Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Carla J, Aldrich"'
Autor:
Ronald C. Wek, Judy K. Cundiff, Rachel B. Reinert, Carla J. Aldrich, Tracy G. Anthony, Piyawan Bunpo
Publikováno v:
The Journal of Nutrition. 140:2020-2027
Amino acid starvation by asparaginase (ASNase) enhances phosphorylation of eukaryotic initiation factor 2 (eIF2) by general control nonderepressible 2 (GCN2) kinase, leading to reduced global mRNA translation rates. This conserves energy and allows c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0195ea96828956641169159212687f9a
https://doi.org/10.3945/jn.110.129197
https://doi.org/10.3945/jn.110.129197
Autor:
Carla J. Aldrich, Betty S Murray, Emma Brizius, Tracy G. Anthony, Piyawan Bunpo, Judy K. Cundiff
Publikováno v:
The Journal of Nutrition. 138:338-343
Asparaginase (Elspar) is used in the treatment of acute lymphoblastic leukemia. It depletes plasma asparagine and glutamine, killing leukemic lymphoblasts but also causing immunosuppression. The objective of this work was to assess whether supplement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f06736f159c8e13b31d8679859c48f34
https://doi.org/10.1093/jn/138.2.338
https://doi.org/10.1093/jn/138.2.338
Role of Glutamine Depletion in Directing Tissue-specific Nutrient Stress Responses to L-Asparaginase
Autor:
Rachel B. Reinert, Margaret A. McNurlan, Donald L. Durden, Tracy G. Anthony, Izolda Mileva, Xue Ping Wang, Piyawan Bunpo, Leslie O. Goodwin, Sheree A. Wek, Ronald C. Wek, Carla J. Aldrich, L. Morgan Oberle
Publikováno v:
Journal of Biological Chemistry. 281:31222-31233
l-Asparaginase is important in the induction regimen for treating acute lymphoblastic leukemia. Cytotoxic complications are clinically significant problems lacking mechanistic insight. To reveal tissue-specific molecular responses to this drug, mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79e52a9f7b225445af475e868cb7fad
https://doi.org/10.1016/s0021-9258(19)84035-8
https://doi.org/10.1016/s0021-9258(19)84035-8
Autor:
Suzanne R. Kalb, Bitao Liang, Carla J. Aldrich, Mark J. Soloski, François A. Lemonnier, Adrian Davies, Hong Jiang, Robert J. Cotter
Publikováno v:
The Journal of Immunology. 170:5027-5033
The MHC class Ib molecule Qa-1 binds specifically and predominantly to a single 9-aa peptide (AMAPRTLLL) derived from the leader sequence of many MHC class Ia proteins. This peptide is referred to as Qdm. In this study, we report the isolation and se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e9b0ea23639919733a20947d54196e8
https://doi.org/10.4049/jimmunol.170.10.5027
https://doi.org/10.4049/jimmunol.170.10.5027
Autor:
H. R. Gaskins, Taehoon Chun, Mark J. Soloski, Carla J. Aldrich, L. V. Kawczynski, Manuel E. Baldeón
Publikováno v:
Immunology. 94:64-71
Enhanced major histocompatibility complex (MHC) class I expression is a prominent early feature of pancreatic beta-cell pathology in autoimmune diabetes. The number and nature of class I MHC loci expressed by beta cells are generally undefined and po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fbed2097ee7d4928ff8b1f798b8fa12
https://doi.org/10.1046/j.1365-2567.1998.00475.x
https://doi.org/10.1046/j.1365-2567.1998.00475.x
Publikováno v:
JAK-STAT
The generation of germline gene mutations in mice has been an invaluable tool for experimental biology. However, studying immune responses that develop in the absence of a specific protein that could alter thymic selection complicates experimental in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5413f3aded1da3e01049ae7c38add2a
https://pubmed.ncbi.nlm.nih.gov/24058815
https://pubmed.ncbi.nlm.nih.gov/24058815
Publikováno v:
Immunological Reviews. 147:67-89
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::906c097987b490b7f1fc3f4efea41999
https://doi.org/10.1111/j.1600-065x.1995.tb00088.x
https://doi.org/10.1111/j.1600-065x.1995.tb00088.x
Autor:
J. Forman, L Van Kaer, Hans-Gustaf Ljunggren, Carla J. Aldrich, P. G. Ashton-Rickardt, Susumu Tonegawa
Publikováno v:
Proceedings of the National Academy of Sciences. 91:6525-6528
Mice with a homozygous deletion in their Tap-1 gene (-/- mice) express very low levels of cell membrane major histocompatibility complex class I molecules and have < 1% peripheral CD8+ T cells. We show that these -/- mice but not their +/- littermate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc64f46e67194396231dbe3efce6423f
https://doi.org/10.1073/pnas.91.14.6525
https://doi.org/10.1073/pnas.91.14.6525
Autor:
Yik Yeung Lawrence Yu, Lorraine Flaherty, James Forman, Carla J. Aldrich, Vinay Kumar, Michael J. Bennett, Bruce R. Blazar
Publikováno v:
International Immunology. 6:1297-1306
Murine natural killer (NK) cells can mediate specific rejection of bone marrow cell (BMC) allografts. Whereas positive recognition of allogeneic MHC antigens forms the basis for T cell alloreactivity, it has been postulated that NK cells are reactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458b491add5b072ca2cd44de5f074b3b
https://doi.org/10.1093/intimm/6.9.1297
https://doi.org/10.1093/intimm/6.9.1297
Autor:
Piyawan, Bunpo, Betty, Murray, Judy, Cundiff, Emma, Brizius, Carla J, Aldrich, Tracy G, Anthony
Publikováno v:
The Journal of nutrition. 138(2)
Asparaginase (Elspar) is used in the treatment of acute lymphoblastic leukemia. It depletes plasma asparagine and glutamine, killing leukemic lymphoblasts but also causing immunosuppression. The objective of this work was to assess whether supplement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7efa223ae2d8bb8f9cede27b1bb6743a
https://pubmed.ncbi.nlm.nih.gov/18203901
https://pubmed.ncbi.nlm.nih.gov/18203901