Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Carl de Luca"'
Autor:
Young Hwan Jo, Qiu Xia, Daniel J. Spergel, Siok L. Dun, Streamson C. Chua, Sharone Sheffer-Babila, Carl de Luca, Davelene D. Israel, Nae J. Dun, Shun Mei Liu
Publikováno v:
Endocrinology. 153:2408-2419
Leptin and melanocortin signaling control ingestive behavior, energy balance, and substrate utilization, but only leptin signaling defects cause hypothalamic hypogonadism and infertility. Although GnRH neurons do not express leptin receptors, leptin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6506d76bf94f0f18183a5fb7f40b0826
https://doi.org/10.1210/en.2011-1822
https://doi.org/10.1210/en.2011-1822
Autor:
Jerrold M. Olefsky, Gautam Bandyopadhyay, Simon Schenk, Maziyar Saberi, Niels-Bjarne Woods, Inder M. Verma, Carl de Luca, Juu Chin Lu
Publikováno v:
Cell Metabolism. 10(5):419-429
Chronic, low-grade inflammation, particularly in adipose tissue, is an important modulator of obesity-induced insulin resistance and the toll-like receptor 4 (Tlr4) is a key initiator of inflammatory responses in macrophages. We performed bone marrow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8275e432462dec558ccaffbd58e679
Autor:
Young Hwan Jo, Joel K. Elmquist, Martin G. Myers, Gary J. Schwartz, Carl de Luca, David B. Allison, Esther H.E.M. van de Wall, Roberto Coppari, Nae J. Dun, Shun Mei Liu, Bradford B. Lowell, Rebecca L. Leshan, Robert G. MacKenzie, Streamson C. Chua, Gregory S. Barsh, Nina Balthasar, Allison W. Xu
Publikováno v:
Endocrinology. 149:1773-1785
Two known types of leptin-responsive neurons reside within the arcuate nucleus: the agouti gene-related peptide (AgRP)/neuropeptide Y (NPY) neuron and the proopiomelanocortin (POMC) neuron. By deleting the leptin receptor gene (Lepr) specifically in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f825c61cec21773119f76956983e58f3
https://doi.org/10.1210/en.2007-1132
https://doi.org/10.1210/en.2007-1132
Autor:
Sara B. Seidelmann, Carl De Luca, Rudolph L. Leibel, Jan L. Breslow, Carrie L. Welch, Alan R. Tall
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 25:204-210
Objective— The purpose of this study was to examine genetic factors responsible for metabolic syndrome and atherosclerosis in a setting of low-density lipoprotein (LDL) receptor deficiency in a cross between C57BL/6J (B6) and PERA/Ei (PERA) inbred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8fa3f4c4d4c29348d26fbd14fdbb59
https://doi.org/10.1161/01.atv.0000149146.32385.1b
https://doi.org/10.1161/01.atv.0000149146.32385.1b
Autor:
Carl de Luca, Jerrold M. Olefsky
Obesity-induced chronic inflammation is a key component in the pathogenesis of insulin resistance and the Metabolic syndrome. In this review, we focus on the interconnection between obesity, inflammation and insulin resistance. Pro-inflammatory cytok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18264a23f64d3fc26ad8b02c861cdb24
https://europepmc.org/articles/PMC2246086/
https://europepmc.org/articles/PMC2246086/
Autor:
Carey N. Lumeng, Sarah E. Hosch, Mohammad Pashmforoush, Jaap G. Neels, Lisa A. Lesniewski, Miriam Scadeng, Carl de Luca, Alan R. Saltiel, Jerrold M. Olefsky, Shian Huey Chiang
Publikováno v:
Nature medicine. 13(4)
Cbl-associated protein (Cap) is a member of a phosphatidylinositol 3-kinase-independent pathway for insulin-stimulated translocation of the glucose transporter GLUT4. Despite this positive role of Cap in glucose uptake, here we show that deletion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c579f7d0495648a5fd4bc06458f63b51
https://pubmed.ncbi.nlm.nih.gov/17351624
https://pubmed.ncbi.nlm.nih.gov/17351624
Autor:
Streamson C. Chua, Charlotte E. Lee, Yiying Zhang, Manfred W. Kilimann, Carl de Luca, Timothy J. Kowalski, Thomas Ludwig, Shun Mei Liu, Joel K. Elmquist
Publikováno v:
The Journal of clinical investigation. 115(12)
We have generated mice that carry a neuron-specific leptin receptor (LEPR) transgene whose expression is driven by the rat synapsin I promoter synapsin-LEPR B (SYN-LEPR-B). We have also generated mice that are compound hemizygotes for the transgenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb54f2356dbdf970fa0924ed76c21123
https://pubmed.ncbi.nlm.nih.gov/16284652
https://pubmed.ncbi.nlm.nih.gov/16284652
Autor:
Jerrold M. Olefsky, Carl de Luca
Publikováno v:
Nature Medicine. 12:41-42
Obesity-related chronic inflammation underlies insulin resistance, a key feature of type 2 diabetes. Recent data link the stress pathway of the endoplasmic reticulum to this phenomenon.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e07c211ef4b8265438832feb39b23072
https://doi.org/10.1038/nm0106-41
https://doi.org/10.1038/nm0106-41