Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Carla Caccia"'
Publikováno v:
Journal of Clinical Neuroscience. 90:178-183
Glutamate is the major excitatory neurotransmitter in the central nervous system and, as such, many brain regions, including the basal ganglia, are rich in glutamatergic neurons. The importance of the basal ganglia in the control of voluntary movemen
Autor:
Maria Rosaria Carratù, Concetta Altamura, Gloria Padoani, Paola Imbrici, Elsa Melloni, Michela De Bellis, Sabata Pierno, Alessandro Farinato, Jean-François Desaphy, Silvia Vailati, Charlotte Keywood, Diana Conte, Nancy Tarantino, Annamaria De Luca, Carla Caccia
Publikováno v:
Experimental neurology. 328
The antiarrhythmic sodium-channel blocker mexiletine is used to treat patients with myotonia. However, around 30% of patients do not benefit from mexiletine due to poor tolerability or suboptimal response. Safinamide is an add-on therapy to levodopa
Autor:
Michele Morari, Elsa Melloni, Carla Caccia, Alberto Brugnoli, Salvatore Novello, Silvia Vailati, Charlotte Keywood, Gloria Padoani, Clarissa Anna Pisanò
Publikováno v:
Neuropharmacology. 167:108006
To investigate whether the reversible MAO-B inhibitor and sodium channel blocker safinamide impairs glutamate release under parkinsonian conditions in vivo, and this effect is dependent on MAO-B inhibition, safinamide (and rasagiline as a comparator)
Autor:
Elsa Melloni, James Kulisevsky, Clarissa Anna Pisanò, Michele Morari, Fabrizio Gardoni, Gloria Padoani, Carla Caccia, Salvatore Novello, Andrea Brugnoli, Silvia Vailati, Manuela Mellone, Victoria Sosti, Charlotte Keywood
Publikováno v:
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Safinamide (Xadago) is a novel dual-mechanism drug that has been approved in the European Union and United States as add-on treatment to levodopa in Parkinson's disease therapy. In addition to its selective and reversible monoamine oxidase B inhibiti
Autor:
Matthew Pangborn, Laura P. Svetkey, Corrine I. Voils, Tony Lazenka, Crystal C. Tyson, Jacqueline Bagwell, Steven C. Grambow, Jasmine Burroughs, Bryan C. Batch, Gary G. Bennett, Kate Pilewski, Rachel Bordogna, Carla Caccia, Aziza Sutton, Hayden B. Bosworth, Stephen S. Intille, Pao-Hwa Lin, Leonor Corsino, Jenifer Schwager
Publikováno v:
Contemporary Clinical Trials. 37:333-341
The obesity epidemic has spread to young adults, leading to significant public health implications later in adulthood. Intervention in early adulthood may be an effective public health strategy for reducing the long-term health impact of the epidemic
Autor:
M. De Bellis, Sabata Pierno, Silvia Vailati, Diana Conte, Jean-François Desaphy, Paola Imbrici, Carla Caccia, Gloria Padoani, Elsa Melloni, Alessandro Farinato, Concetta Altamura, Charlotte Keywood
Publikováno v:
Journal of the Neurological Sciences. 405:10
Autor:
Patrick Smith, Alan L. Hinderliter, Julie Johnson, Linda W. Craighead, James A. Blumenthal, Andrew Sherwood, Dawn E. Epstein, Pao-Hwa Lin, Michael A. Babyak, Carla Caccia
Publikováno v:
Journal of the Academy of Nutrition and Dietetics. 112:1763-1773
Background Although the Dietary Approaches to Stop Hypertension (DASH) diet is an accepted nonpharmacologic treatment for hypertension, little is known about what patient characteristics affect dietary adherence and what level of adherence is needed
Autor:
M.V. Sosti, M. Morari, A. Brugnoli, M. Mellone, J. Kulisevsky, Silvia Vailati, Gloria Padoani, Elsa Melloni, F. Gardoni, Charlotte Keywood, Carla Caccia
Publikováno v:
Journal of the Neurological Sciences. 381:361-362
Autor:
Leonardo Pisani, Orazio Nicolotti, Céline Le Bourdonnec Passeleu, Angelo Carotti, Carla Caccia, Patricia Salvati, Francesco Leonetti, Giovanni Muncipinto, Teresa Fabiola Miscioscia, Ramón Soto-Otero, Estefanía Méndez-Álvarez, Marco Catto
Publikováno v:
Journal of Medicinal Chemistry. 52:6685-6706
In an effort to discover novel selective monoamine oxidase (MAO) B inhibitors with favorable physicochemical and pharmacokinetic profiles, 7-[(m-halogeno)benzyloxy]coumarins bearing properly selected polar substituents at position 4 were designed, sy
Autor:
Angela Stefanachi, Giovanni Muncipinto, Carmelida Capaldi, Orazio Nicolotti, Saverio Cellamare, Francesco Leonetti, Carla Caccia, Leonardo Pisani, Angelo Carotti
Publikováno v:
Journal of Medicinal Chemistry. 50:4909-4916
Safinamide, (S)-N2-{4-[(3-fluorobenzyl)oxy]benzyl}alaninamide methanesulfonate, which is in phase III clinical trials as an anti-Parkinson drug, and a library of alkanamidic analogues were prepared through an expeditious solid-phase synthesis and eva