Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Carla Garcia‐Cabau"'
Autor:
Pablo Lujan, Carla Garcia-Cabau, Yuichi Wakana, Javier Vera Lillo, Carmen Rodilla-Ramírez, Hideaki Sugiura, Vivek Malhotra, Xavier Salvatella, Maria F Garcia-Parajo, Felix Campelo
Publikováno v:
eLife, Vol 12 (2024)
Secretory proteins are sorted at the trans-Golgi network (TGN) for export into specific transport carriers. However, the molecular players involved in this fundamental process remain largely elusive. Here, we identified the human transmembrane protei
Externí odkaz:
https://doaj.org/article/6941725be9904fe88ea7ca8d85a07ae9
Autor:
Daniel Natera‐de Benito, Jonathan Olival, Carla Garcia‐Cabau, Cristina Jou, Mònica Roldan, Anna Codina, Jessica Expósito‐Escudero, Cristina Batlle, Laura Carrera‐García, Carlos Ortez, Xavier Salvatella, Francesc Palau, Andrés Nascimento, Janet Hoenicka
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 3, Pp 408-425 (2023)
Abstract Objective Mutations in ANXA11 cause amyotrophic lateral sclerosis (ALS) and have recently been identified as a cause of multisystem proteinopathy and adult‐onset muscular dystrophy. These conditions are adult‐onset diseases and result fr
Externí odkaz:
https://doaj.org/article/078decfbead04403a37de8b0a43ecdd4
Autor:
Albert Escobedo, Jonathan Piccirillo, Juan Aranda, Tammo Diercks, Borja Mateos, Carla Garcia-Cabau, Macarena Sánchez-Navarro, Busra Topal, Mateusz Biesaga, Lasse Staby, Birthe B. Kragelund, Jesús García, Oscar Millet, Modesto Orozco, Murray Coles, Ramon Crehuet, Xavier Salvatella
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Targeting biomedically relevant protein-protein interactions is a long-lasting challenge in medicinal chemistry. Here, the authors develop a single α-helical peptide scaffold that can be tailored to target globular proteins of biomedical interest.
Externí odkaz:
https://doaj.org/article/0ea4c921c75c4f04849c5efbc9071b23
Autor:
Marie Christou-Kent, Sergi Cuartero, Carla Garcia-Cabau, Julia Ruehle, Julian Naderi, Julia Erber, Maria Victoria Neguembor, Marcos Plana-Carmona, Marc Alcoverro-Bertran, Luisa De Andres-Aguayo, Antonios Klonizakis, Eric Julià-Vilella, Cian Lynch, Manuel Serrano, Denes Hnisz, Xavier Salvatella, Thomas Graf, Grégoire Stik
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112897- (2023)
Summary: Cell identity is orchestrated through an interplay between transcription factor (TF) action and genome architecture. The mechanisms used by TFs to shape three-dimensional (3D) genome organization remain incompletely understood. Here we prese
Externí odkaz:
https://doaj.org/article/f919872c3ea44338bf8df8ef1c78878a
Autor:
Carla Garcia-Cabau, Anna Bartomeu, Andreea Balaceanu, Giulio Tesei, Berta Duran-Arqué, Marcos Fernández-Alfara, Judit Martín, Cesare De Pace, Lorena Ruiz-Pérez, Jesús García, Giuseppe Battaglia, Kresten Lindorff-Larsen, Raúl Méndez, Xavier Salvatella
The inclusion of microexons by alternative splicing is frequent in neuronal proteins. The roles of these sequences are in most cases unknown, but changes in their degree of inclusion are associated with neurodevelopmental diseases. We recently found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69ba28594999e3a4cdd1cee26444a455
https://doi.org/10.1101/2023.03.19.532587
https://doi.org/10.1101/2023.03.19.532587
Autor:
