Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Carl-Friedrich Classen"'
Autor:
Charlotte Linke, Thomas Freitag, Christin Riess, Jana Vanessa Scheffler, Katharina del Moral, Nina Schoenwaelder, Tomas Fiedler, Adina Fiebig, Philipp Kaps, Daniel Dubinski, Björn Schneider, Wendy Bergmann, Carl Friedrich Classen, Claudia Maletzki
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-18 (2023)
Abstract Background Arginine auxotrophy constitutes a shortcoming for ~ 30% of glioblastoma multiforme (GBM). Indeed, arginine-depleting therapy using arginine deiminase from Streptococcus pyogenes (SpyADI) has proven activity against GBM in preclini
Externí odkaz:
https://doaj.org/article/b688d5f6f21b43c69fa8ffaf7d1c4143
Autor:
Christin Riess, Katharina del Moral, Adina Fiebig, Philipp Kaps, Charlotte Linke, Burkhard Hinz, Anne Rupprecht, Marcus Frank, Tomas Fiedler, Dirk Koczan, Sascha Troschke-Meurer, Holger N. Lode, Nadja Engel, Thomas Freitag, Carl Friedrich Classen, Claudia Maletzki
Publikováno v:
Cell Death and Disease, Vol 13, Iss 6, Pp 1-14 (2022)
The complex effects of combined CDki/SPyADI application on arginine-auxotrophic glioblastoma multiforme cells. CDki/SPyADI combination therapy impairs cell proliferation, invasiveness, gene expression, induces mitochondrial impairment, and vacuole fo
Externí odkaz:
https://doaj.org/article/e4a237d57e9d4704bd9c0f69a431ba27
Autor:
Georg Seifert, Sarah B. Blakeslee, Gabriele Calaminus, Farid I. Kandil, Andrea Barth, Toralf Bernig, Carl Friedrich Classen, Selim Corbacioglu, Jürgen Föll, Sven Gottschling, Bernd Gruhn, Claudia vom Hoff-Heise, Holger N. Lode, David Martin, Michaela Nathrath, Felix Neunhoeffer, Arnulf Pekrun, Beate Wulff, Tycho Zuzak, Günter Henze, Alfred Längler
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Integrative medicine is used frequently alongside chemotherapy treatment in pediatric oncology, but little is known about the influence on toxicity. This German, multi-center, open-label, randomized controlled trial assessed the e
Externí odkaz:
https://doaj.org/article/a1cf8077a3814e2ab28bcfe39c9641da
Autor:
Christin Riess, Dirk Koczan, Björn Schneider, Charlotte Linke, Katharina del Moral, Carl Friedrich Classen, Claudia Maletzki
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-15 (2021)
Abstract Current therapeutic approaches have met limited clinical success for glioblastoma multiforme (GBM). Since GBM harbors genomic alterations in cyclin-dependent kinases (CDKs), targeting these structures with specific inhibitors (CDKis) is prom
Externí odkaz:
https://doaj.org/article/68fa0d1afbb74b2487585beff34bf5af
Publikováno v:
Frontiers in Pediatrics, Vol 9 (2021)
In contrast to other lymphoid tissues making up the immune system, the spleen as its biggest organ is directly linked into the blood circulation. Beside its main task to filter out microorganism, proteins, and overaged or pathologically altered blood
Externí odkaz:
https://doaj.org/article/25e30ae8520042f7ab91065e622e8ffd
Autor:
Christin Riess, Björn Schneider, Hanna Kehnscherper, Julia Gesche, Nina Irmscher, Fatemeh Shokraie, Carl Friedrich Classen, Elisa Wirthgen, Grazyna Domanska, Annette Zimpfer, Daniel Strüder, Christian Junghanss, Claudia Maletzki
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO2) are the key enzymes of tryptophan (TRP) metabolism in the kynurenine pathway (KP). Both enzymes function as indicators of immunosuppression and poor survival in cancer patients.
Externí odkaz:
https://doaj.org/article/84a6ad70899d454bb54e3837a71f103e
Autor:
Christin Riess, Fatemeh Shokraie, Carl Friedrich Classen, Bernd Kreikemeyer, Tomas Fiedler, Christian Junghanss, Claudia Maletzki
Publikováno v:
Cellular Physiology and Biochemistry, Vol 51, Iss 2, Pp 854-870 (2018)
Arginine auxotrophy occurs in certain tumor types and is usually caused by the silencing of argininosuccinate synthetase 1 or arginine lyase genes. Such tumors are often associated with an intrinsic chemoresistance and thus a poor prognosis. Arginine
Externí odkaz:
https://doaj.org/article/07deca83d7ef459f8c6b4a08e663e55f
Autor:
Sarah Rehbein, Anna-Lena Possmayer, Süleyman Bozkurt, Catharina Lotsch, Julia Gerstmeier, Michael Burger, Stefan Momma, Claudia Maletzki, Carl-Friedrich Classen, Thomas M. Freiman, Daniel Dubinski, Katrin Lamszus, Bryan W. Day, Brett W. Stringer, Christel Herold-Mende, Christian Münch, Donat Kögel, Benedikt Linder
Glioblastoma is the most common primary brain cancer in adults and represents one of the worst cancer diagnosis for the patients. Suffering from a poor prognosis and limited treatment options, tumor recurrences are virtually inevitable. Additionally,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfd118ac43c6b6f1142c1dd4faf132f4
https://doi.org/10.1101/2023.05.16.540926
https://doi.org/10.1101/2023.05.16.540926
Autor:
Björn Schneider, Doreen William, Nora Lamp, Annette Zimpfer, Christian Henker, Carl Friedrich Classen, Andreas Erbersdobler
Publikováno v:
Molecular and Cellular Biochemistry. 477:2297-2307
Glioblastoma (GBM) is one of the most frequent primary brain tumors. Limited therapeutic options and high recurrency rates lead to a dismal prognosis. One frequent, putative driver mutation is the genomic amplification of the oncogenic receptor tyros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f908aaba8c06781a5978f1f68e1da04
https://doi.org/10.1007/s11010-022-04435-y
https://doi.org/10.1007/s11010-022-04435-y
Autor:
Carl Friedrich Classen
Publikováno v:
Kinder- und Jugendmedizin. 22:41-46
ZUSAMMENFASSUNGSeltene Histiozytosen, auch Non-Langerhans-Zell-Histiozytosen, sind alle proliferativen Erkrankungen der Histiozyten außer den Langerhans-Zell-Histiozytosen (LCH) und Hämophagozytischen Lymphohistiozytosen (HLH): benigne oder maligne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e6de08f8427dd7090949ab0a9fe0edc
https://doi.org/10.1055/a-1677-7487
https://doi.org/10.1055/a-1677-7487