Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Carla A. Jaeger-Ruckstuhl"'
Autor:
Chris P. Miller, Megan Fung, Carla A. Jaeger-Ruckstuhl, Yuexin Xu, Edus H. Warren, Shreeram Akilesh, Scott S. Tykodi
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 46, Iss , Pp 100948- (2023)
Metastatic renal cell carcinoma (RCC) remains an incurable disease for most patients highlighting an urgent need for new treatments. However, the preclinical investigation of new therapies is limited by traditional two-dimensional (2D) cultures which
Externí odkaz:
https://doaj.org/article/9a6a0ba591d64c2b98c9db933ac8344f
Autor:
Carla A. Jaeger-Ruckstuhl, Magdalena Hinterbrandner, Sabine Höpner, Colin E. Correnti, Ursina Lüthi, Olivier Friedli, Stefan Freigang, Mohamad F. Al Sayed, Elias D. Bührer, Michael A. Amrein, Christian M. Schürch, Ramin Radpour, Carsten Riether, Adrian F. Ochsenbein
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Coordinate expression of multiple factors play critical roles in the regulation between effector and memory CD8+ T cell differentiation. Here the authors show upon acute viral infection TNIK is critically required as a regulator of effector and memor
Externí odkaz:
https://doaj.org/article/21c39ff478914e4584620912b78764da
Autor:
Brett K. Kaiser, Barry L. Stoddard, Betty W. Shen, Caley Ray Polkinghorn, Carla A. Jaeger-Ruckstuhl, Lindsey Doyle, Philip Bradley, Yuexin Xu, Colin Correnti, Jazmine P. Hallinan, Della Friend, Amanda Qu, Raymond O. Ruff, Ashok D. Bandaranayake, Stanley R. Riddell
Publikováno v:
Nat Struct Mol Biol
Protein engineering has enabled the design of molecular scaffolds that display a wide variety of sizes, shapes, symmetry and subunit composition. Symmetric protein-based nanoparticles that display multiple protein domains can exhibit enhanced functio
Autor:
Valentin Voillet, Carla A. Jaeger-Ruckstuhl, Stanley R. Riddell, Raphael Gottardo, Jennifer M. Specht, Smitha P. S. Pillai, Carolina Berger, Robert H. Pierce, Megha Sarvothama, Sarah M. Garrison, David G. Maloney, Scott N. Furlan, Sylvia Lee, Robert A. Amezquita, A. McGarry Houghton, Shivani Srivastava, Sushma Yechan-Gunja, Kimberly S. Smythe, Christoph Rader, Vishaka Muhunthan
Publikováno v:
Cancer cell. 39(2)
Summary Adoptive therapy using chimeric antigen receptor-modified T cells (CAR-T cells) is effective in hematologic but not epithelial malignancies, which cause the greatest mortality. In breast and lung cancer patients, CAR-T cells targeting the tum
Autor:
Carla A, Jaeger-Ruckstuhl, Magdalena, Hinterbrandner, Sabine, Höpner, Colin E, Correnti, Ursina, Lüthi, Olivier, Friedli, Stefan, Freigang, Mohamad F, Al Sayed, Elias D, Bührer, Michael A, Amrein, Christian M, Schürch, Ramin, Radpour, Carsten, Riether, Adrian F, Ochsenbein
Publikováno v:
Nature Communications
Co-stimulatory signals, cytokines and transcription factors regulate the balance between effector and memory cell differentiation during T cell activation. Here, we analyse the role of the TRAF2-/NCK-interacting kinase (TNIK), a signaling molecule do
Autor:
Stanley R Riddell, Ekram A Gad, Sylvain Simon, Tamer Basel Shabaneh, Andrew R Stevens, Sylvia M Stull, Kristen R Shimp, Brandon W Seaton, Carla A Jaeger-Ruckstuhl, Amanda L Koehne, Jason P Price, James M Olson, Benjamin G Hoffstrom, David Jellyman
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 2 (2024)
Background The paucity of tumor-specific targets for chimeric antigen receptor (CAR) T-cell therapy of solid tumors necessitates careful preclinical evaluation of the therapeutic window for candidate antigens. Human epidermal growth factor receptor 2
Externí odkaz:
https://doaj.org/article/eef8e83670544a3da80201117fcb7911