Martin A. Mensah, Henri Niskanen, Alexandre P. Magalhaes, Shaon Basu, Martin Kircher, Henrike L. Sczakiel, Alisa M. V. Reiter, Jonas Elsner, Peter Meinecke, Saskia Biskup, Brian H. Y. Chung, Gregor Dombrowsky, Christel Eckmann-Scholz, Marc Phillip Hitz, Alexander Hoischen, Paul-Martin Holterhus, Wiebke Hülsemann, Kimia Kahrizi, Vera M. Kalscheuer, Anita Kan, Mandy Krumbiegel, Ingo Kurth, Jonas Leubner, Ann Carolin Longardt, Jörg D. Moritz, Hossein Najmabadi, Karolina Skipalova, Lot Snijders Blok, Andreas Tzschach, Eberhard Wiedersberg, Martin Zenker, Carla Garcia-Cabau, René Buschow, Xavier Salvatella, Matthew L. Kraushar, Stefan Mundlos, Almuth Caliebe, Malte Spielmann, Denise Horn, Denes Hnisz
Publikováno v:
Nature
Nature, 614, 7948, pp. 564-571
Nature, 614, 564-571
Nature, 614, 7948, pp. 564-571
Nature, 614, 564-571
Thousands of genetic variants in protein-coding genes have been linked to disease. However, the functional impact of most variants is unknown as they occur within intrinsically disordered protein regions that have poorly defined functions1–3. Intri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d44f81500de5059b7ca491edb8534c
http://hdl.handle.net/2445/200283
http://hdl.handle.net/2445/200283
Autor:
Shaon Basu, Paula Martínez-Cristóbal, Mireia Pesarrodona, Marta Frigolé-Vivas, Michael Lewis, Elzbieta Szulc, C. Adriana Bañuelos, Carolina Sánchez-Zarzalejo, Stasė Bielskutė, Jiaqi Zhu, Karina Pombo-García, Carla Garcia-Cabau, Cristina Batlle, Borja Mateos, Mateusz Biesaga, Albert Escobedo, Lídia Bardia, Xavier Verdaguer, Alessandro Ruffoni, Nasrin R. Mawji, Jun Wang, Teresa Tam, Isabelle Brun-Heath, Salvador Ventura, David Meierhofer, Jesús García, Paul Robustelli, Travis H. Stracker, Marianne D. Sadar, Antoni Riera, Denes Hnisz, Xavier Salvatella
SummaryTranscription factors are among the most attractive therapeutic targets but are considered largely undruggable due to the intrinsically disordered nature of their activation domains. Here we show that the aromatic character of the activation d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::647a49166ea017e1660f5ae923fe0668
https://doi.org/10.1101/2022.08.18.504385
https://doi.org/10.1101/2022.08.18.504385
Autor:
Neus Sanfeliu-Cerdán, Borja Mateos, Carla Garcia-Cabau, Frederic Català-Castro, Maria Ribera, Iris Ruider, Montserrat Porta-de-la-Riva, Stefan Wieser, Xavier Salvatella, Michael Krieg
A large body of work suggests that biomolecular condensates ensuing from liquid-liquid phase separation mature into various material states. How this aging process is controlled and if the naive and mature phases can have differential functions is cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c92d848e1b8385b7dc624203fd3b19e5
https://doi.org/10.1101/2022.07.08.499356
https://doi.org/10.1101/2022.07.08.499356
Autor:
Pablo Lujan, Carla Garcia-Cabau, Yuichi Wakana, Carmen Rodilla-Ramírez, Vivek Malhotra, Xavier Salvatella, Maria F. Garcia-Parajo, Felix Campelo
Secretory proteins are sorted at the trans-Golgi network (TGN) for export into specific transport carriers. However, the molecular players involved in this fundamental process remain largely elusive. Here, we identified the transmembrane protein TGN4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96519b64bda79e476ac67f2b0cb071cc
https://doi.org/10.1101/2022.04.20.488883
https://doi.org/10.1101/2022.04.20.488883
Autor:
Marie Christou-Kent, Sergi Cuartero, Julia Ruehle, Carla Garcia-Cabau, Julian Naderi, Marcos Plana-Carmona, Marc Alcoverro-Bertran, Luisa De Andres-Aguayo, Eric Julia, Xavier Salvatella, Denes Hnisz, Thomas Graf, Gregoire Stik
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13158c1057bb09c771dc14e0acae6942
https://doi.org/10.2139/ssrn.4156154
https://doi.org/10.2139/ssrn.4156154