Gut microbiome and plasma lipidome analysis reveals a specific impact of Clostridioides difficile infection on intestinal bacterial communities and sterol metabolism

Autor: Ricardo Arcay, Maria Barceló-Nicolau, Loreto Suárez, Luisa Martín, Rebeca Reigada, Marcus Höring, Gerhard Liebisch, Carmen Garrido, Gabriel Cabot, Helem Vílchez, Sara Cortés-Lara, Elisa González de Herrero, Carla López-Causapé, Antonio Oliver, Gwendolyn Barceló-Coblijn, Ana Mena

Publikováno v: mBio, Vol 15, Iss 10 (2024)

ABSTRACT Clostridioides difficile infection (CDI) causes alterations in the intestinal microbiota, frequently associated with changes in the gut metabolism of bile acids and cholesterol. In addition to the impact on microbiome composition and given t

Externí odkaz: https://doaj.org/article/d6710211fc094a21aeacb8c91a2ef436

A multicomponent smoking cessation program for adults with Type 2 Diabetes Mellitus (DiMe-SALUD2 project): A study protocol of a randomized controlled trial

Autor: Carla López-Núñez, Sergio Fernández-Artamendi, Desirée Ruiz-Aranda, Davinia María Resurrección, Desirée Navas-Campaña

Publikováno v: Contemporary Clinical Trials Communications, Vol 41, Iss , Pp 101361- (2024)

Background: Tobacco use represents a significant public health burden, being especially harmful for smokers with Type 2 Diabetes Mellitus (T2DM). Effective smoking cessation interventions are required for this vulnerable population. The goal is to de

Externí odkaz: https://doaj.org/article/a9f916ee2d0a44e58c8a588a6a521a38

Mixed strain pathogen populations accelerate the evolution of antibiotic resistance in patients

Autor: Julio Diaz Caballero, Rachel M. Wheatley, Natalia Kapel, Carla López-Causapé, Thomas Van der Schalk, Angus Quinn, Liam P. Shaw, Lois Ogunlana, Claudia Recanatini, Basil Britto Xavier, Leen Timbermont, Jan Kluytmans, Alexey Ruzin, Mark Esser, Surbhi Malhotra-Kumar, Antonio Oliver, R. Craig MacLean

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)

Abstract Antibiotic resistance poses a global health threat, but the within-host drivers of resistance remain poorly understood. Pathogen populations are often assumed to be clonal within hosts, and resistance is thought to emerge due to selection fo

Externí odkaz: https://doaj.org/article/c8f2767653e74ecc9aa65a300ff1615f

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Pseudomonas aeruginosa antibiotic susceptibility profiles, genomic epidemiology and resistance mechanisms: a nation-wide five-year time lapse analysisResearch in context

Autor: Miquel Àngel Sastre-Femenia, Almudena Fernández-Muñoz, María Antonia Gomis-Font, Biel Taltavull, Carla López-Causapé, Jorge Arca-Suárez, Luis Martínez-Martínez, Rafael Cantón, Nieves Larrosa, Jesús Oteo-Iglesias, Laura Zamorano, Antonio Oliver, Fátima Galán-Sánchez, Irene Gracia-Ahufinger, Carmen Liébana-Martos, Carolina Roldán, Juan Manuel Sánchez-Calvo, Encarnación Clavijo, Laura Mora-Navas, Javier Aznar, José Antonio Lepe, Ángel Rodríguez-Villodres, Esther Recacha, Francisco Javier Casas-Círia, Carmen Martínez-Rubio, Marco Antonio Sempere-Alcocer, Lina Martín-Hita, Cristina Seral, Ana Isabel López-Calleja, Carmen Aspiroz, Marisa Monforte, Pedro de la Iglesia-Martínez, Gemma Jimenez-Guerra, Elena Riera-Pérez, Carmen Collado, Carmen Gallegos, Xavier Mulet, Miquel Àngel Sastre-Femenía, María Siller-Ruiz, Jorge Calvo, Dolores Quesada, Jun Hao Wang, Cristina Pitart, Francesc Marco, Nuria Prim, Juan Pablo Horcajada, Eduardo Padilla, Ester Del Barrio-Tofiño, Belen Viñado-Pérez, Fe Tubau, Silvia Capilla, Antonio Casabella, Mar Olga Pérez-Moreno, Emma Padilla, Mónica Ballestero, Alba Rivera, Ferrán Navarro, Fréderic Gómez-Bertomeu, Sergio Pardo-Granell, Ester Picó-Plana, Dolores Guerrero, Carolina Sarvisé-Buil, Alba Belles-Belles, Marta Fernández-Esgueva, María del Pilar Ortega-Lafont, Inmaculada García, Noelia Arenal-Andrés, Susana Hernando-Real, Rosario Ibáñez, Jesús Martínez, Federico Becerra, Carmen Aldea-Mansilla, Asmaa Alaoui-Sosse, José Carlos González, Julia Guzman-Puche, Miguel Ángel Blázquez-Andrada, Nora Mariela Martínez-Ramírez, Alicia Beteta, Bárbara Gomila-Sard, Salvador Giner Almaraz, Eugenio Garduño, Pedro Miguel Juiz-González, Javier Alba, Pilar Alonso, Ana Isabel Rodríguez, María Isabel Paz-Vidal, Marta García-Campello, Pablo Camacho, María de los Ángeles Pallarés, María Luisa Pérez del Molino, Amparo Coira, Gema Barbeito, Anniris Rincón, Francisco José Vasallo-Vidal, Laura Alonso-Acero, Laura Iglesias-Llorente, Ana Bordes-Benites, Laura Florén-Zabala, José Manuel Azcona, Carla Andrea Alonso, Yolanda Sáenz, Marta Lamata-Subero, David Molina, Ana González-Torralba, Jennifer Villa, Esther Viedma, Emilia Cercenado, Teresa Alarcón, Paula Vargas, María Díez, Patricia Ruiz, María Isabel Sánchez-Romero, Felipe Pérez-García, Genoveva Yagüe-Guirao, Amaia Concepción Oteiza, José Leiva, María Eugenia Portillo, Andrés Canut-Blasco, Matxalen Vidal, Iker Alonso, Maider Zuriarrain, José Luis Barrios-Andrés

Publikováno v: The Lancet Regional Health. Europe, Vol 34, Iss , Pp 100736- (2023)

Summary: Background: Pseudomonas aeruginosa healthcare-associated infections are one of the top antimicrobial resistance threats world-wide. In order to analyze the current trends, we performed a Spanish nation-wide high-resolution analysis of the su

Externí odkaz: https://doaj.org/article/161127b61b5a40a5a115c9865b9c16f8