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Caudate Glucose Metabolic Rate Changes With Both Drug and Behavior Therapy for Obsessive-Compulsive Disorder

Autor: Jeffrey M. Schwartz, Michael E. Phelps, Paul Munford, Carl Selin, Kenneth S. Bergman, Martin P. Szuba, Lewis R. Baxter, Adina Alazraki, Barry H. Guze, John C. Mazziotta, Huan-Kwang Ferng

Publikováno v: Archives of General Psychiatry. 49:681

• We used positron emission tomography to investigate local cerebral metabolic rates for glucose (LCMRG1c) in patients with obsessive-compulsive disorder before and after treatment with either fluoxetine hydrochloride or behavior therapy. After tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40657438e80335e06a853f52c3c5687
https://doi.org/10.1001/archpsyc.1992.01820090009002

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Psychiatric, Genetic, and Positron Emission Tomographic Evaluation of Persons at Risk for Huntington's Disease

Autor: Peter St George-Hyslop, James F. Gusella, Martin P. Szuba, Michael E. Phelps, Jonathan L. Haines, John C. Mazziotta, Scott T. Grafton, Barry H. Guze, Carl Selin, Lewis R. Baxter, Jorg J. Pahl

Publikováno v: Archives of General Psychiatry. 49:148

• We examined chorea-free subjects at risk for Huntington's disease (n = 52) for lifetime psychiatric diagnoses, present mood, genetic marker status, and caudate glucose metabolic rates with positron emission tomography. Based on previous work, a c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b2cd8cfdeba5d39b4d535be702475ae
https://doi.org/10.1001/archpsyc.1992.01820020068009

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Trazodone Treatment Response in Obsessive-Compulsive Disorder – Correlated with Shifts in Glucose Metabolism in the Caudate Nuclei

Autor: Lewis R. Baxter, Jeff Schwartz, Carl Selin, J.M. Thompson, L. Moss, John C. Mazziotta, Barry H. Guze, Michael E. Phelps

Publikováno v: Psychopathology. 20:114-122

Obsessive-compulsive disorder (OCD) is a severe psychiatric illness that is difficult to treat. The effects of trazodone hydrochloride treatment were studied, both with and without the addition of a monoamine oxidase inhibitor, in OCD patients. Chang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::631767af7aca8eee1c5cbc6a4976a5ce
https://doi.org/10.1159/000284530

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Epileptic patterns of local cerebral metabolism and perfusion in humans determined by emission computed tomography of18FDG and13NH3

Autor: Michael E. Phelps, Carl Selin, Jerome Engel, David E. Kuhl

Publikováno v: Annals of Neurology. 8:348-360

Seventeen patients with partial epilepsy had electroencephalographic (EEG) monitoring concurrent with cerebral positron emission computed tomography (PECT) after 18F-fluorodeoxyglucose (18FDG) and 13N-ammonia (13NH3) were given intravenously as indic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e930a107e050d36cc3841d1b3d5980b
https://doi.org/10.1002/ana.410080403

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Effects of inhibition of fatty acid oxidation on myocardial kinetics of 11C-labeled palmitate

Autor: Sung-Cheng Huang, Heinrich R. Schelbert, Carl Selin, William Wyns, Randy E. Keen, Denis B. Buxton, Markus Schwaiger, Herbert Hansen, Michael E. Phelps

Publikováno v: Scopus-Elsevier

The effects of glucose and lactate infusion on palmitate oxidation were compared with the effect of 2-tetradecylglycidic acid (TDGA), an irreversible inhibitor of the carnitine acyltransferase I, in normoxic canine myocardium. The initial capillary t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14df0d5ff41e913366b36d9019568e65
https://doi.org/10.1161/01.res.65.6.1787

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Relationship between TI-201, Tc-99m (Sn) pyrophosphate and F-18 2-deoxyglucose uptake in ischemically injured dog myocardium

Autor: Michael E. Phelps, Herbert Hansen, Heinrich R. Schelbert, Oberdan Parodi, Carl Selin, Sung-Cheng Huang, Heinz Sochor, Markus Schwaiger, Douglas Ellison

Publikováno v: American Heart Journal. 114:1066-1077

We have previously demonstrated that enhanced glucose utilization in reperfused myocardium as assessed by F-18 2-deoxyglucose (FDG) and positron tomography predicts functional recovery. In this study, we compared segmental uptake of F-18 FDG with tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1325ad928a09f10dd5008819e97981d3
https://doi.org/10.1016/0002-8703(87)90181-5

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Metabolic and ultrastructural abnormalities during ischemia in canine myocardium: Noninvasive assessment by positron emission tomography

Autor: Michael E. Phelps, Carl Selin, William Wijns, Mark I. Block, Herbert Hansen, Michael C. Fishbein, Heinrich R. Schelbert, Markus Schwaiger

Publikováno v: Journal of Molecular and Cellular Cardiology. 19:259-269

Positron emission tomography allows the noninvasive assessment of regional myocardial blood flow and metabolism. The purpose of this study was to correlate N-13 ammonia uptake as a measure of regional blood flow and C-11 palmitate kinetics as a marke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2036c522a9a4d40486fc48e29bf928
https://doi.org/10.1016/s0022-2828(87)80593-x

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Cardiac Emission Computed Tomography

Autor: Edward J. Hoffman, Heinrich R. Schelbert, Oberdan Parodi, Markus Schwaiger, Herbert Hansen, Carl Selin

Publikováno v: Scopus-Elsevier

Possible effects of regional wall motion abnormalities on apparent regional myocardial tracer concentrations on emission tomographic images were evaluated in six open chest dogs. Each dog was studied twice: In Run 1, 13N ammonia and microspheres were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba4d5f8074cfd6c5fddad820f5147b3
https://doi.org/10.1097/00004728-198412000-00008

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