Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Carla B, Green"'
Misaligned feeding uncouples daily rhythms within brown adipose tissue and between peripheral clocks
Autor:
Victoria A. Acosta-Rodríguez, Filipa Rijo-Ferreira, Laura van Rosmalen, Mariko Izumo, Noheon Park, Chryshanthi Joseph, Chelsea Hepler, Anneke K. Thorne, Jeremy Stubblefield, Joseph Bass, Carla B. Green, Joseph S. Takahashi
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114523- (2024)
Summary: Extended food consumption during the rest period perturbs the phase relationship between circadian clocks in the periphery and the brain, leading to adverse health effects. Beyond the liver, how metabolic organs respond to a timed hypocalori
Externí odkaz:
https://doaj.org/article/4031d2ffc75246fea67e5389eb202e45
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Circadian clocks link physiologic processes to environmental conditions and a mismatch between internal and external rhythms has negative effects on organismal health. In this review, the authors discuss the interactions between circadian clocks and
Externí odkaz:
https://doaj.org/article/137e79eb57704d35b67889343aad3b44
Autor:
Yasemin Onder, Isara Laothamatas, Stefano Berto, Katharina Sewart, Gokhul Kilaru, Bogdan Bordieanu, Jeremy J. Stubblefield, Genevieve Konopka, Prashant Mishra, Carla B. Green
Publikováno v:
iScience, Vol 19, Iss , Pp 83-92 (2019)
Summary: Fine-tuning of transcriptional responses can be critical for long-term outcomes in response to an environmental challenge. The circadian protein Nocturnin belongs to a family of proteins that include exonucleases, endonucleases, and phosphat
Externí odkaz:
https://doaj.org/article/9ad9f6c4ab354745b2182dc538214cf9
Autor:
Kazunari Nohara, Venkata Mallampalli, Travis Nemkov, Marvin Wirianto, Jiah Yang, Youqiong Ye, Yuxiang Sun, Leng Han, Karyn A. Esser, Eugenia Mileykovskaya, Angelo D’Alessandro, Carla B. Green, Joseph S. Takahashi, William Dowhan, Seung-Hee Yoo, Zheng Chen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The small molecule Nobiletin enhances circadian rhythms and protects against obesity-associated metabolic dysfunction in mice. Here the authors test its effect on health and lifespan, reporting that circadian enhancement promotes fitness and healthy
Externí odkaz:
https://doaj.org/article/a785be3a47764eeebef82872ff3d00a8
Autor:
Clark Rosensweig, Kimberly A. Reynolds, Peng Gao, Isara Laothamatas, Yongli Shan, Rama Ranganathan, Joseph S. Takahashi, Carla B. Green
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The molecular mechanisms that define the periodicity or rate of the circadian clock are not well understood. Here the authors use a multidisciplinary approach and identify a mechanism for period regulation that depends on the affinity of the core clo
Externí odkaz:
https://doaj.org/article/65074cf0d73e41918a1780ff7d99d766
Autor:
Jeremy J. Stubblefield, Peng Gao, Gokhul Kilaru, Bilal Mukadam, Jeremy Terrien, Carla B. Green
Publikováno v:
Cell Reports, Vol 22, Iss 5, Pp 1225-1235 (2018)
Summary: The timing of food intake and nutrient utilization is critical to health and regulated partly by the circadian clock. Increased amplitude of circadian oscillations and metabolic output has been found to improve health in diabetic and obesity
Externí odkaz:
https://doaj.org/article/6ecd435b9f5f4e0b97aa824b76bda639
Autor:
Yasemin Onder, Carla B. Green
Publikováno v:
Neurobiology of Sleep and Circadian Rhythms, Vol 4, Iss , Pp 57-63 (2018)
Circadian clocks synchronize the daily functions of organisms with environmental cues like light-dark cycles and feeding rhythms. The master clock in the suprachiasmatic nucleus in the hypothalamus of the brain and the many clocks in the periphery ar
Externí odkaz:
https://doaj.org/article/666e530cd3a04419b016f8e6f02df4ee
Publikováno v:
Trends in Biochemical Sciences. 47:745-758
The circadian clock is an intracellular timekeeping device that drives daily rhythms in diverse and extensive processes throughout the body. The clock mechanism comprises a core transcription/translation negative feedback loop that is modulated by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d7bcb23f7edc891bf026f894eb49c63
https://doi.org/10.1016/j.tibs.2022.04.009
https://doi.org/10.1016/j.tibs.2022.04.009
Publikováno v:
Biochemistry. 61:1091-1102
Endogenous circadian clocks control the rhythmicity of a broad range of behavioral and physiological processes, and this is entrained by the daily fluctuations in light and dark. Nocturnin (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e66246a7a14aa0bf0835b941976c63
https://doi.org/10.1021/acs.biochem.2c00072
https://doi.org/10.1021/acs.biochem.2c00072
Autor:
Lily Zhu, Naseem Maghzian, Carla B. Green, Aarati Pokharel, Camille T. Schrier, Jacob C. Deslauriers, Kevin He, John J. Tyson, Nobuya Koike, Allison N. Castaneda, Shihoko Kojima, Joseph S. Takahashi, Rebecca A. Mosig, Landon P. Frazier
Publikováno v:
Genes & Development. 35:899-913
In mammals, a set of core clock genes form transcription–translation feedback loops to generate circadian oscillations. We and others recently identified a novel transcript at the Period2 (Per2) locus that is transcribed from the antisense strand o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebfc6dfe5d523676b6227d16c8acac32
https://doi.org/10.1101/gad.343541.120
https://doi.org/10.1101/gad.343541.120