Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Carl Rosenblad"'
Publikováno v:
Neurobiology of Disease, Vol 4, Iss 3, Pp 186-200 (1997)
Intrastriatal 6-hydroxydopamine injections in rats induce partial lesions of the nigrostriatal dopamine (DA) system which are accompanied by a delayed and protracted degeneration of DA neurons within the substantia nigra. By careful selection of the
Externí odkaz:
https://doaj.org/article/da245300d957474db038a238044788f5
Autor:
Leticia Agúndez, Sandra Dovero, Anders Björklund, Carl Rosenblad, André S L M Antunes, Elsa Y. Pioli, Els Henckaerts, R. Michael Linden, Qin Li, Tomas Björklund, Martino Bardelli, Erwan Bezard
Publikováno v:
Brain
Heterozygous variants in SOD1 are a major cause of familial amyotrophic lateral sclerosis. Park et al. report the first known case of SOD1 deficiency, a disorder distinct from ALS characterized by mild cerebellar atrophy and hyperekplexia-like sympto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037399c19664928564ceccf5262a5294
https://doi.org/10.1093/brain/awz176
https://doi.org/10.1093/brain/awz176
Autor:
Bengt Juliusson, Nicolaj S. Christophersen, Patrik Brundin, Nikolaj Blom, Mette Grønborg, Jesper Roland Jørgensen, Lone Fjord-Larsen, Thomas Nordahl Petersen, Carl Rosenblad
Publikováno v:
Experimental Neurology. 204:791-801
Affymetrix GeneChip technology and quantitative real-time PCR (Q-PCR) were used to examine changes in gene expression in the adult murine substantia nigra pars compacta (SNc) following lentiviral glial cell line-derived neurotrophic factor (GDNF) del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4b6f29df5ab6877f6abda0e9614247c
https://doi.org/10.1016/j.expneurol.2007.01.014
https://doi.org/10.1016/j.expneurol.2007.01.014
Autor:
Karolina af Edholm Arvidsson, Per Svenningsson, Carl Rosenblad, Bavani Shankar, Klas Wictorin, David A. Lowe, Charlotte Keywood, Håkan Widner, Anders Björklund
Publikováno v:
Svenningsson, P, Rosenblad, C, Arvidsson, K A E, Wictorin, K, Keywood, C, Shankar, B, Lowe, D A, Björklund, A & Widner, H 2015, ' Eltoprazine counteracts l-DOPA-induced dyskinesias in Parkinson's disease : A dose-finding study ', Brain, vol. 138, no. 4, pp. 963-973 . https://doi.org/10.1093/brain/awu409
Brain; 138(Feb 10), pp 963-973 (2015)
Brain; 138(Feb 10), pp 963-973 (2015)
In advanced stages of Parkinson's disease, serotonergic terminals take up l-DOPA and convert it to dopamine. Abnormally released dopamine may participate in the development of l-DOPA-induced dyskinesias. Simultaneous activation of 5-HT1A and 5-HT1B r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69722784b39675183eb56442a19adcc4
https://kclpure.kcl.ac.uk/ws/files/148083964/Eltoprazine_counteracts_L_DOPA_induced_SVENNINGSSON_Publishedonline5February2015_GOLD_VoR_CC_BY_NC_.pdf
https://kclpure.kcl.ac.uk/ws/files/148083964/Eltoprazine_counteracts_L_DOPA_induced_SVENNINGSSON_Publishedonline5February2015_GOLD_VoR_CC_BY_NC_.pdf
Autor:
Olivia Orozco, Paul Carmillo, Dane S. Worley, Carolyn Buckley, Lee Walus, Richard L. Cate, Carl Rosenblad, Anthony Rossomando, Lone Dagø, Dinah W. Y. Sah, Miller Stephan S, Albert Tse, Eric S. Day, Mette Grønborg, Adrian Whitty
Publikováno v:
Biochemistry. 44:2545-2554
To clarify whether glial cell line-derived neurotrophic factor (GDNF) receptor alpha-1 (GFRalpha1), the glycosylphosphatidylinositol (GPI)-linked coreceptor for GDNF, is also a functional coreceptor for artemin (ART), we have studied receptor binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28bfbe89baa46a494402500af31bc74f
https://doi.org/10.1021/bi049247p
https://doi.org/10.1021/bi049247p
Publikováno v:
European Journal of Neuroscience. 17:260-270
Sustained neurotrophic factor treatment in neurodegenerative disorders such as Parkinson's disease is likely to affect both degenerating and intact neurons. To investigate the effect of long-term glial cell line-derived neurotrophic factor (GDNF) ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b369863e651815b528327a673cb62fe5
https://doi.org/10.1046/j.1460-9568.2003.02456.x
https://doi.org/10.1046/j.1460-9568.2003.02456.x
Publikováno v:
Neuroreport. 13:75-82
We used a recombinantlentiviral vector (rLV) for gene delivery of GDNF to the striatum, and assessed its neuroprotective eiects in the intrastriatal 6 -hydroxydopamine (6 -OHDA) lesion model.The level of GDNF expression obtained with the rLV-GDNF vec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f7d08c4315b4e64ab52ca950fa25874
https://doi.org/10.1097/00001756-200201210-00019
https://doi.org/10.1097/00001756-200201210-00019
Publikováno v:
European Journal of Neuroscience. 13:1589-1599
Here we studied the effects of glial cell line-derived neurotrophic factor (GDNF) in a rat model that represents the symptomatic stages of Parkinson's disease. GDNF was infused starting 2 weeks after an intrastriatal 6-hydroxydopamine (6-OHDA) lesion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c86b42795ee28caa95493b74e17512e0
https://doi.org/10.1046/j.0953-816x.2001.01534.x
https://doi.org/10.1046/j.0953-816x.2001.01534.x
Publikováno v:
European Journal of Neuroscience. 13:1-14
This study was designed to determine whether induction and phosphorylation of the transcription factor c-Jun is associated with lesion-induced death of dopaminergic neurons of the substantia nigra pars compacta, and if this cellular response is modul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8883237aa98185a2a53dce9155d6d695
https://doi.org/10.1111/j.1460-9568.2001.01356.x
https://doi.org/10.1111/j.1460-9568.2001.01356.x
Autor:
Cecilia Lundberg, Klas Wictorin, Carl Rosenblad, Didier Trono, Ronald J. Mandel, Cecilia Ericson, Ulrica Englund
Publikováno v:
NeuroReport. 11:3973-3977
A major obstacle in ex vivo gene transfer has been the loss of transgene expression soon after implantation of the grafted transduced cells. Recently, a lentiviral vector system has been developed which has proven to express high levels of transgenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553502c7975bec02f8e9f2e089040604
https://doi.org/10.1097/00001756-200012180-00014
https://doi.org/10.1097/00001756-200012180-00014