Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Carla Bradshaw"'
Autor:
Elizaveta A. Olkhova, Carla Bradshaw, Alasdair Blain, Debora Alvim, Doug M. Turnbull, Fiona E. N. LeBeau, Yi Shiau Ng, Gráinne S. Gorman, Nichola Z. Lax
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
Abstract Mitochondrial diseases comprise a common group of neurometabolic disorders resulting from OXPHOS defects, that may manifest with neurological impairments, for which there are currently no disease-modifying therapies. Previous studies suggest
Externí odkaz:
https://doaj.org/article/d905e99197394a9cbdda0d8fb7b9226c
Autor:
Elizaveta A. Olkhova, Laura A. Smith, Carla Bradshaw, Gráinne S. Gorman, Daniel Erskine, Yi Shiau Ng
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9698 (2023)
Mitochondrial diseases represent the most common inherited neurometabolic disorders, for which no effective therapy currently exists for most patients. The unmet clinical need requires a more comprehensive understanding of the disease mechanisms and
Externí odkaz:
https://doaj.org/article/c8af4461a80648d7974e632b4da60332
Autor:
Xuefei Yu, Catherine Arden, Rolando Berlinguer-Palmini, Chun Chen, Carla Bradshaw, Anna LM Smith, Julia Whitehall, Michael White, Scott Anderson, Nicole Kattner, James Shaw, Doug Turnbull, Laura C Greaves, Mark Walker
Publikováno v:
Molecular Metabolism, Vol 60, Iss , Pp 101489- (2022)
Objective: There is strong evidence that mitochondrial DNA mutations and mitochondrial dysfunction play a role in diabetes pathogenesis. The homozygous knock-in mtDNA mutator mouse is a model of premature aging due to the accumulation of mitochondria
Externí odkaz:
https://doaj.org/article/7ed661841b25429ebf527135df0d42bd
Autor:
Anna L. M. Smith, Carla Bradshaw, Julia C. Whitehall, Craig Stamp, Laura C. Greaves, Douglass M. Turnbull, Elizabeth A. Stoll, David Houghton, Alasdair P. Blain
Publikováno v:
Aging Cell
One of the hallmarks of aging is an accumulation of cells with defects in oxidative phosphorylation (OXPHOS) due to mutations of mitochondrial DNA (mtDNA). Rapidly dividing tissues maintained by stem cells, such as the colonic epithelium, are particu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d920318caac25221909869bf3afaf7c
https://doi.org/10.1111/acel.13321
https://doi.org/10.1111/acel.13321
Autor:
Anna L. M. Smith, Julia C. Whitehall, Carla Bradshaw, David Gay, Fiona Robertson, Alasdair P. Blain, Gavin Hudson, Angela Pyle, David Houghton, Matthew Hunt, James N. Sampson, Craig Stamp, Grace Mallett, Shoba Amarnath, Jack Leslie, Fiona Oakley, Laura Wilson, Angela Baker, Oliver M. Russell, Riem Johnson, Claire A. Richardson, Bhavana Gupta, Iain McCallum, Stuart A. C. McDonald, Seamus Kelly, John C. Mathers, Rakesh Heer, Robert W. Taylor, Neil D. Perkins, Doug M. Turnbull, Owen J. Sansom, Laura C. Greaves
Publikováno v:
Nat Cancer
Oxidative phosphorylation (OXPHOS) defects caused by somatic mitochondrial DNA (mtDNA) mutations increase with age in human colorectal epithelium and are prevalent in colorectal tumours, but whether they actively contribute to tumorigenesis remains u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8307dc672e870d72fe4e13a7b26978cb
https://pubmed.ncbi.nlm.nih.gov/35121898
https://pubmed.ncbi.nlm.nih.gov/35121898
Autor:
Jennifer L Lofgren, Claudia Chui Shan Lee, Paul A. Flecknell, Carla Bradshaw, Amy L. Miller, Johnny V Roughan
Publikováno v:
Laboratory Animals
Murine orthotopic cancer models often require surgery, potentially causing pain or distress. However, analgesics are often withheld because they may alter tumour development. Two orthotopically implanted cancers were investigated in mice pre-treated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01c94a74374a547eb32d9f17f553abf
https://doi.org/10.1177/0023677217739934
https://doi.org/10.1177/0023677217739934
Autor:
James Shaw, Carla Bradshaw, Julia C. Whitehall, Douglass M. Turnbull, Mark Walker, Xuefei Yu, Scott J. Anderson, Catherine Arden, Michael G. White, Laura C. Greaves, Chun Chen
Publikováno v:
Diabetes. 68
Introduction: Age-related cumulative mitochondrial mutations can cause mitochondrial dysfunction. The mitochondrial DNA mutator mouse (PolgAmut/mut) is a model of premature ageing and has been previously shown to develop impaired insulin secretion wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e4f262692e467511ac2c30e6166f500
https://doi.org/10.2337/db19-333-lb
https://doi.org/10.2337/db19-333-lb
Autor:
Daniel Hipps, Anna L. M. Smith, David J. Deehan, Amy K. Reeve, Ella P. Dennis, Carla Bradshaw, Laura C. Greaves, Douglass M. Turnbull, Alex Laude, Philip F. Dobson, Craig Stamp
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
The pathogenesis of declining bone mineral density, a universal feature of ageing, is not fully understood. Somatic mitochondrial DNA (mtDNA) mutations accumulate with age in human tissues and mounting evidence suggests that they may be integral to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305964c1935340c4eb162267eb9bb280