Výsledky vyhledávání - "Carl N. Wivagg"

Akademický článek

MreB filaments align along greatest principal membrane curvature to orient cell wall synthesis

Autor: Saman Hussain, Carl N Wivagg, Piotr Szwedziak, Felix Wong, Kaitlin Schaefer, Thierry Izoré, Lars D Renner, Matthew J Holmes, Yingjie Sun, Alexandre W Bisson-Filho, Suzanne Walker, Ariel Amir, Jan Löwe, Ethan C Garner

Publikováno v: eLife, Vol 7 (2018)

MreB is essential for rod shape in many bacteria. Membrane-associated MreB filaments move around the rod circumference, helping to insert cell wall in the radial direction to reinforce rod shape. To understand how oriented MreB motion arises, we alte

Externí odkaz: https://doaj.org/article/416725f762834c18a4e88f2e574f2fa6

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Akademický článek

Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment

Autor: James E Gomez, Benjamin B Kaufmann-Malaga, Carl N Wivagg, Peter B Kim, Melanie R Silvis, Nikolai Renedo, Thomas R Ioerger, Rushdy Ahmad, Jonathan Livny, Skye Fishbein, James C Sacchettini, Steven A Carr, Deborah T Hung

Publikováno v: eLife, Vol 6 (2017)

Antibiotic resistance arising via chromosomal mutations is typically specific to a particular antibiotic or class of antibiotics. We have identified mutations in genes encoding ribosomal components in Mycobacterium smegmatis that confer resistance to

Externí odkaz: https://doaj.org/article/055cbdc4cceb4d06980229734602efd9

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Transcriptomic analysis of pathways associated with ITGAV/alpha(v) integrin-dependent autophagy in human B cells

Autor: Virginia Muir, Sara Sagadiev, Shuozhi Liu, Ursula Holder, Andrea M. Armendariz, Emmaline Suchland, Iana Meitlis, Nathan Camp, Natalia Giltiay, Jenny M. Tam, Ethan C. Garner, Carl N. Wivagg, Donna Shows, Richard G. James, Adam Lacy-Hulbert, Mridu Acharya

Publikováno v: Autophagy.

Macroautophagy/autophagy proteins have been linked with the development of immune-mediated diseases including lupus, but the mechanisms for this are unclear due to the complex roles of these proteins in multiple immune cell types. We have previously

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ebe0c1d5175c04aad2ca7e8b60f0e5
https://pubmed.ncbi.nlm.nih.gov/36016494

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Transcriptomic analysis of pathways associated with αv integrin-related non-canonical autophagy in human B cells

Autor: N. Giltiay, E. Suchland, I. Meitlis, Virginia S. Muir, Richard G. James, M. Acharya, Carl N. Wivagg, D. Shows, Adam Lacy-Hulbert, Jenny M. Tam, S. Sagadiev, Ethan C. Garner

Autophagy proteins have been linked with development of immune-mediated diseases including lupus, but the mechanisms for this are unclear. We have previously shown that non-canonical autophagy induced by αv-integrins regulates B cell activation by v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb146b71b72de2fcda4b0efa2634cb33
https://doi.org/10.1101/2021.08.02.452710

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Tetraspanin CD82 Organizes Dectin-1 into Signaling Domains to Mediate Cellular Responses to Candida albicans

Publikováno v: Journal of Immunology, 202(11), 3256-3266. AMER ASSOC IMMUNOLOGISTS
Journal of Immunology, 202, 11, pp. 3256-3266
Journal of Immunology, 202, 3256-3266
J Immunol

Tetraspanins are a family of proteins possessing four transmembrane domains that help in lateral organization of plasma membrane proteins. These proteins interact with each other as well as other receptors and signaling proteins, resulting in functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec72eed26a79817342b8c21c7369e075
https://doi.org/10.4049/jimmunol.1801384

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Baeyer-Villiger Monooxygenases EthA and MymA Are Required for Activation of Replicating and Non-replicating Mycobacterium tuberculosis Inhibitors

Autor: Nathan Haseley, Michael Fitzgerald, Raymond M. Nietupski, Matthew Thompson, Melanie R. Silvis, Noriaki Iwase, Sarah Schmidt Grant, Carl N. Wivagg, Katherine Gordon, Edward Kazyanskaya, Deborah T. Hung, Tomohiko Kawate, Ashlee M. Earl, Samantha Wellington, Christopher A. Desjardins

Publikováno v: Cell Chemical Biology. 23(6):666-677

Summary Successful treatment of Mycobacterium tuberculosis infection typically requires a complex regimen administered over at least 6 months. Interestingly, many of the antibiotics used to treat M. tuberculosis are prodrugs that require intracellula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4359c0b0aa02d83c310de090fff30f40

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Loss of a Class A Penicillin-Binding Protein Alters β-Lactam Susceptibilities in Mycobacterium tuberculosis

Autor: James Gomez, Samantha Wellington, Carl N. Wivagg, Deborah T. Hung

Publikováno v: ACS Infectious Diseases. 2:104-110

Recent studies have renewed interest in β-lactam antibiotics as a potential treatment for Mycobacterium tuberculosis infection. To explore the opportunities and limitations of this approach, we sought to better understand potential resistance mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86fd8006ec7c689c5e48e07c05227e0c
https://doi.org/10.1021/acsinfecdis.5b00119

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