Zobrazeno 1 - 10 of 118 pro vyhledávání: '"Carla F, Kim"'
1
Akademický článek
PR1P, a VEGF-stabilizing peptide, reduces injury and inflammation in acute lung injury and ulcerative colitis animal models
Autor: Avner Adini, Victoria H. Ko, Mark Puder, Sharon M. Louie, Carla F. Kim, Joseph Baron, Benjamin D. Matthews
Publikováno v: Frontiers in Immunology, Vol 14 (2023)
Acute Respiratory Distress Syndrome (ARDS) and Ulcerative Colitis (UC) are each characterized by tissue damage and uncontrolled inflammation. Neutrophils and other inflammatory cells play a primary role in disease progression by acutely responding to
Externí odkaz: https://doaj.org/article/339d572eadb94e5ba9fa0e9203652e8e
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2
Akademický článek
Culture impact on the transcriptomic programs of primary and iPSC-derived human alveolar type 2 cells
Autor: Konstantinos-Dionysios Alysandratos, Carolina Garcia-de-Alba, Changfu Yao, Patrizia Pessina, Jessie Huang, Carlos Villacorta-Martin, Olivia T. Hix, Kasey Minakin, Claire L. Burgess, Pushpinder Bawa, Aditi Murthy, Bindu Konda, Michael F. Beers, Barry R. Stripp, Carla F. Kim, Darrell N. Kotton
Publikováno v: JCI Insight, Vol 8, Iss 1 (2023)
Dysfunction of alveolar epithelial type 2 cells (AEC2s), the facultative progenitors of lung alveoli, is implicated in pulmonary disease pathogenesis, highlighting the importance of human in vitro models. However, AEC2-like cells in culture have yet
Externí odkaz: https://doaj.org/article/f25a0ef19189460ebd6f7a2ad18d270c
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3
Akademický článek
Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell–derived alveolar epithelium
Autor: Kristine M. Abo, Julio Sainz de Aja, Jonathan Lindstrom-Vautrin, Konstantinos-Dionysios Alysandratos, Alexsia Richards, Carolina Garcia-de-Alba, Jessie Huang, Olivia T. Hix, Rhiannon B. Werder, Esther Bullitt, Anne Hinds, Isaac Falconer, Carlos Villacorta-Martin, Rudolf Jaenisch, Carla F. Kim, Darrell N. Kotton, Andrew A. Wilson
Publikováno v: JCI Insight, Vol 7, Iss 6 (2022)
Type 2 alveolar epithelial cells (AT2s), facultative progenitor cells of the lung alveolus, play a vital role in the biology of the distal lung. In vitro model systems that incorporate human cells, recapitulate the biology of primary AT2s, and interf
Externí odkaz: https://doaj.org/article/42389eda8ce941c3bc455d6c05c41b76
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4
Akademický článek
SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery
Autor: Apoorva Mulay, Bindu Konda, Gustavo Garcia, Jr., Changfu Yao, Stephen Beil, Jaquelyn M. Villalba, Colin Koziol, Chandani Sen, Arunima Purkayastha, Jay. K. Kolls, Derek A. Pociask, Patrizia Pessina, Julio Sainz de Aja, Carolina Garcia-de-Alba, Carla F. Kim, Brigitte Gomperts, Vaithilingaraja Arumugaswami, Barry R. Stripp
Publikováno v: Cell Reports, Vol 35, Iss 5, Pp 109055- (2021)
Summary: Coronavirus disease 2019 (COVID-19) is the latest respiratory pandemic caused by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). Although infection initiates in the proximal airways, severe and sometimes fatal symptoms
Externí odkaz: https://doaj.org/article/c6b335eff48e42068ebd55ba5f9b3751
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5
Akademický článek
Human amnion cells reverse acute and chronic pulmonary damage in experimental neonatal lung injury
Autor: Dandan Zhu, Jean Tan, Amina S. Maleken, Ruth Muljadi, Siow T. Chan, Sin N. Lau, Kirstin Elgass, Bryan Leaw, Joanne Mockler, Daniel Chambers, Kristen T. Leeman, Carla F. Kim, Euan M. Wallace, Rebecca Lim
Publikováno v: Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-24 (2017)
Abstract Background Despite advances in neonatal care, bronchopulmonary dysplasia (BPD) remains a significant contributor to infant mortality and morbidity. While human amnion epithelial cells (hAECs) have shown promise in small and large animal mode
Externí odkaz: https://doaj.org/article/493b4a491b494e05afb89c2556933b38
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6
Akademický článek
Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2
Autor: Haikuo Zhang, Christine Fillmore Brainson, Shohei Koyama, Amanda J. Redig, Ting Chen, Shuai Li, Manav Gupta, Carolina Garcia-de-Alba, Margherita Paschini, Grit S. Herter-Sprie, Gang Lu, Xin Zhang, Bryan P. Marsh, Stephanie J. Tuminello, Chunxiao Xu, Zhao Chen, Xiaoen Wang, Esra A. Akbay, Mei Zheng, Sangeetha Palakurthi, Lynette M. Sholl, Anil K. Rustgi, David J. Kwiatkowski, J Alan Diehl, Adam J. Bass, Norman E. Sharpless, Glenn Dranoff, Peter S. Hammerman, Hongbin Ji, Nabeel Bardeesy, Dieter Saur, Hideo Watanabe, Carla F. Kim, Kwok-Kin Wong
Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
The mechanisms that govern the transdifferentiation of lung adenocarcinomas (ADC) to squamous cell carcinoma (SCC) are not fully understood. Here, the authors show that EZH2 loss exacerbates the transdifferentiation of ADCs to SCCs as a result of chr
Externí odkaz: https://doaj.org/article/0ce62822a53e4bae828250fb78660d57
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