Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Carl W. Sigel"'
Autor:
Deborah A. Winegar, Carl W. Sigel, James Chapman, Jo A. Salisbury, Roy L. Hawke, Alan Robert Brown, Richard M. Welch, Karl Witold Franzmann
Publikováno v:
Journal of Lipid Research, Vol 38, Iss 6, Pp 1189-1203 (1997)
The hypocholesterolemic activity for novel ureido fibrate analogues was found to be over 100-fold greater than for any “second-generation” fibrate in cholesterol-fed rats. A comparison of 12 related analogues revealed that the optimal configurati
Publikováno v:
Biochemical Pharmacology. 42:337-346
Metabolism of the anticancer agent crisnatol was investigated using a human hepatoma cell line, Hep G2, and human liver microsomes. Crisnatol was metabolized extensively by both systems. The TLC/autoradiographic analysis showed that the crisnatol met
Publikováno v:
Therapeutic Drug Monitoring. 12:382-392
Procedures for the simultaneous determination of trimethoprim (TMP) and sulfamethoxazole (SMX) in plasma or urine are reported. The drugs are extracted from plasma or urine by a single solid-phase extraction and quantitated by high-performance liquid
Autor:
Walter L. Meyer, Richard A. Manning, R. John Hoff, Carl W. Sigel, Thomas E. Goodwin, Patricia G. Schroeder
Publikováno v:
The Journal of Organic Chemistry. 42:4131-4136
Publikováno v:
Journal of Liquid Chromatography. 3:1843-1852
The rapid microcomputer processing of quantitative TLC scanning data is described. The microcomputer, using BASIC language, is based on the Intel 8080A microprocessor IC and has 64K bytes of RAM. Data is acquired via a 16-bit integrating ADC. A TLC p
Publikováno v:
Journal of Liquid Chromatography. 3:1835-1842
The technique of cross-scanning, the scanning of thin-layer chromatographic (TLC) plates perpendicular to the direction of development, is applicable to conventional quantitative TLC where significant advantages over normal scanning are realized by i
Autor:
George E. Templeton, Walter L. Meyer, Lee F. Kuyper, Carl I. Grable, R. Burton Lewis, Carl W. Sigel, Suzan H. Woodhead, Ronald L. Jones
Publikováno v:
Journal of the American Chemical Society. 97:3802-3809
Publikováno v:
Journal of Liquid Chromatography. 3:833-839
The use of non-polar solvents for sample application in quantitative thin-layer chromatography (TLC) was shown to have a marked effect on the precision of the analytical technique when polar compounds were applied to silica gel plates. Increasing the
Publikováno v:
Journal of the American Chemical Society. 98:2295-2300
Publikováno v:
Journal of Infectious Diseases. 128:S580-S583
Urinary concentrations of trimethoprim (TMP) and its metabolites were measured in eight healthy subjects after oral administration of 160 mg of TMP in two tablets of Septra@ (trimethoprim-sulfamethoxazole). Improved procedures for extraction of polar