Zobrazeno 1 - 10
of 499
pro vyhledávání: '"Carl-Henrik Heldin"'
Autor:
Eleftheria Vasilaki, Yu Bai, Mohamad Moustafa Ali, Anders Sundqvist, Aristidis Moustakas, Carl-Henrik Heldin
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background p63 is a transcription factor with intrinsic pioneer factor activity and pleiotropic functions. Transforming growth factor β (TGFβ) signaling via activation and cooperative action of canonical, SMAD, and non-canonical, MAP-kinas
Externí odkaz:
https://doaj.org/article/c69b2398770746ad995d89ef0e1932d9
Autor:
Caroline Gélabert, Panagiotis Papoutsoglou, Irene Golán, Eric Ahlström, Adam Ameur, Carl-Henrik Heldin, Laia Caja, Aristidis Moustakas
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-26 (2023)
Abstract Background Long non-coding RNAs (lncRNAs) regulate cellular processes by interacting with RNAs or proteins. Transforming growth factor β (TGFβ) signaling via Smad proteins regulates gene networks that control diverse biological processes,
Externí odkaz:
https://doaj.org/article/a582c71957894d6caef289ea2cc1fa2b
Publikováno v:
BMC Molecular and Cell Biology, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background The platelet-derived growth factor (PDGF) family of ligands exerts their cellular effects by binding to α- and β-tyrosine kinase receptors (PDGFRα and PDGFRβ, respectively). SUMOylation is an important posttranslational modifi
Externí odkaz:
https://doaj.org/article/1ae0a1c24b224b0582c6b96dc03428a2
Autor:
Chrysoula Tsirigoti, Mohamad Moustafa Ali, Varun Maturi, Carl-Henrik Heldin, Aristidis Moustakas
Publikováno v:
Cell Death and Disease, Vol 13, Iss 9, Pp 1-17 (2022)
Abstract The transcription factor SNAI1 mediates epithelial-mesenchymal transition, fibroblast activation and controls inter-tissue migration. High SNAI1 expression characterizes metastatic triple-negative breast carcinomas, and its knockout by CRISP
Externí odkaz:
https://doaj.org/article/5913135f97914a38b7ebfdeeb90304c1
Autor:
Yutaro Tsubakihara, Yae Ohata, Yukari Okita, Shady Younis, Jens Eriksson, Mikael E. Sellin, Jiang Ren, Peter ten Dijke, Kohei Miyazono, Atsuhiko Hikita, Takeshi Imamura, Mitsuyasu Kato, Carl‐Henrik Heldin, Aristidis Moustakas
Publikováno v:
Molecular Oncology, Vol 16, Iss 12, Pp 2330-2354 (2022)
Transforming growth factor β (TGFβ) induces epithelial–mesenchymal transition (EMT), which correlates with stemness and invasiveness. Mesenchymal–epithelial transition (MET) is induced by TGFβ withdrawal and correlates with metastatic coloniza
Externí odkaz:
https://doaj.org/article/efbbbf26dd9f4806acc431c346def40f
Autor:
Ryo Tanabe, Kohei Miyazono, Tomoki Todo, Nobuhito Saito, Caname Iwata, Akiyoshi Komuro, Satoshi Sakai, Erna Raja, Daizo Koinuma, Masato Morikawa, Bengt Westermark, Carl‐Henrik Heldin
Publikováno v:
Molecular Oncology, Vol 16, Iss 1, Pp 269-288 (2022)
Glioma‐initiating cells (GICs), a major source of glioblastoma recurrence, are characterized by the expression of neural stem cell markers and the ability to grow by forming nonadherent spheres under serum‐free conditions. Bone morphogenetic prot
Externí odkaz:
https://doaj.org/article/f4c4a73f1b084baab8b336259bb1ce03
Autor:
Mahsa Shahidi Dadras, Laia Caja, Artur Mezheyeuski, Sijia Liu, Caroline Gélabert, Maria Catalina Gomez-Puerto, Radiosa Gallini, Carl-Johan Rubin, Peter ten Dijke, Carl-Henrik Heldin, Aristidis Moustakas
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-17 (2021)
Abstract Glioblastoma (GBM) is a brain malignancy characterized by invasiveness to the surrounding brain tissue and by stem-like cells, which propagate the tumor and may also regulate invasiveness. During brain development, polarity proteins, such as
Externí odkaz:
https://doaj.org/article/b71a0f01d1b640cf9b0950ad5952de50
Autor:
Dorival Mendes Rodrigues-Junior, Chrysoula Tsirigoti, Sai Kiang Lim, Carl-Henrik Heldin, Aristidis Moustakas
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Complexity in mechanisms that drive cancer development and progression is exemplified by the transforming growth factor β (TGF-β) signaling pathway, which suppresses early-stage hyperplasia, yet assists aggressive tumors to achieve metastasis. Of n
Externí odkaz:
https://doaj.org/article/a7241c1a9add4497b168bef0c6015ff2
Autor:
Chun-Yu Lin, Constantinos Kolliopoulos, Chung-Hao Huang, Jyrki Tenhunen, Carl-Henrik Heldin, Yen-Hsu Chen, Paraskevi Heldin
Publikováno v:
EBioMedicine, Vol 48, Iss , Pp 425-441 (2019)
Background: A main pathological feature of severe dengue virus infection is endothelial hyper-permeability. The dengue virus nonstructural protein 1 (NS1) has been implicated in the vascular leakage that characterizes severe dengue virus infection, h
Externí odkaz:
https://doaj.org/article/f5d9b1b571a946d2acf94249a0201325
Autor:
Noopur Thakur, Anahita Hamidi, Jie Song, Susumu Itoh, Anders Bergh, Carl-Henrik Heldin, Maréne Landström
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101470- (2020)
Summary: Transforming growth factor β (TGF-β) enhances migration and invasion of cancer cells, causing life-threatening metastasis. Smad7 expression is induced by TGF-β to control TGF-β signaling in a negative feedback manner. Here we report an a
Externí odkaz:
https://doaj.org/article/66dc3313eb444b5e9c5d9f570a4b9540