Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Carl Roos"'
Autor:
Monika Semmrich, Linda Mårtensson, Ingrid Teige, Björn Frendeus, Mathilda Kovacek, Petra Holmkvist, Carolin Svensson, Therese Blidberg, Carl Roos, Andres McAllister, Mimoza Demiri, Marie Borggren, Ingrid Karlsson
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/baba49f749e844cd8cfdc68f13573c43
Autor:
David Dahlgren, Markus Sjöblom, Christer Tannergren, Anders Lundqvist, Hans Lennernäs, Karsten Peters, Erik Sjögren, Carl Roos
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 142:31-37
The rat single-pass intestinal perfusion (SPIP) model is commonly used to investigate gastrointestinal physiology and membrane drug transport. The SPIP model can be used with the intestinal segment inside or outside the abdomen. The rats can also be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5619b94322d962ff1cb9bc80578edce
https://doi.org/10.1016/j.ejpb.2019.06.011
https://doi.org/10.1016/j.ejpb.2019.06.011
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 142:387-395
Oral administration of drug products is the preferred administration route. In recent decades there has been an increase in drug candidates with low solubility and/or low permeability. To increase the possibility of oral administration for the poorly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8085120f2b9d3f0ac0e247f0ca9a5ed9
https://doi.org/10.1016/j.ejpb.2019.07.012
https://doi.org/10.1016/j.ejpb.2019.07.012
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 133:70-76
Particle size reduction is a traditional approach to increase the intestinal absorption of active pharmaceutical ingredients with poor intestinal solubility, by increasing the particle dissolution rate. However, an increase in the dissolution rate ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68602347615eb2107f161fd0a45cb976
https://doi.org/10.1016/j.ejpb.2018.10.006
https://doi.org/10.1016/j.ejpb.2018.10.006
Autor:
Carl Roos, Björn Frendéus, Mimoza Demiri, Monika Semmrich, Therese Blidberg, Carolin Svensson, Petra Holmkvist, Marie Borggren, Linda Mårtensson, Ingrid Karlsson, Andres McAllister, Mathilda Kovacek, Ingrid Teige
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background The pleiotropic TNF-alpha:TNFR axis plays a central role in the immune system. While the cellular expression of TNFR1 is broad, TNFR2 expression is mainly restricted to immune cells. The therapeutic potential of targeting TNFR2 for cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::604a70c2463f4e4119e9f25a1ca471e7
https://doaj.org/article/baba49f749e844cd8cfdc68f13573c43
https://doaj.org/article/baba49f749e844cd8cfdc68f13573c43
Autor:
Christer Tannergren, Anders Lundqvist, David Dahlgren, Markus Sjöblom, Hans Lennernäs, Erik Sjögren, Carl Roos
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 132:19-28
The relevance of the rat single-pass intestinal perfusion model for investigating in vivo time-dependent effects of absorption-modifying excipients (AMEs) is not fully established. Therefore, the dynamic effect and recovery of the intestinal mucosa w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bacd8a2a86bbda8fa12f33060ef1cc
https://doi.org/10.1016/j.ejpb.2018.09.001
https://doi.org/10.1016/j.ejpb.2018.09.001
Autor:
Ingrid Teige, Raul Cordoba, Hans Hagberg, Ana Carneiro, Pau Abrisqueta, Marie Borggren, Santiago Mercadal, Ingrid Karlsson, Mats Jerkeman, Andres McAllister, Björn Frendéus, Carl Roos, Marie Lindell Andersson
Publikováno v:
Blood. 136:36-37
Introduction BI-1206 is a fully-human IgG1 monoclonal antibody that exquisitely recognizes and blocks FcγRIIB. BI-1206 enhances the activity of anti-CD20 antibodies such as rituximab by preventing interaction with FcγRIIB and may thus overcome resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::526fc8a6a42428783da80809c3e2b12b
https://doi.org/10.1182/blood-2020-140219
https://doi.org/10.1182/blood-2020-140219
Autor:
Stephen A. Beers, Carl Roos, Linda Mårtensson, Sean H. Lim, Mats Jerkeman, Martin J. S. Dyer, Mark S. Cragg, Therese Blidberg, Pau Abrisqueta, Marie Borggren, Björn Frendéus, Andrew Davies, Ingrid Teige, Mathilda Kovacek, Raul Cordoba, Robert J. Oldham, Ingrid Karlsson, Andres McAllister
Publikováno v:
Blood. 136:4-5
Introduction Administration of therapeutic monoclonal antibodies (mAb) is often accompanied by infusion related reactions (IRR), of ill-determined mechanism. During the clinical development of BI-1206 (NCT02933320 and NCT03571568), a fully human mAb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5394f82d0e45cc0d62689fbf43e10b1c
https://doi.org/10.1182/blood-2020-138658
https://doi.org/10.1182/blood-2020-138658
Autor:
Christer Tannergren, David Dahlgren, Hans Lennernäs, Carl Roos, Erik Sjögren, Anders Lundqvist, Pernilla Johansson, Bertil Abrahamsson
Publikováno v:
Molecular Pharmaceutics. 13:3022-3033
The development of oral modified-release (MR) dosage forms requires an active pharmaceutical ingredient (API) with a sufficiently high absorption rate in both the small and large intestine. Dogs are commonly used in preclinical evaluation of regional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4b3aa5e46091b46287280d62c8017c
https://doi.org/10.1021/acs.molpharmaceut.6b00515
https://doi.org/10.1021/acs.molpharmaceut.6b00515
Autor:
Jonas Wilbs, Magnus Fransson, Mats Josefson, Kyrre Thalberg, Catherine Boissier, Carl Roos, Mark Nicholas
Publikováno v:
International Journal of Pharmaceutics. 587:119666
A multivariate TOF-SIMS methodology has been developed and applied to quantify surface composition and chemical distribution for dry powder blends. Surface properties are often critical to the behavior of powder formulations, especially in the case o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9774992d512923c86b05f337e6ce3d
https://doi.org/10.1016/j.ijpharm.2020.119666
https://doi.org/10.1016/j.ijpharm.2020.119666