Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Carl S. Crysler"'
Autor:
Ehab Khalil, Anna C. Maroney, Kevin J. Moriarty, Farah Ali, Robert A. Galemmo, Dana L. Johnson, Carl S. Crysler, Holly K. Koblish, Ioanna P. Petrounia, Thomas Garrabrant, Jahanvi Maisuria
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5778-5783
A new class of Aurora-A inhibitors have been identified based on the 2-amino-pyrrolo[2,3-d]pyrimidine scaffold. Here, we describe the synthesis and SAR of this novel series. We report compounds which exhibit nanomolar activity in the Aurora-A biochem
Autor:
Carl R, Illig, Carl L, Manthey, Mark J, Wall, Sanath K, Meegalla, Jinsheng, Chen, Kenneth J, Wilson, Shelley K, Ballentine, Renee L, Desjarlais, Carsten, Schubert, Carl S, Crysler, Yanmin, Chen, Christopher J, Molloy, Margery A, Chaikin, Robert R, Donatelli, Edward, Yurkow, Zhao, Zhou, Mark R, Player, Bruce E, Tomczuk
Publikováno v:
Journal of medicinal chemistry. 54(22)
A class of potent inhibitors of colony-stimulating factor-1 receptor (CSF-1R or FMS), as exemplified by 8 and 21, was optimized to improve pharmacokinetic and pharmacodynamic properties and potential toxicological liabilities. Early stage absorption,
Autor:
Tianbao Lu, Thomas Markotan, Shelley K. Ballentine, Edward C. Giardino, John Spurlino, Carl S. Crysler, Kathryn Brown, Bruce E. Maryanoff, Bruce E. Tomczuk, Bruce P. Damiano, Umesh Shukla, David End, Patricia Andrade-Gordon, Roger F. Bone, Mark R. Player
Publikováno v:
Journal of Medicinal Chemistry. 53:3422-3422
Autor:
Carl R. Illig, Carl L. Manthey, Mark J. Wall, Sanath K. Meegalla, Jinsheng Chen, Kenneth J. Wilson, Shelley K. Ballentine, ReneeL. DesJarlais, Carsten Schubert, Carl S. Crysler, Yanmin Chen, Christopher J. Molloy, Margery A. Chaikin, Robert R. Donatelli, Edward Yurkow, Zhao Zhou, Mark R. Player, Bruce E. Tomczuk
Publikováno v:
Journal of Medicinal Chemistry; Nov2011, Vol. 54 Issue 22, p7860-7883, 24p
Autor:
Hui Huang, Daniel A. Hutta, James M. Rinker, Huaping Hu, William H. Parsons, Carsten Schubert, Renee L. DesJarlais, Carl S. Crysler, Margery A. Chaikin, Robert R. Donatelli, Yanmin Chen, Deping Cheng, Zhao Zhou, Edward Yurkow, Carl L. Manthey, Mark R. Player
Publikováno v:
Journal of Medicinal Chemistry; Feb2009, Vol. 52 Issue 4, p1081-1099, 19p
Autor:
Yu-Kai Lee, Daniel J. Parks, Tianbao Lu, Tho V. Thieu, Thomas Markotan, Wenxi Pan, David F. McComsey, Karen L. Milkiewicz, Carl S. Crysler, Nisha Ninan, Marta C. Abad, Edward C. Giardino, Bruce E. Maryanoff, Bruce P. Damiano, Mark R. Player
Publikováno v:
Journal of Medicinal Chemistry; Dec2007, Vol. 51 Issue 2, p282-297, 16p
Autor:
G A Kopia, Linda J. Kopaciewicz, Robert R. Ruffolo, Kei-Lai L. Fong, Kathleen Boyle, Carl S. Crysler
Publikováno v:
Journal of Cardiovascular Pharmacology. 12:308-316
The thrombolytic dose-response effectiveness and pharmacokinetics of tissue-type plasminogen activator (rt-PA) was evaluated in anesthetized, open-chest dogs instrumented for the measurement of systemic hemodynamics. Intracoronary thrombi were formed