Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Carl O. Postenka"'
Autor:
Hon S. Leong, Amy E. Robertson, Konstantin Stoletov, Sean J. Leith, Curtis A. Chin, Andrew E. Chien, M. Nicole Hague, Amber Ablack, Katia Carmine-Simmen, Victor A. McPherson, Carl O. Postenka, Eva A. Turley, Sara A. Courtneidge, Ann F. Chambers, John D. Lewis
Publikováno v:
Cell Reports, Vol 8, Iss 5, Pp 1558-1570 (2014)
Tumor cell extravasation is a key step during cancer metastasis, yet the precise mechanisms that regulate this dynamic process are unclear. We utilized a high-resolution time-lapse intravital imaging approach to visualize the dynamics of cancer cell
Externí odkaz:
https://doaj.org/article/8c78d3b31e9a449eb0c66822ac1f735e
Publikováno v:
Clinical & Experimental Metastasis
Circulating tumor cells (CTCs) present an opportunity to detect/monitor metastasis throughout disease progression. The CellSearch® is currently the only FDA-approved technology for CTC detection in patients. The main limitation of this system is its
Autor:
Milica Krstic, Alan B. Tuck, Pieter H. Anborgh, Ann F. Chambers, Haider M. Hassan, Bart Kolendowski, Joseph Torchia, Carl O. Postenka, M. Nicole Hague
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
TBX3 is a member of the highly conserved family of T-box transcription factors involved in embryogenesis, organogenesis and tumor progression. While the functional role of TBX3 in tumorigenesis has been widely studied, less is known about the specifi
Autor:
Milica Krstic, Joseph Torchia, Connor D MacMillan, Haider M. Hassan, Karla C. Williams, Joseph Andrews, Ann F. Chambers, Carl O. Postenka, Matthew J. Cecchini, Alan B. Tuck, Bart Kolendowski, Muriel Brackstone, Hon S. Leong
Publikováno v:
Paediatrics Publications
The Journal of Pathology
The Journal of Pathology
The acquisition of cellular invasiveness by breast epithelial cells and subsequent transition from ductal carcinoma in situ (DCIS) to invasive breast cancer is a critical step in breast cancer progression. Little is known about the molecular dynamics
Autor:
David Goodale, Alison L. Allan, Karla C. Williams, Braeden Medeiros, Carl O. Postenka, Patti K. Kiser, Lori E. Lowes, Stephen Hearn, Nikki Salmond
Publikováno v:
Cancers
Cancers, Vol 12, Iss 1, p 172 (2020)
Volume 12
Issue 1
Cancers, Vol 12, Iss 1, p 172 (2020)
Volume 12
Issue 1
The lung is one of the deadliest sites of breast cancer metastasis, particularly in patients with triple-negative (TN) disease. We hypothesized that the presence of a TN primary breast tumor induces changes in the extracellular matrix (ECM) and solub
Autor:
Nicholas Power, Matthew D. Hammers, Siddika Pardhan, Ann F. Chambers, Hon S. Leong, Megan Verrydt, Carl O. Postenka, Alp Sener, Ian Lobb, Chantalle J. Willie, Clarisse R. Mazzola, Michael D. Pluth, Eric Sonke
Publikováno v:
Nitric Oxide. 49:26-39
Clear cell renal cell carcinoma (ccRCC) is characterized by Von Hippel-Lindau (VHL)-deficiency, resulting in pseudohypoxic, angiogenic and glycolytic tumours. Hydrogen sulfide (H2S) is an endogenously-produced gasotransmitter that accumulates under h
Autor:
J-A Chapman, L. Han, Lois E. Shepherd, Colin H Wilson, Alan B. Tuck, Carl O. Postenka, Ann F. Chambers, Vivien H.C. Bramwell, Michael Pollak, Pieter H. Anborgh, Kathleen I. Pritchard
Publikováno v:
Cancer Research. 71:P2-12
Background We have shown, in women with metastatic breast cancer (BC), that high baseline plasma osteopontin (OPN) levels and increases over time are associated with poor survival. In primary BC, increased immunohistochemical (IHC) expression of OPN
Autor:
Ann F. Chambers, Alan B. Tuck, John D. Lewis, Carl O. Postenka, Joe S. Mymryk, Vincent Giguère, Wendy Kennette, M. Nicole Hague, Brigitte Goulet, Amber Ablack
Publikováno v:
ResearcherID
Maspin (mammary serine protease inhibitor or SerpinB5) acts as a tumor suppressor when overexpressed in aggressive cancer cell lines. However, its role in human cancer is controversial. Maspin expression has been associated with a poor prognosis in s
Autor:
Hon S. Leong, Guihua Zhang, David I. Rodenhiser, Ann F. Chambers, Amy C. Cook, Joseph Andrews, Lesley H. Souter, Waleed Al-Katib, Alan B. Tuck, Carl O. Postenka
Publikováno v:
Pathology Publications
Early breast cancer progression involves advancement through specific morphological stages including atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS) and invasive mammary carcinoma (IMC), although not necessarily always in a linear
Publikováno v:
Cytometry Part A. :344-355
The inability to sensitively detect metastatic cells in preclinical models of cancer has created challenges for studying metastasis in experimental systems. We previously developed a flow cytometry (FCM) method for quantifying circulating tumor cells