Výsledky vyhledávání - "Carla Jhoana Ramos"

The EPAC–Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability

Autor: Cheng-mao Lin, David A. Antonetti, Carla Jhoana Ramos, Xuwen Liu

Publikováno v: Journal of Biological Chemistry. 293:717-730

Increased retinal vascular permeability contributes to macular edema, a leading cause of vision loss in eye pathologies such as diabetic retinopathy, age-related macular degeneration, and central retinal vein occlusions. Pathological changes in vascu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24fb4f5d3c2a21c7d7f6331ad760ec9e
https://doi.org/10.1074/jbc.m117.815381

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The Peroxisome Proliferator-Activated Receptor-β/δ antagonist GSK0660 mitigates Retinal Cell Inflammation and Leukostasis

Autor: Gary W. McCollum, Sara R. Savage, Carla Jhoana Ramos, Sandra S. Hammer, John S. Penn, Rong Yang, Megan E. Capozzi, Colin A. Bretz

Publikováno v: Exp Eye Res

Diabetic retinopathy (DR) is triggered by retinal cell damage stimulated by the diabetic milieu, including increased levels of intraocular free fatty acids. Free fatty acids may serve as an initiator of inflammatory cytokine release from Muller cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1453827888607118f028529734b99721
https://europepmc.org/articles/PMC7426872/

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The inner Blood-Retinal Barrier: Cellular Basis and Development

Autor: David A. Antonetti, Carla Jhoana Ramos, Mónica Díaz-Coránguez

The blood-retinal barrier (BRB) regulates transport across retinal capillaries maintaining proper neural homeostasis and protecting the neural tissue from potential blood borne toxicity. Loss of the BRB contributes to the pathophysiology of a number

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d614581406cc5720d5a44da7e60dba
https://europepmc.org/articles/PMC5723228/

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The role of small GTPases and EPAC-Rap signaling in the regulation of the blood-brain and blood-retinal barriers

Autor: David A. Antonetti, Carla Jhoana Ramos

Publikováno v: Tissue Barriers. 5:e1339768

Maintenance and regulation of the vascular endothelial cell junctional complex is critical for proper barrier function of the blood-brain barrier (BBB) and the highly related blood-retinal barrier (BRB) that help maintain proper neuronal environment.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2dd458075f2e698a0e630e92c9ed1b6
https://doi.org/10.1080/21688370.2017.1339768

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