Pegylated Trastuzumab Fragments Acquire an Increased in Vivo Stability but Show a Largely Reduced Affinity for the Target Antigen

Autor: Giancarlo Tonon, Annamaria Sandomenico, Giuseppina Focà, Gloria Saccani Jotti, Silvia Scaramuzza, Fabio Selis, Concetta Di Mauro, Menotti Ruvo, Riccardo Sanna, Carla Marra, Annalisa Politano

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 17; Issue 4; Pages: 491
International Journal of Molecular Sciences, Vol 17, Iss 4, p 491 (2016)

PEGylation of biomolecules is a major approach to increase blood stream half-life, stability and solubility of biotherapeutics and to reduce their immunogenicity, aggregation potential and unspecific interactions with other proteins and tissues. Anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1317bb2ef884f661f8ec0f37a46e999
https://pubmed.ncbi.nlm.nih.gov/27043557

Failure of γ-hydroxybutyric acid both to increase neuroactive steroid concentrations in adrenalectomized–orchiectomized rats and to induce tolerance to its steroidogenic effect in intact animals

Autor: Cristina Ibba, Giovanni Biggio, Massimo Piredda, Alessandra Concas, Carla Marra, Robert H. Purdy, Cristiana Sogliano, Patrizia Porcu, Silvia Tocco

Publikováno v: Brain Research. 1012:160-168

γ-Hydroxybutyric acid (GHB), a drug proposed in the treatment of alcohol withdrawal syndrome, increases the cerebrocortical and plasma concentrations of the neuroactive steroids allopregnanolone and allotetrahydrodeoxycorticosterone (THDOC). In the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b372d20bd4c9157ac638f5ba7dd7676
https://doi.org/10.1016/j.brainres.2004.03.059

Neonatal exposure to estradiol in rats influences neuroactive steroid concentrations, GABAA receptor expression, and behavioral sensitivity to anxiolytic drugs

Autor: Carla Marra, Maria Cristina Mostallino, Maria Maddalena Angioni, A Calza, Alessandra Concas, F Santoru, Cristiana Sogliano, Giovanni Biggio

Publikováno v: Journal of neurochemistry. 113(5)

Gonadal steroids, in particular estradiol, exert important actions during pre- and perinatal periods in the regulation of sexual dimorphism and development of the nervous system. We have now examined the effects of neonatal estradiol administration i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f9bd5ada379b863bb4fde8df2af35f
https://pubmed.ncbi.nlm.nih.gov/20345753

Changes in GABA(A) receptor gene expression induced by withdrawal of, but not by long-term exposure to, ganaxolone in cultured rat cerebellar granule cells

Autor: Annalisa Manca, Francesca Biggio, Stefano Cabras, Carla Marra, Maria Paola Mascia, Paolo Follesa, Giorgio Gorini, Luisa Mancuso, Robert H. Purdy, Giovanni Biggio, Pier Luigi Cocco

Publikováno v: The Journal of pharmacology and experimental therapeutics. 303(3)

The effects of ganaxolone, a synthetic analog of the endogenous neuroactive steroid allopregnanolone, on the function and expression of GABA(A) receptors were determined. Electrophysiological recordings demonstrated that ganaxolone potentiated with a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c77f300097e9cd05984957f4170175
https://pubmed.ncbi.nlm.nih.gov/12438522