Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Carl Wu"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Autonomous mobile clinics (AMCs) have the potential to revolutionize healthcare delivery by bringing healthcare services to patients at the order of patient’s fingertips. Particularly, AMCs can act as an essential touch point of integrated
Externí odkaz:
https://doaj.org/article/430bad1fb4dc41d0aeb45597caaefd55
Publikováno v:
eLife, Vol 13 (2024)
The organization of nucleosomes into chromatin and their accessibility are shaped by local DNA mechanics. Conversely, nucleosome positions shape genetic variations, which may originate from mismatches during replication and chemical modification of D
Externí odkaz:
https://doaj.org/article/13849300e9cf4a028110792ce05041f9
Autor:
Jee Min Kim, Claudia C Carcamo, Sina Jazani, Zepei Xie, Xinyu A Feng, Maryam Yamadi, Matthew Poyton, Katie L Holland, Jonathan B Grimm, Luke D Lavis, Taekjip Ha, Carl Wu
Publikováno v:
eLife, Vol 12 (2024)
Eukaryotic gene expression is linked to chromatin structure and nucleosome positioning by ATP-dependent chromatin remodelers that establish and maintain nucleosome-depleted regions (NDRs) near transcription start sites. Conserved yeast RSC and ISW2 r
Externí odkaz:
https://doaj.org/article/4cf8e8e01a1d4b77bf1f4aab8ec938ef
Autor:
Claudia C Carcamo, Matthew F Poyton, Anand Ranjan, Giho Park, Robert K Louder, Xinyu A Feng, Jee Min Kim, Thuc Dzu, Carl Wu, Taekjip Ha
Publikováno v:
eLife, Vol 11 (2022)
One-dimensional (1D) target search is a well-characterized phenomenon for many DNA-binding proteins but is poorly understood for chromatin remodelers. Herein, we characterize the 1D scanning properties of SWR1, a conserved yeast chromatin remodeler t
Externí odkaz:
https://doaj.org/article/6aa0b8a428a042de8a34d93545e86580
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Chromosome segregation requires the association of the kinetochore protein complex with a specialized nucleosome at the centromere. Here, the authors present cryo-EM and mutational studies that provide insights into the structure of the budding yeast
Externí odkaz:
https://doaj.org/article/763685637eb344f2b203a00440b62909
Autor:
Jee Min Kim, Pat Visanpattanasin, Vivian Jou, Sheng Liu, Xiaona Tang, Qinsi Zheng, Kai Yu Li, Jonathan Snedeker, Luke D Lavis, Timothee Lionnet, Carl Wu
Publikováno v:
eLife, Vol 10 (2021)
Conserved ATP-dependent chromatin remodelers establish and maintain genome-wide chromatin architectures of regulatory DNA during cellular lifespan, but the temporal interactions between remodelers and chromatin targets have been obscure. We performed
Externí odkaz:
https://doaj.org/article/8fb2885b44e143138060e873562959e7
Autor:
Qinsi Zheng, Anthony X. Ayala, Inhee Chung, Aubrey V. Weigel, Anand Ranjan, Natalie Falco, Jonathan B. Grimm, Ariana N. Tkachuk, Carl Wu, Jennifer Lippincott-Schwartz, Robert H. Singer, Luke D. Lavis
Publikováno v:
ACS Central Science, Vol 5, Iss 9, Pp 1602-1613 (2019)
Externí odkaz:
https://doaj.org/article/858eaf0125214e269b4875dfab2ab8b4
Autor:
Anand Ranjan, Vu Q Nguyen, Sheng Liu, Jan Wisniewski, Jee Min Kim, Xiaona Tang, Gaku Mizuguchi, Ejlal Elalaoui, Timothy J Nickels, Vivian Jou, Brian P English, Qinsi Zheng, Ed Luk, Luke D Lavis, Timothee Lionnet, Carl Wu
Publikováno v:
eLife, Vol 9 (2020)
The H2A.Z histone variant, a genome-wide hallmark of permissive chromatin, is enriched near transcription start sites in all eukaryotes. H2A.Z is deposited by the SWR1 chromatin remodeler and evicted by unclear mechanisms. We tracked H2A.Z in living
Externí odkaz:
https://doaj.org/article/68623bc3e237447ba32f6afbac61397c
Autor:
Yunyun Wang, Sheng Liu, Lu Sun, Ning Xu, Shan Shan, Fei Wu, Xiaoping Liang, Yingzi Huang, Ed Luk, Carl Wu, Zheng Zhou
Publikováno v:
PLoS Biology, Vol 17, Iss 5, p e3000277 (2019)
Chz1 is a specific chaperone for the histone variant H2A.Z in budding yeast. The ternary complex formed by Chz1 and H2A.Z-H2B dimer is the major in vivo substrate of Swi2/snif2-related 1 (SWR1), the ATP-dependent chromatin remodeling enzyme that depo
Externí odkaz:
https://doaj.org/article/780f576cbb504151931557443b0a3d36
Autor:
Qinsi Zheng, Anthony X. Ayala, Inhee Chung, Aubrey V. Weigel, Anand Ranjan, Natalie Falco, Jonathan B. Grimm, Ariana N. Tkachuk, Carl Wu, Jennifer Lippincott-Schwartz, Robert H. Singer, Luke D. Lavis
Publikováno v:
ACS Central Science, Vol 6, Iss 10, Pp 1844-1844 (2020)
Externí odkaz:
https://doaj.org/article/a02452f5f0f949fdabac3f315b5a2ce5