Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Carl Pelz"'
Autor:
Zinab O. Doha, Xiaoyan Wang, Nicholas L. Calistri, Jennifer Eng, Colin J. Daniel, Luke Ternes, Eun Na Kim, Carl Pelz, Michael Munks, Courtney Betts, Sunjong Kwon, Elmar Bucher, Xi Li, Trent Waugh, Zuzana Tatarova, Dylan Blumberg, Aaron Ko, Nell Kirchberger, Jennifer A. Pietenpol, Melinda E. Sanders, Ellen M. Langer, Mu-Shui Dai, Gordon Mills, Koei Chin, Young Hwan Chang, Lisa M. Coussens, Joe W. Gray, Laura M. Heiser, Rosalie C. Sears
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Triple-negative breast cancer (TNBC) patients have a poor prognosis and few treatment options. Mouse models of TNBC are important for development of new therapies, however, few mouse models represent the complexity of TNBC. Here, we develop
Externí odkaz:
https://doaj.org/article/2f5efa1be7d149bcb492c236e0e02ed5
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Here, authors show that precise integration of an rAAV vector into a chromosomal target locus results in expression of a self-cleaving guide RNA. This recombination event creates genetic resistance to a hepatotoxic compound and enables in vivo expans
Externí odkaz:
https://doaj.org/article/4d08ffa6f2c04842bf58c6c359692c38
Autor:
Soren Impey, Carl Pelz, Lara-Kirstie Riparip, Amanuel Tafessu, Fatema Fareh, Damian G. Zuloaga, Tessa Marzulla, Blair Stewart, Susanna Rosi, Mitchell S. Turker, Jacob Raber
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: The response of the brain to space radiation is an important concern for astronauts during space missions. Therefore, we assessed the response of the brain to 28Si ion irradiation (600 MeV/n), a heavy ion present in the space environmen
Externí odkaz:
https://doaj.org/article/4be93f0a04c94841bb5caa5bc706d91a
Autor:
Vidhi M. Shah, Syed Rizvi, Alexander Smith, Motoyuki Tsuda, Madeline Krieger, Carl Pelz, Kevin MacPherson, Jenny Eng, Koei Chin, Michael W. Munks, Colin J. Daniel, Adel Al-Fatease, Galip Gürkan Yardimci, Ellen M. Langer, Jonathan R. Brody, Brett C. Sheppard, Adam WG. Alani, Rosalie C. Sears
Publikováno v:
Pharmaceutics, Vol 15, Iss 12, p 2651 (2023)
Pancreatic cancer remains a formidable challenge due to limited treatment options and its aggressive nature. In recent years, the naturally occurring anticancer compound juglone has emerged as a potential therapeutic candidate, showing promising resu
Externí odkaz:
https://doaj.org/article/e9a791e9964242ceae9c1bd09d990aef
Autor:
Bin Li, Yuhan Wang, Carl Pelz, Josh Moss, Ruth Shemer, Yuval Dor, Yassmine K. Akkari, Pamela S. Canady, Willscott E. Naugler, Susan Orloff, Markus Grompe
Publikováno v:
Stem Cell Research, Vol 56, Iss , Pp 102523- (2021)
Background & aims: Mature hepatocytes have limited expansion capability in culture and rapidly loose key functions. Recently however, tissue culture conditions have been developed that permit rodent hepatocytes to proliferate and transform into proge
Externí odkaz:
https://doaj.org/article/8a43b9dd01524af5888516e470070fb3
Autor:
Amy S. Farrell, Meghan Morrison Joly, Brittany L. Allen-Petersen, Patrick J. Worth, Christian Lanciault, David Sauer, Jason Link, Carl Pelz, Laura M. Heiser, Jennifer P. Morton, Nathiya Muthalagu, Megan T. Hoffman, Sara L. Manning, Erica D. Pratt, Nicholas D. Kendsersky, Nkolika Egbukichi, Taylor S. Amery, Mary C. Thoma, Zina P. Jenny, Andrew D. Rhim, Daniel J. Murphy, Owen J. Sansom, Howard C. Crawford, Brett C. Sheppard, Rosalie C. Sears
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Neuroendocrine differentiation of epithelial tumor cells can contribute to cancer cell resistance and survival. Here, the authors show that dysregulated c-Myc promotes neuroendocrine differentiation in pancreatic ductal adenocarcinoma, leading to poo
Externí odkaz:
https://doaj.org/article/dc766b609bac46f8805ef957d3259818
Autor:
Bin Li, Craig Dorrell, Pamela S. Canaday, Carl Pelz, Annelise Haft, Milton Finegold, Markus Grompe
Publikováno v:
Stem Cell Reports, Vol 9, Iss 2, Pp 478-489 (2017)
Summary: The biliary system plays an important role in several acquired and genetic disorders of the liver. We have previously shown that biliary duct epithelium contains cells giving rise to proliferative Lgr5+ organoids in vitro. However, it remain
Externí odkaz:
https://doaj.org/article/16429bd5f2ac4c2cb4ca9eefa52d4732
Autor:
Eileen Ruth S. Torres, Reed Hall, Gerd Bobe, Jaewoo Choi, Soren Impey, Carl Pelz, Jonathan R. Lindner, Jan F. Stevens, Jacob Raber
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2019)
In this study, an untargeted metabolomics approach was used to assess the effects of proton irradiation (1 Gy of 150 MeV) on the metabolome and DNA methylation pattern in the murine hippocampus and left ventricle of the heart 22 weeks following expos
Externí odkaz:
https://doaj.org/article/107b200dea384dc38704b48a5cd2271e
Autor:
Qing-Shuo Zhang, Matthew Deater, Kathryn Schubert, Laura Marquez-Loza, Carl Pelz, David A. Sinclair, Markus Grompe
Publikováno v:
Stem Cell Research, Vol 15, Iss 1, Pp 130-140 (2015)
Fanconi anemia is a genetic bone marrow failure syndrome. The current treatment options are suboptimal and do not prevent the eventual onset of aplastic anemia requiring bone marrow transplantation. We previously showed that resveratrol, an antioxida
Externí odkaz:
https://doaj.org/article/a809e38fe36d45ec870375f4407bda2d
Autor:
Qing-Shuo Zhang, Eric Benedetti, Matthew Deater, Kathryn Schubert, Angela Major, Carl Pelz, Soren Impey, Laura Marquez-Loza, R. Keaney Rathbun, Shigeaki Kato, Grover C. Bagby, Markus Grompe
Publikováno v:
Stem Cell Reports, Vol 4, Iss 1, Pp 90-102 (2015)
Summary: Androgens are widely used for treating Fanconi anemia (FA) and other human bone marrow failure syndromes, but their mode of action remains incompletely understood. Aged Fancd2−/− mice were used to assess the therapeutic efficacy of oxyme
Externí odkaz:
https://doaj.org/article/8a6306b4c4804260b2652a1314bac711