SPCS1-Dependent E2-p7 processing determines HCV Assembly efficiency.

Autor: Nabeel Alzahrani, Ming-Jhan Wu, Carla F Sousa, Olga V Kalinina, Christoph Welsch, MinKyung Yi

Publikováno v: PLoS Pathogens, Vol 18, Iss 2, p e1010310 (2022)

Recent studies identified signal peptidase complex subunit 1 (SPCS1) as a proviral host factor for Flaviviridae viruses, including HCV. One of the SPCS1's roles in flavivirus propagation was attributed to its regulation of signal peptidase complex (S

Externí odkaz: https://doaj.org/article/36203eaed4a44cc0af0cc0dd5fb3b002

Modeling the Effect of Hydrophobicity on the Passive Permeation of Solutes across a Bacterial Model Membrane

Autor: Carla F. Sousa, Mohamed A.M. Kamal, Robert Richter, Kalanika Elamaldeniya, Rolf W. Hartmann, Martin Empting, Claus-Michael Lehr, Olga V. Kalinina

Publikováno v: Journal of chemical information and modeling. 62(20)

Passive diffusion across biomembranes is an important mechanism of permeation for multiple drugs, including antibiotics. However, this process is frequently neglected while studying drug uptake and, in our view, warrants further investigation. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d6d3d6869117b96ca92190c0b39ed5e
https://pubmed.ncbi.nlm.nih.gov/36214845

Exploring the permeation of fluoroquinolone metalloantibiotics across outer membrane porins by combining molecular dynamics simulations and a porin-mimetic in vitro model

Autor: Carla F. Sousa, João T.S. Coimbra, Robert Richter, João H. Morais-Cabral, Maria J. Ramos, Claus-Michael Lehr, Pedro A. Fernandes, Paula Gameiro

Publikováno v: Biochimica et biophysica acta. Biomembranes
Netherlands

The misuse and overuse of fluoroquinolones in recent years have triggered alarming levels of resistance to these antibiotics. Porin channels are crucial for the permeation of fluoroquinolones across the outer membrane of Gram-negative bacteria and mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b8a30677455626e152ff5561de4c63
https://pubmed.ncbi.nlm.nih.gov/34896074

Fluoroquinolone metalloantibiotics: A promising approach against methicillin-resistant staphylococcus aureus

Autor: Dafne Bongiorno, Paula Gameiro, Carla F. Sousa, Stefania Stefani, Lucinda J. Bessa, Floriana Campanile, Mariana Simões Larraz Ferreira, Peter Eaton

Publikováno v: International Journal of Environmental Research and Public Health, Vol 17, Iss 3127, p 3127 (2020)
International Journal of Environmental Research and Public Health
Volume 17
Issue 9

Fluoroquinolones (FQs) are antibiotics commonly used in clinical practice, although nowadays they are becoming ineffective due to the emergence of several mechanisms of resistance in most bacteria. The complexation of FQs with divalent metal ions and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cdce2eeac2b0c24318f15ffa67a2e13
http://hdl.handle.net/20.500.11769/420542

How Insertion of a Single Tryptophan in the N-Terminus of a Cecropin A-Melittin Hybrid Peptide Changes Its Antimicrobial and Biophysical Profile

Autor: Paula Gameiro, Carla F. Sousa, Paula Gomes, Cátia Teixeira, Lucinda J. Bessa, Ana Rita Ferreira

Publikováno v: Membranes
Switzerland
Membranes, Vol 11, Iss 48, p 48 (2021)
Volume 11
Issue 1

In the era of antibiotic resistance, there is an urgent need for efficient antibiotic therapies to fight bacterial infections. Cationic antimicrobial peptides (CAMP) are promising lead compounds given their membrane-targeted mechanism of action, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d71c55568071aebbc9bb32b5bae0a2
https://doi.org/10.3390/membranes11010048