Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Carla F. M. Molthoff"'
Autor:
Maarten M. Steinz, Aiarpi Ezdoglian, Fatemeh Khodadust, Carla F. M. Molthoff, Madduri Srinivasarao, Philip S. Low, Gerben J. C. Zwezerijnen, Maqsood Yaqub, Wissam Beaino, Albert D. Windhorst, Sander W. Tas, Gerrit Jansen, Conny J. van der Laken
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Non-invasive imaging modalities constitute an increasingly important tool in diagnostic and therapy response monitoring of patients with autoimmune diseases, including rheumatoid arthritis (RA). In particular, macrophage imaging with positron emissio
Externí odkaz:
https://doaj.org/article/029857162ef5491a9e59a32e5a1d6081
Autor:
Joost Verbeek, Jonas Eriksson, Stina Syvänen, Marc Huisman, Robert C. Schuit, Carla F. M. Molthoff, Rob A. Voskuyl, Elizabeth C. de Lange, Adriaan A. Lammertsma, Albert D. Windhorst
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 3, Iss 1, Pp 1-19 (2018)
Abstract Background Several P-glycoprotein (P-gp) substrate tracers are available to assess P-gp function in vivo, but attempts to develop a tracer for measuring expression levels of P-gp have not been successful. Recently, (Z)-2-(5-fluoro-2-oxoindol
Externí odkaz:
https://doaj.org/article/0ff9f80b10b94ad3b32f454b09b88ba8
Autor:
Durga M. S. H. Chandrupatla, Gerrit Jansen, Ricardo Vos, Mariska Verlaan, Qingshou Chen, Philip S. Low, Albert D. Windhorst, Adriaan A. Lammertsma, Conny J. van der Laken, Carla F. M. Molthoff
Publikováno v:
Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-9 (2017)
Abstract Background Folate receptor β (FRβ) is involved in facilitating cellular uptake of folates and anti-folates (such as methotrexate (MTX)). In rheumatoid arthritis, FRβ is expressed on synovial macrophages and recently has been explored as a
Externí odkaz:
https://doaj.org/article/5a885222fd434f019869ad0af1e3e335
Autor:
Renée C. G. de Bruin, John P. Veluchamy, Sinéad M. Lougheed, Famke L. Schneiders, Silvia Lopez-Lastra, Roeland Lameris, Anita G. Stam, Zsolt Sebestyen, Jürgen Kuball, Carla F. M. Molthoff, Erik Hooijberg, Rob C. Roovers, James P. Di Santo, Paul M. P. van Bergen en Henegouwen, Henk M. W. Verheul, Tanja D. de Gruijl, Hans J. van der Vliet
Publikováno v:
OncoImmunology, Vol 7, Iss 1 (2018)
Though Vγ9Vδ2-T cells constitute only a small fraction of the total T cell population in human peripheral blood, they play a vital role in tumor defense and are therefore of major interest to explore for cancer immunotherapy. Vγ9Vδ2-T cell-based
Externí odkaz:
https://doaj.org/article/7c5a3a971c7f40ea88934267608977f3
Autor:
Maroeska J. Burggraaf, Diane Houben, Coen Kuijl, Mariska Verlaan, J.J. Maaskant, Joen Luirink, Lisette Waanders, Carla F. M. Molthoff, Wilbert Bitter
Publikováno v:
Bladder Cancer, 7(1), 79-90. IOS Press
Burggraaf, M J, Waanders, L, Verlaan, M, Maaskant, J, Houben, D, Luirink, J, Bitter, W, Kuijl, C & Molthoff, C F M 2021, ' Surface Labeling with Adhesion Protein FimH Improves Binding of Immunotherapeutic Agent Salmonella Ty21a to the Bladder Epithelium ', Bladder Cancer, vol. 7, no. 1, pp. 79-90 . https://doi.org/10.3233/blc-200382, https://doi.org/10.3233/BLC-200382
Burggraaf, M J, Waanders, L, Verlaan, M, Maaskant, J, Houben, D, Luirink, J, Bitter, W, Kuijl, C & Molthoff, C F M 2021, ' Surface Labeling with Adhesion Protein FimH Improves Binding of Immunotherapeutic Agent Salmonella Ty21a to the Bladder Epithelium ', Bladder Cancer, vol. 7, no. 1, pp. 79-90 . https://doi.org/10.3233/BLC-200382
Burggraaf, M J, Waanders, L, Verlaan, M, Maaskant, J, Houben, D, Luirink, J, Bitter, W, Kuijl, C & Molthoff, C F M 2021, ' Surface Labeling with Adhesion Protein FimH Improves Binding of Immunotherapeutic Agent Salmonella Ty21a to the Bladder Epithelium ', Bladder Cancer, vol. 7, no. 1, pp. 79-90 . https://doi.org/10.3233/blc-200382, https://doi.org/10.3233/BLC-200382
Burggraaf, M J, Waanders, L, Verlaan, M, Maaskant, J, Houben, D, Luirink, J, Bitter, W, Kuijl, C & Molthoff, C F M 2021, ' Surface Labeling with Adhesion Protein FimH Improves Binding of Immunotherapeutic Agent Salmonella Ty21a to the Bladder Epithelium ', Bladder Cancer, vol. 7, no. 1, pp. 79-90 . https://doi.org/10.3233/BLC-200382
