Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Carl W. Schmid"'
Publikováno v:
Cladistics : the international journal of the Willi Hennig SocietyREFERENCES. 5(1)
— This article evaluates the use of DNA hybridization for estimating the extent of divergence among the single-copy fractions of vertebrate genomes. It focuses, in particular, on the nature and informational content of the melting profiles as a gui
Publikováno v:
Gene. 276:127-133
During heat shock recovery in Hela cells, the level of Alu RNA transiently increases with kinetics that approximately parallel the transient expression of heat shock protein mRNAs. Coincidentally, there is a transient increase in the accessibility of
Publikováno v:
Molecular Human Reproduction. 7:903-911
Genes or multigenic chromosomal regions are organized by the nuclear matrix into a series of functionally discrete genic domains. Biophysical analysis of the human chromosome 16p13.13 region has shown that the PRM1--PRM2--TNP2 protamine containing mu
Publikováno v:
Gene. 239:367-372
The possible functionality of short interspersed elements (SINEs) is investigated by assaying the effects of physiological stress on their RNA polymerase-III-directed transcriptional expression in vivo. B2 RNA is expressed at moderately high levels i
Publikováno v:
Nucleic Acids Research. 27:3380-3387
The effect of cell stresses upon the expression of the Bm1 short interspersed element (SINE) family in cultured silk worm cells is examined. Primer extension analysis shows that Bm1 repeats are transcribed by RNA polymerase III (Pol III) into cytopla
Autor:
Carl W. Schmid
Publikováno v:
Nucleic Acids Research. 26:4541-4550
The evolution, mobility and deleterious genetic effects of human Alus are fairly well understood. The complexity of regulated transcriptional expression of Alus is becoming apparent and insight into the mechanism of retrotransposition is emerging. Un
Publikováno v:
Journal of Biological Chemistry. 272:14755-14761
The retinoblastoma susceptibility gene product (Rb) generally represses RNA polymerase III (Pol III)-directed transcription. This implies that Rb interacts with essential transcription factors. Mutations in either the A or B subdomains in the Rb pock
Autor:
Carl W. Schmid, Igor Chesnokov
Publikováno v:
Journal of Molecular Evolution. 42:30-36
An Alu source gene, called the EPL Alu, was previously isolated by a phylogenetic strategy. Sequences flanking the EPL Alu family member stimulate its RNA polymerase III (Pol III) template activity in vitro. One cis-acting element maps within a 40-nu
Autor:
Carl W. Schmid, Jerzy Jurka, Damian Labuda, Prescott L. Deininger, Carol M. Rubin, Utha Hellmann-Blumberg, Ewa Ziętkiewicz, Mark A. Batzer, Emile Zuckerkandl
Publikováno v:
Journal of Molecular Evolution. 42:3-6
1 Human Genome Center, L-452, Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94551, USA 2 Department of Biochemistry and Molecular Biology, Center for Human and Molecular Genetics, Loui
Publikováno v:
Cancer Letters. 97:163-168
Freshly resected human non-small cell lung cancer (NSCLC) has been successfully transplanted and propagated subcutaneously in nude mice (Cancer Letters 61 (1991) 53-60). We used this model to study the changes of the human metastasis suppressor genes