Studies on Neuroprotective and Regenerative Effects of GDNF in a Partial Lesion Model of Parkinson's Disease

Autor: Anders Björklund, Carl Rosenblad, Christian Winkler, Deniz Kirik

Publikováno v: Neurobiology of Disease, Vol 4, Iss 3, Pp 186-200 (1997)

Intrastriatal 6-hydroxydopamine injections in rats induce partial lesions of the nigrostriatal dopamine (DA) system which are accompanied by a delayed and protracted degeneration of DA neurons within the substantia nigra. By careful selection of the

Externí odkaz: https://doaj.org/article/da245300d957474db038a238044788f5

Eltoprazine counteracts l-DOPA-induced dyskinesias in Parkinson's disease:A dose-finding study

Autor: Karolina af Edholm Arvidsson, Per Svenningsson, Carl Rosenblad, Bavani Shankar, Klas Wictorin, David A. Lowe, Charlotte Keywood, Håkan Widner, Anders Björklund

Publikováno v: Svenningsson, P, Rosenblad, C, Arvidsson, K A E, Wictorin, K, Keywood, C, Shankar, B, Lowe, D A, Björklund, A & Widner, H 2015, ' Eltoprazine counteracts l-DOPA-induced dyskinesias in Parkinson's disease : A dose-finding study ', Brain, vol. 138, no. 4, pp. 963-973 . https://doi.org/10.1093/brain/awu409
Brain; 138(Feb 10), pp 963-973 (2015)

In advanced stages of Parkinson's disease, serotonergic terminals take up l-DOPA and convert it to dopamine. Abnormally released dopamine may participate in the development of l-DOPA-induced dyskinesias. Simultaneous activation of 5-HT1A and 5-HT1B r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69722784b39675183eb56442a19adcc4
https://kclpure.kcl.ac.uk/ws/files/148083964/Eltoprazine_counteracts_L_DOPA_induced_SVENNINGSSON_Publishedonline5February2015_GOLD_VoR_CC_BY_NC_.pdf

Long-term striatal overexpression of GDNF selectively downregulates tyrosine hydroxylase in the intact nigrostriatal dopamine system

Autor: Carl Rosenblad, Biljana Georgievska, Deniz Kirik

Publikováno v: European Journal of Neuroscience. 17:260-270

Sustained neurotrophic factor treatment in neurodegenerative disorders such as Parkinson's disease is likely to affect both degenerating and intact neurons. To investigate the effect of long-term glial cell line-derived neurotrophic factor (GDNF) ove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b369863e651815b528327a673cb62fe5
https://doi.org/10.1046/j.1460-9568.2003.02456.x

Delayed infusion of GDNF promotes recovery of motor function in the partial lesion model of Parkinson's disease

Autor: Biljana Georgievska, Carl Rosenblad, Anders Björklund, Deniz Kirik

Publikováno v: European Journal of Neuroscience. 13:1589-1599

Here we studied the effects of glial cell line-derived neurotrophic factor (GDNF) in a rat model that represents the symptomatic stages of Parkinson's disease. GDNF was infused starting 2 weeks after an intrastriatal 6-hydroxydopamine (6-OHDA) lesion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c86b42795ee28caa95493b74e17512e0
https://doi.org/10.1046/j.0953-816x.2001.01534.x

The use of a recombinant lentiviral vector for ex vivo gene transfer into the rat CNS

Autor: Cecilia Lundberg, Klas Wictorin, Carl Rosenblad, Didier Trono, Ronald J. Mandel, Cecilia Ericson, Ulrica Englund

Publikováno v: NeuroReport. 11:3973-3977

A major obstacle in ex vivo gene transfer has been the loss of transgene expression soon after implantation of the grafted transduced cells. Recently, a lentiviral vector system has been developed which has proven to express high levels of transgenes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::553502c7975bec02f8e9f2e089040604
https://doi.org/10.1097/00001756-200012180-00014