BACKGROUND: Bladder cancer is the ninth most common cancer in men. 70% of these tumors are classified as non-muscle invasive bladder cancer and those patients receive 6 intravesical instillations with Mycobacterium bovis BCG after transurethral resec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f99173ae400ed56af37971eec3203de9
https://doi.org/10.3233/blc-200382
https://doi.org/10.3233/blc-200382
Autor:
Carla F. M. Molthoff, John S Yudkin, Erik M. van Poelgeest, Marie-José Goumans, Etto C. Eringa, Alexander H. Turaihi, E.H. Serné, Victor W.M. van Hinsbergh, Jasper J. Koning, Hans W.M. Niessen, Yvo M. Smulders, Jaco C. Knol, Connie R. Jimenez
Publikováno v:
Turaihi, A H, Serné, E H, Molthoff, C F M, Koning, J J, Knol, J, Niessen, H W, Jose Th Goumans, M, van Poelgeest, E M, Yudkin, J S, Smulders, Y M, Jimenez, C R, van Hinsbergh, V W & Eringa, E C 2020, ' Perivascular Adipose Tissue Controls Insulin-Stimulated Perfusion, Mitochondrial Protein Expression and Glucose Uptake in Muscle Through Adipomuscular Arterioles ', Diabetes, vol. 69, no. 4, pp. 603-613 . https://doi.org/10.2337/db18-1066
Diabetes, 69(4), 603-613. American Diabetes Association Inc.
Diabetes, 69(4), 603-613. AMER DIABETES ASSOC
Diabetes, 69(4), 603-613. American Diabetes Association Inc.
Diabetes, 69(4), 603-613. AMER DIABETES ASSOC
Insulin-mediated microvascular recruitment (IMVR) regulates delivery of insulin and glucose to insulin-sensitive tissues. We have previously proposed that perivascular adipose tissue (PVAT) controls vascular function through outside-to-inside communi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4a3963814eb4acf3717bc7678f5c001
https://doi.org/10.2337/db18-1066
https://doi.org/10.2337/db18-1066
Autor:
Gerrit Jansen, Conny J. van der Laken, Durga M.S.H. Chandrupatla, Adriaan A. Lammertsma, Carla F. M. Molthoff
Publikováno v:
Chandrupatla, D M S H, Molthoff, C F M, Lammertsma, A A, van der Laken, C J & Jansen, G 2019, ' The folate receptor β as a macrophage-mediated imaging and therapeutic target in rheumatoid arthritis ', Drug delivery and translational research, vol. 9, no. 1, pp. 366-378 . https://doi.org/10.1007/s13346-018-0589-2
Drug Delivery and Translational Research
Drug Delivery and Translational Research
Macrophages play a key role in the pathophysiology of rheumatoid arthritis (RA). Notably, positive correlations have been reported between synovial macrophage infiltration and disease activity as well as therapy outcome in RA patients. Hence, macroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba6aa5d10703c7a894dc3388c1f33d2
http://www.scopus.com/inward/record.url?scp=85059828076&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85059828076&partnerID=8YFLogxK
Autor:
Torsten Dreier, Sang We Kim, Christophe Borg, Peter Verheesen, Carla F. M. Molthoff, Philippe Barthélémy, Danielle J. Vugts, Paolo Michieli, Keunchil Park, Guus A.M.S. van Dongen, Luc Van Rompaey, Do Youn Oh, Natalie De Jonge, Karen Zwanenpoel, Christian Rolfo, Philippe Aftimos, Nicolas Leupin, Alain Thibault, Ahmad Awada, Sylvie Rottey, Valérie Hanssens, Julie Jacobs, Samson Fung, Patrick Pauwels, Hans de Haard, Anna Hultberg
Publikováno v:
Biomedicines
Biomedicines, Vol 9, Iss 665, p 665 (2021)
BIOMEDICINES
Biomedicines, 9(6). MDPI AG
Biomedicines, 9(6):665. MDPI AG
Biomedicines, 9 (6
Aftimos, P, Rolfo, C, Rottey, S, Barthélémy, P, Borg, C, Park, K, Oh, D-Y, Kim, S-W, de Jonge, N, Hanssens, V, Zwanenpoel, K, Molthoff, C, Vugts, D, Dreier, T, Verheesen, P, van Dongen, G A M S, Jacobs, J, van Rompaey, L, Hultberg, A, Michieli, P, Pauwels, P, Fung, S, Thibault, A, de Haard, H, Leupin, N & Awada, A 2021, ' The nhance® mutation-equipped anti-met antibody argx-111 displays increased tissue penetration and anti-tumor activity in advanced cancer patients ', Biomedicines, vol. 9, no. 6, 665 . https://doi.org/10.3390/biomedicines9060665
Volume 9
Issue 6
