Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Carla J. Shatz"'
Autor:
TD Barbara Nguyen-Vu, Grace Q Zhao, Subhaneil Lahiri, Rhea R Kimpo, Hanmi Lee, Surya Ganguli, Carla J Shatz, Jennifer L Raymond
Publikováno v:
eLife, Vol 6 (2017)
Across many studies, animals with enhanced synaptic plasticity exhibit either enhanced or impaired learning, raising a conceptual puzzle: how enhanced plasticity can yield opposite learning outcomes? Here, we show that the recent history of experienc
Externí odkaz:
https://doaj.org/article/0e2fd4986302466e8fec0a76349b0c39
Autor:
Ioana A. Marin, Alan Y. Gutman-Wei, Kylie S. Chew, Aram J. Raissi, Maja Djurisic, Carla J. Shatz
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(23)
During developmental critical periods, circuits are sculpted by a process of activity-dependent competition. The molecular machinery involved in regulating the complex process of responding to different levels of activity is now beginning to be ident
SUMMARYDendritic spine dynamics of Layer 5 Pyramidal neurons (L5PNs) are thought to be physical substrates for motor learning and memory of motor skills and altered spine dynamics are frequently correlated with poor motor performance. Here we describ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48bc582081c522b42a79ac84fa15c9e6
https://doi.org/10.1101/2021.01.27.428554
https://doi.org/10.1101/2021.01.27.428554
Publikováno v:
Molecular psychiatry
The threshold for Hebbian synaptic plasticity in the CNS is modulated by prior synaptic activity. At adult CA3-CA1 synapses, endocannabinoids play a role in this process, but how activity engages and maintains this retrograde signaling system is not
Publikováno v:
Neuron
Dendritic spine dynamics are thought to be substrates for motor learning and memory, and altered spine dynamics often lead to impaired performance. Here, we describe an exception to this rule by studying mice lacking paired immunoglobulin receptor B
Publikováno v:
PLoS Biology, Vol 5, Iss 3, p e61 (2007)
Patterned spontaneous activity in the developing retina is necessary to drive synaptic refinement in the lateral geniculate nucleus (LGN). Using perforated patch recordings from neurons in LGN slices during the period of eye segregation, we examine h
Externí odkaz:
https://doaj.org/article/428e7c9693054480ba06ac58703b5c19
Background Dendritic spines are structural correlates of excitatory synapses in the brain. Their density and structure are shaped by experience, pointing to their role in memory encoding. Dendritic spine imaging, followed by manual analysis, is a pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e441e2a1fb26e4a21b67f1c2778de3
https://europepmc.org/articles/PMC6402488/
https://europepmc.org/articles/PMC6402488/
Autor:
Carla J. Shatz
Publikováno v:
Pattern Formation in the Physical and Biological Sciences ISBN: 9780429493362
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd3a2842da1ee11cd9136ab5efa222e3
https://doi.org/10.1201/9780429493362-13
https://doi.org/10.1201/9780429493362-13
Autor:
Surya Ganguli, Hanmi Lee, Carla J. Shatz, Jennifer L. Raymond, Subhaneil Lahiri, TD Barbara Nguyen-Vu, Grace Zhao, Rhea R. Kimpo
Publikováno v:
eLife, Vol 6 (2017)
eLife
eLife
Across many studies, animals with enhanced synaptic plasticity exhibit either enhanced or impaired learning, raising a conceptual puzzle: how enhanced plasticity can yield opposite learning outcomes? Here, we show that the recent history of experienc
Autor:
Akash Datwani, Carla J. Shatz, Marla B. Feller, Barbara K. Brott, Lowry A. Kirkby, Hanmi Lee, Sarah Cheng, Jaimie D. Adelson
Publikováno v:
Nature
Nature, vol 509, iss 7499
Nature, vol 509, iss 7499
The formation of precise connections between retina and lateral geniculate nucleus (LGN) involves the activity-dependent elimination of some synapses, with strengthening and retention of others. Here we show that the major histocompatibility complex