Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Carla, Nortje"'
The Use ofp-Aminobenzoic Acid as a Probe Substance for the Targeted Profiling of Glycine Conjugation
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 30:136-147
Glycine conjugation facilitates the metabolism of toxic aromatic acids, capable of disrupting mitochondrial integrity. Owing to the high exposure to toxic substrates, characterization of individual glycine conjugation capacity, and its regulatory fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f124e1cf066a9d568111abe1e3ae583c
https://doi.org/10.1002/jbt.21772
https://doi.org/10.1002/jbt.21772
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 31
Even though the glycine conjugation pathway was one of the first metabolic pathways to be discovered, this pathway remains very poorly characterized. The bi-substrate kinetic parameters of a recombinant human glycine N-acyltransferase (GLYAT, E.C. 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054a8da452737ce13d9cdb095dd55769
https://doi.org/10.1002/jbt.21963
https://doi.org/10.1002/jbt.21963
Publikováno v:
Journal of biochemical and molecular toxicology. 30(3)
Glycine conjugation facilitates the metabolism of toxic aromatic acids, capable of disrupting mitochondrial integrity. Owing to the high exposure to toxic substrates, characterization of individual glycine conjugation capacity, and its regulatory fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ec2a168e0a222cec87d49ec1e54b4b99
https://pubmed.ncbi.nlm.nih.gov/26484797
https://pubmed.ncbi.nlm.nih.gov/26484797
Publikováno v:
Bioanalysis. 7(10)
Background: p-Aminobenzoic acid (PABA) can be used as a probe substance to investigate glycine conjugation, a reaction of phase 2 biotransformation. Methodology/Results: An LC–MS/MS method for simultaneous quantification of PABA and its metabolites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736cf97df590d156f473c3bd516affa7
https://pubmed.ncbi.nlm.nih.gov/26045002
https://pubmed.ncbi.nlm.nih.gov/26045002
Autor:
Alberdina A. van Dijk, Christoffel P. S. Badenhorst, Elardus Erasmus, Rencia van der Sluis, Carla Nortje
A number of endogenous and xenobiotic organic acids are conjugated to glycine, in animals ranging from mosquitoes to humans. Glycine conjugation has generally been assumed to be a detoxification mechanism, increasing the water solubility of organic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6d3edc4b6f9f38667646b74cc679af4
https://hdl.handle.net/10394/15904
https://hdl.handle.net/10394/15904
Publikováno v:
AIDS Care. Feb2018, Vol. 30 Issue 2, p219-223. 5p. 6 Charts.
Publikováno v:
AIDS Care. Mar2017, Vol. 29 Issue 3, p280-284. 5p.
Publikováno v:
Drug Metabolism Reviews. Nov2015 Supplement, Vol. 47, p41-297. 257p.
Autor:
Badenhorst, Christoffel Petrus Stephanus1 (AUTHOR), Erasmus, Elardus1 (AUTHOR), van der Sluis, Rencia1 (AUTHOR), Nortje, Carla1 (AUTHOR), van Dijk, Alberdina Aike1 (AUTHOR) albie.vandijk@nwu.ac.za
Publikováno v:
Drug Metabolism Reviews. Aug2014, Vol. 46 Issue 3, p343-361. 19p.
Publikováno v:
AIDS & Behavior; Nov2017, Vol. 21 Issue 11, p3219-3227, 9p, 5 Charts