Biomedicines, Vol 9, Iss 665, p 665 (2021)
BIOMEDICINES
Biomedicines, 9(6). MDPI AG
Biomedicines, 9(6):665. MDPI AG
Biomedicines, 9 (6
Aftimos, P, Rolfo, C, Rottey, S, Barthélémy, P, Borg, C, Park, K, Oh, D-Y, Kim, S-W, de Jonge, N, Hanssens, V, Zwanenpoel, K, Molthoff, C, Vugts, D, Dreier, T, Verheesen, P, van Dongen, G A M S, Jacobs, J, van Rompaey, L, Hultberg, A, Michieli, P, Pauwels, P, Fung, S, Thibault, A, de Haard, H, Leupin, N & Awada, A 2021, ' The nhance® mutation-equipped anti-met antibody argx-111 displays increased tissue penetration and anti-tumor activity in advanced cancer patients ', Biomedicines, vol. 9, no. 6, 665 . https://doi.org/10.3390/biomedicines9060665
Volume 9
Issue 6
Dysregulation of MET signaling has been implicated in tumorigenesis and metastasis. ARGX-111 combines complete blockade of this pathway with enhanced tumor cell killing and was investigated in 24 patients with MET-positive advanced cancers in a phase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7904fc2d1870462cb38bee26c2d85ac0
https://hdl.handle.net/10067/1796840151162165141
https://hdl.handle.net/10067/1796840151162165141
Autor:
Danielle J. Vugts, Margherita Vaselli, Carla F. M. Molthoff, Helene Knaus, Valentina Davidoiu, Fabio Feroldi, Guus A.M.S. van Dongen, Johannes F. de Boer, Mariska Verlaan
Publikováno v:
Feroldi, F, Vaselli, M, Verlaan, M, Knaus, H, Davidoiu, V, Vugts, D, Molthoff, C, van Dongen, G & de Boer, J F 2020, ' Combined structural and molecular imaging using optical coherence tomography and immunofluorescence imaging (Conference Presentation) ', Paper presented at SPIE BiOS 2020, San Francisco, United States, 1/02/20-6/02/20 . https://doi.org/10.1117/12.2545222
SPIE BiOS 2020
SPIE BiOS 2020
Imaging the heterogeneity of the tumor microenvironment is thought to be valuable for assessing the efficacy of a cancer therapy. However, due to the insufficient resolution of clinically available molecular imaging tools such as positron emission to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e58a6a7d34cae71c195dcdb29b822645
https://doi.org/10.1117/12.2545222
https://doi.org/10.1117/12.2545222
Autor:
René J. P. Musters, Conny J. van der Laken, Eline Elshof, Carla F. M. Molthoff, Adriaan A. Lammertsma, Ruud Brands, Philip S. Low, Durga M.S.H. Chandrupatla, Gerrit Jansen, Wayne I.G.R. Ritsema, Ricardo Vos, Takami Matsuyama, Albert D. Windhorst, Anthony Hammond
Publikováno v:
Translational research : the journal of laboratory and clinical medicine, 199, 24-38. Mosby Inc.
Chandrupatla, D M S H, Molthoff, C F M, Ritsema, W I G R, Vos, R, Elshof, E, Matsuyama, T, Low, P S, Musters, R J P, Hammond, A, Windhorst, A D, Lammertsma, A A, van der Laken, C J, Brands, R & Jansen, G 2018, ' Prophylactic and therapeutic activity of alkaline phosphatase in arthritic rats : single-agent effects of alkaline phosphatase and synergistic effects in combination with methotrexate ', Translational research : the journal of laboratory and clinical medicine, vol. 199, pp. 24-38 . https://doi.org/10.1016/j.trsl.2018.04.001
Chandrupatla, D M S H, Molthoff, C F M, Ritsema, W I G R, Vos, R, Elshof, E, Matsuyama, T, Low, P S, Musters, R J P, Hammond, A, Windhorst, A D, Lammertsma, A A, van der Laken, C J, Brands, R & Jansen, G 2018, ' Prophylactic and therapeutic activity of alkaline phosphatase in arthritic rats : single-agent effects of alkaline phosphatase and synergistic effects in combination with methotrexate ', Translational research : the journal of laboratory and clinical medicine, vol. 199, pp. 24-38 . https://doi.org/10.1016/j.trsl.2018.04.001
Alkaline phosphatase (AP) is a gate-keeper of innate immune system responses by detoxifying inflammation triggering moieties released from endogenous and external sources. We examined whether AP's broad mechanism of action constitutes a safe therapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb64bce916dc88a7fa3b497d652eb6ec
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85048262087&origin=inward
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85048262087&origin=inward