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of 34
pro vyhledávání: '"Carl T. Wild"'
A single G10T polymorphism in HIV-1 subtype C Gag-SP1 regulates sensitivity to maturation inhibitors
Publikováno v:
Retrovirology, Vol 18, Iss 1, Pp 1-18 (2021)
Abstract Background Maturation inhibitors (MIs) potently block HIV-1 maturation by inhibiting the cleavage of the capsid protein and spacer peptide 1 (CA-SP1). Bevirimat (BVM), a highly efficacious first-in-class MI against HIV-1 subtype B isolates,
Externí odkaz:
https://doaj.org/article/5f37a1ea91794a46bbc06c01e2763d89
A single G10T polymorphism in HIV-1 subtype C Gag-SP1 regulates sensitivity to maturation inhibitors
Autor:
Uddhav Timilsina, Theodore J. Nitz, Carl T. Wild, Dibya Ghimire, Kriti Goel, Yuvraj Kc, Ritu Gaur
Publikováno v:
Retrovirology, Vol 18, Iss 1, Pp 1-18 (2021)
Retrovirology
Retrovirology
Background Maturation inhibitors (MIs) potently block HIV-1 maturation by inhibiting the cleavage of the capsid protein and spacer peptide 1 (CA-SP1). Bevirimat (BVM), a highly efficacious first-in-class MI against HIV-1 subtype B isolates, elicited
Autor:
Cheryl A Stoddart, Pheroze Joshi, Barbara Sloan, Jennifer C Bare, Philip C Smith, Graham P Allaway, Carl T Wild, David E Martin
Publikováno v:
PLoS ONE, Vol 2, Iss 11, p e1251 (2007)
The HIV-1 maturation inhibitor, 3-O-(3',3'-dimethylsuccinyl) betulinic acid (bevirimat, PA-457) is a promising drug candidate with 10 nM in vitro antiviral activity against multiple wild-type (WT) and drug-resistant HIV-1 isolates. Bevirimat has a no
Externí odkaz:
https://doaj.org/article/767cee83f8bd4f77a00802dac5c2710b
Autor:
Justin A. Kaplan, Phuong Pham, Nishani D. Kuruppu, Dibya Ghimire, Rebecca Mandt, Ritu Gaur, Emiko Urano, David E. Martin, Stewart R. Durell, Eric O. Freed, Uddhav Timilsina, Carl T. Wild, Theodore J. Nitz, Sherimay D. Ablan
A betulinic acid-based compound, bevirimat (BVM), inhibits HIV-1 maturation by blocking a late step in protease-mediated Gag processing: the cleavage of the capsid-spacer peptide 1 (CA-SP1) intermediate to mature CA. Previous studies showed that muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9289a8403101529731b5e8f7cf355e04
https://europepmc.org/articles/PMC6401422/
https://europepmc.org/articles/PMC6401422/
Autor:
Gary T. Pauly, Dina M. Sigano, Emiko Urano, Carl T. Wild, Joel P. Schneider, Rebecca Mandt, Theodore J. Nitz, Sherimay D. Ablan, David E. Martin, Eric O. Freed
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:190-197
Concomitant with the release of human immunodeficiency virus type 1 (HIV-1) particles from the infected cell, the viral protease cleaves the Gag polyprotein precursor at a number of sites to trigger virus maturation. We previously reported that a bet
Autor:
Uddhav Timilsina, Theodore J. Nitz, Eric O. Freed, Ritu Gaur, Dibya Ghimire, Bivek Timalsina, Carl T. Wild
Publikováno v:
Scientific Reports
Antiretroviral therapy has led to a profound improvement in the clinical care of HIV-infected patients. However, drug tolerability and the evolution of drug resistance have limited treatment options for many patients. Maturation inhibitors are a new
Autor:
Feng Li, Eric O. Freed, Suvobrata Chakravarty, Dan Wang, Wuxun Lu, Karl Salzwedel, Carl T. Wild
Publikováno v:
Antimicrobial Agents and Chemotherapy. 55:3324-3329
3- O -(3′,3′-Dimethylsuccinyl) betulinic acid (DSB), also known as PA-457, bevirimat (BVM), or MPC-4326, is a novel HIV-1 maturation inhibitor. Unlike protease inhibitors, BVM blocks the cleavage of the Gag capsid precursor (CA-SP1) to mature cap
Elevated temperature triggers human respiratory syncytial virus F protein six-helix bundle formation
Autor:
Katherine Crisafi, Abdul S. Yunus, Karl Salzwedel, Nicole Kilgore, Dorian Zoumplis, Carl T. Wild, Trent P. Jackson, Graham P. Allaway, Irina Burimski
Publikováno v:
Virology
Human respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infection in infants, immunocompromised patients, and the elderly. The RSV fusion (F) protein mediates fusion of the viral envelope with the target cell membra
Autor:
Karl Salzwedel, Eric O. Freed, Dorian Zoumplis, Feng Li, Catherine S. Adamson, Abdul S. Yunus, Claudia Matallana, Nicole Kilgore, David E. Martin, Mary Reddick, Graham P. Allaway, Carl T. Wild
Publikováno v:
Virology. 356(1-2):217-224
3-O-(3′,3′-dimethylsuccinyl) betulinic acid, also termed PA-457 or DSB, is a novel HIV-1 inhibitor that blocks virus maturation by disrupting cleavage of the capsid precursor, CA-SP1. To better define the molecular target for PA-457, we prepared
Autor:
Chin Ho Chen, Graham P. Allaway, Carl T. Wild, Donglei Yu, Susan L. Morris-Natschke, David E. Martin, Kuo Hsiung Lee
Publikováno v:
Expert Opinion on Investigational Drugs. 14:681-693
Although HIV infection is now primarily treated with reverse transcriptase and protease inhibitors, HIV therapy must look toward new drugs with novel mechanism(s) of action to both improve efficacy and address the growing problem of drug resistance.