Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Carla B. Washington"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 6, Pp 698-710 (2022)
Abstract Sickle cell disease (SCD) is characterized by the production of sickle hemoglobin (HbS), which when deoxygenated, polymerizes leading to red blood cell damage and hemolytic anemia, a defining feature of SCD. Voxelotor (Oxbryta) is a small mo
Externí odkaz:
https://doaj.org/article/6c72c21a581d402dbe39f18f86468896
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 6, Pp 687-697 (2022)
Abstract Oxbryta (voxelotor) is a small‐molecule inhibitor of sickle hemoglobin (Hb) polymerization approved for patients with sickle cell disease (SCD) aged greater than or equal to 12 years at a dose of 1500 mg once daily (q.d.). Voxelotor binds
Externí odkaz:
https://doaj.org/article/c5a3ffb8db6a464e9e1580276bea5028
Autor:
Mark J. Dresser, Kathleen M. Giacomini, Juan Wang, Carla B. Washington, Marci E. Schaner, Sheng-Fang Su
Publikováno v:
American Journal of Physiology-Renal Physiology. 273:F1058-F1065
Many purine nucleosides and their analogs are actively transported in the kidney. Using homology cloning strategies and reverse transcriptase-polymerase chain reactions, we isolated a cDNA encoding a Na+-dependent nucleoside transporter, hSPNT1, from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1cbf6511752da65c949cc1b783a717
https://doi.org/10.1152/ajprenal.1997.273.6.f1058
https://doi.org/10.1152/ajprenal.1997.273.6.f1058
Publikováno v:
Journal of Biological Chemistry. 270:22816-22819
The overall goal of this study was to determine the mechanisms by which nucleobases are transported in the choroid plexus. Choroid plexus tissue slices were obtained from the lateral ventricles of rabbit brains and depleted of ATP with 2,4-dinitrophe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abe4bd12b5b75b0aae3b0af168319a2a
https://doi.org/10.1074/jbc.270.39.22816
https://doi.org/10.1074/jbc.270.39.22816
Autor:
Ronda J. Ott, Kathleen M. Giacomini, Marcelo M. Gutierrez, Claire M. Brett, Carla B. Washington
Publikováno v:
Pharmaceutical Research. 10:423-426
The therapeutic efficacy of nucleosides and nucleoside analogues as antitumor, antiviral, antiparasitic, and antiarrhythmic agents has been well documented. Pharmacokinetic studies suggest that many of these compounds are actively transported in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c008a163906cddb96b47d151d8d599ec
https://doi.org/10.1023/a:1018948608211
https://doi.org/10.1023/a:1018948608211
Publikováno v:
Pharmaceutical Research. 15:1145-1147
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31318469632bab3128e3e95e28b5c846
https://doi.org/10.1023/a:1011963102063
https://doi.org/10.1023/a:1011963102063
Publikováno v:
Pharmaceutical Research. 13:1276-1278
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec4057e59e4b21811cabc848036ef239
https://doi.org/10.1023/a:1016041009856
https://doi.org/10.1023/a:1016041009856
Autor:
Judith A. Aberg, Charles Flexner, Lewis B. Sheiner, Carla B. Washington, Terrence F. Blaschke, Yoninah Segal, Susan L. Rosenkranz
Publikováno v:
Clinical pharmacology and therapeutics. 73(5)
Objective The aim of this study was to determine whether pharmacokinetic interactions between the protease inhibitors saquinavir soft gel, nelfinavir, and ritonavir are affected by the timing of administration. Study design We used an open-label, 6-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91757e16227d80877d8e72e441568b36
https://pubmed.ncbi.nlm.nih.gov/12732841
https://pubmed.ncbi.nlm.nih.gov/12732841
Publikováno v:
Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association. 19(3)
The anti-HIV protease inhibitors represent a new class of agents for treatment of HIV infection. Saquinavir, ritonavir, indinavir, and nelfinavir are the first drugs approved in this class and significantly reduce HIV RNA copy number with minimal adv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d6293c3c991922ee4b283e5da5dc95
https://pubmed.ncbi.nlm.nih.gov/9803961
https://pubmed.ncbi.nlm.nih.gov/9803961
Publikováno v:
Pharmaceutical Biotechnology ISBN: 9781489918659
The choroid plexuses, which comprise the blood-cerebrospinal fluid (CSF) barrier, are situated within the third, fourth, and lateral cerebral ventricles (Fig. 1). The choroid plexus functions in the secretion and reabsorption of a variety of compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c69a6d09bd65650f292a35a4e31280d
https://doi.org/10.1007/978-1-4899-1863-5_14
https://doi.org/10.1007/978-1-4899-1863-5_14
