthew C. Keller, Scott Vrieze

Publikováno v: Nature human behaviour, vol 6, iss 11
Nat Hum Behav

Common genetic variants explain less variation in complex phenotypes than inferred from family-based studies, and there is a debate on the source of this 'missing heritability'. We investigated the contribution of rare genetic variants to tobacco use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30aa88d7690dcca16453c7af4c2f580f
https://escholarship.org/uc/item/3v26257d

Clonal hematopoiesis in sickle cell disease

Autor: L. Alexander Liggett, Liam D. Cato, Joshua S. Weinstock, Yingze Zhang, S. Mehdi Nouraie, Mark T. Gladwin, Melanie E. Garrett, Allison Ashley-Koch, Marilyn J. Telen, Brian Custer, Shannon Kelly, Carla L. Dinardo, Ester C. Sabino, Paula Loureiro, Anna B. Carneiro-Proietti, Cláudia Maximo, Alexander P. Reiner, Gonçalo R. Abecasis, David A. Williams, Pradeep Natarajan, Alexander G. Bick, Vijay G. Sankaran

Publikováno v: The Journal of clinical investigation. 132(4)

BACKGROUNDCurative gene therapies for sickle cell disease (SCD) are currently undergoing clinical evaluation. The occurrence of myeloid malignancies in these trials has prompted safety concerns. Individuals with SCD are predisposed to myeloid maligna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950cc7a204b890b48717937cdb50e5d7
https://pubmed.ncbi.nlm.nih.gov/35175224

High-throughput strategy for molecular identification of Vel- blood donors employing nucleic acids extracted from plasma pools used for viral nucleic acid test screening

Autor: Marcia R, Dezan, Carla L, Dinardo, Silvia R A, Bosi, Sileni, Vega, Nanci A, Salles, Alfredo, Mendrone-Júnior, José E, Levi

Publikováno v: Transfusion. 56(6)

Serologic methods to determine the Vel- phenotype require the use of rare human antisera and do not allow for many samples to be tested simultaneously, which limits their application as a tool to search for rare donors. This study developed a low-cos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d04a3888996411ad0c4af8b9d17fda29
https://pubmed.ncbi.nlm.nih.gov/27060345