Výsledky vyhledávání - "Carl O Olson"

Akademický článek

Brain region-specific expression of MeCP2 isoforms correlates with DNA methylation within Mecp2 regulatory elements.

Autor: Carl O Olson, Robby M Zachariah, Chinelo D Ezeonwuka, Vichithra R B Liyanage, Mojgan Rastegar

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e90645 (2014)

MeCP2 is a critical epigenetic regulator in brain and its abnormal expression or compromised function leads to a spectrum of neurological disorders including Rett Syndrome and autism. Altered expression of the two MeCP2 isoforms, MeCP2E1 and MeCP2E2

Externí odkaz: https://doaj.org/article/047f4ba6b42345e188dbaa95e4f78880

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Akademický článek

Novel MeCP2 isoform-specific antibody reveals the endogenous MeCP2E1 expression in murine brain, primary neurons and astrocytes.

Autor: Robby M Zachariah, Carl O Olson, Chinelo Ezeonwuka, Mojgan Rastegar

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e49763 (2012)

Rett Syndrome (RTT) is a severe neurological disorder in young females, and is caused by mutations in the X-linked MECP2 gene. MECP2/Mecp2 gene encodes for two protein isoforms; MeCP2E1 and MeCP2E2 that are identical except for the N-terminus region

Externí odkaz: https://doaj.org/article/80e9475b280a4978b3e7791de294ed18

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Genome-Wide Transcriptome Landscape of Embryonic Brain-Derived Neural Stem Cells Exposed to Alcohol with Strain-Specific Cross-Examination in BL6 and CD1 Mice

Autor: Carl O. Olson, Robby M. Zachariah, Geoffrey G. Hicks, Wayne Xu, Romina D. Levy, Aaron MacAulay, James R. Davie, Kyle Curtis, Marjorie Buist, Shayan Amiri, Mojgan Rastegar, Vichithra R. B. Liyanage

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Scientific Reports

We have previously reported the deregulatory impact of ethanol on global DNA methylation of brain-derived neural stem cells (NSC). Here, we conducted a genome-wide RNA-seq analysis in differentiating NSC exposed to different modes of ethanol exposure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa709a92ef5bb0aa0aa4cfe884c2607
http://link.springer.com/article/10.1038/s41598-018-36059-y

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DNA Methylation Contributes to the Differential Expression Levels of

Autor: Vichithra R B, Liyanage, Carl O, Olson, Robby M, Zachariah, James R, Davie, Mojgan, Rastegar

Publikováno v: International Journal of Molecular Sciences

Methyl CpG binding protein-2 (MeCP2) isoforms (E1 and E2) are important epigenetic regulators in brain cells. Accordingly, MeCP2 loss- or gain-of-function mutation causes neurodevelopmental disorders, including Rett syndrome (RTT), MECP2 duplication

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5713cc3d86aab42b2c6ee881f186bc15
https://pubmed.ncbi.nlm.nih.gov/31013990

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Involvement of D1 and D2 dopamine receptors in the antidepressant-like effects of selegiline in maternal separation model of mouse

Autor: Carl O. Olson, Hossein Amini-Khoei, Shayan Amiri, Sakineh Alijanpour, Ali Razmi, Ali Mohammadi-Asl, Mehdi Mehdizadeh, Mojgan Rastegar, Maryam Rahimi-Balaei, Arya Haj-Mirzaian, Mohammad-Reza Zarrindast

Publikováno v: Physiology & Behavior. 163:107-114

Mother-infant interactions are known to be associated with the psychological well-being of an individual in adulthood. It is well accepted that emotional stress in early life, such as maternal separation (MS), leads to alterations in the neurotransmi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6803998c7c9400df02c0f7f0d49244
https://doi.org/10.1016/j.physbeh.2016.04.052

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MECP2 Mutation Interrupts Nucleolin–mTOR–P70S6K Signaling in Rett Syndrome Patients

Autor: Annan Ali Sher, Marjorie Buist, Marc R. Del Bigio, Victoria Mok Siu, Shervin Pejhan, Marianne Sabourin-Felix, Mojgan Rastegar, Tom Moss, Carl O. Olson, David Fuss, Lee Cyn Ang, Daniel Kroft, Kimia Sheikholeslami, Yehezkel Sztainberg

Publikováno v: Frontiers in Genetics, Vol 9 (2018)
Frontiers in Genetics

Rett syndrome (RTT) is a severe and rare neurological disorder that is caused by mutations in the X-linked MECP2 (methyl CpG-binding protein 2) gene. MeCP2 protein is an important epigenetic factor in the brain and in neurons. In Mecp2-deficient neur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dff5424731a528dfec9f575f3d09dbb2

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Protective effects of gabapentin against the seizure susceptibility and comorbid behavioral abnormalities in the early socially isolated mice

Autor: Arya Haj-Mirzaian, Armin Shirzadian, Mohammad-Reza Zarrindast, Maryam Rahimi-Balaei, Shayan Amiri, Arman Mohsenzadeh, Carl O. Olson, Ali Razmi, Hossein Amini-Khoei, Mojgan Rastegar, Mahmoud Ghazi-Khansari

Publikováno v: European journal of pharmacology. 797

Adolescence is a pivotal period of brain development during lifespan, which is sensitive to stress exposure. Early social isolation stress (SIS) is known to provoke a variety of psychiatric comorbidities as well as seizure risk. Psychiatric comorbidi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712e3e7a5fe5e48e9488b47a32bbaaf7
https://pubmed.ncbi.nlm.nih.gov/28115172

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Identification of connexin36 in gap junctions between neurons in rodent locus coeruleus

Autor: N. Kamasawa, James I. Nagy, Carl O. Olson, John E. Rash, Thomas Yasumura, Kimberly G. V. Davidson

Publikováno v: Neuroscience. 147:938-956

Locus coeruleus neurons are strongly coupled during early postnatal development, and it has been proposed that these neurons are linked by extraordinarily abundant gap junctions consisting of connexin32 and connexin26, and that those same connexins a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d1a9b9dde5650bb4219e3f0ca1f414
https://doi.org/10.1016/j.neuroscience.2007.04.061

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