Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Carl N Sprung"'
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173788 (2017)
PURPOSE:Fibrosis can be a disabling, severe side effect of radiotherapy that can occur in patients, and for which there is currently no effective treatment. The activins, proteins which are members of the TGFβ superfamily, have a major role in stimu
Externí odkaz:
https://doaj.org/article/03f775f04c3846ce9eef5b92b44c7699
Autor:
Helen B Forrester, Alesia Ivashkevich, Michael J McKay, Trevor Leong, David M de Kretser, Carl N Sprung
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77119 (2013)
Follistatin is a potent regulator of the inflammatory response and binds to and inhibits activin A action. Activin A is a member of the TGFβ protein superfamily which has regulatory roles in the inflammatory response and in the fibrotic process. Fib
Externí odkaz:
https://doaj.org/article/a543d001501c4ba980f876a7a1484090
Autor:
Helen B Forrester, Peter Temple-Smith, Seungmin Ham, David de Kretser, Graeme Southwick, Carl N Sprung
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59056 (2013)
Dupuytren's disease (DD) is a classic example of pathological fibrosis which results in a debilitating disorder affecting a large sector of the human population. It is characterized by excessive local proliferation of fibroblasts and over-production
Externí odkaz:
https://doaj.org/article/6b7ddbeab9384750af47ddf09ab37e1a
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e53358 (2012)
DNA repair is an essential cellular process required to maintain genomic stability. Every cell is subjected to thousands of DNA lesions daily under normal physiological conditions. Ionizing radiation (IR) is a major DNA damaging agent that can be pro
Externí odkaz:
https://doaj.org/article/a4c734f8fc874654be947dc320d320a5
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25758 (2011)
Humans are exposed to the DNA damaging agent, ionizing radiation (IR), from background radiation, medical treatments, occupational and accidental exposures. IR causes changes in transcription, but little is known about alternative transcription in re
Externí odkaz:
https://doaj.org/article/618d75e3c9ec4d72836d6d2414cb24a0
Autor:
Olga A. Martin, Carl N. Sprung, Alexandros G. Georgakilas, Vassilis G. Gorgoulis, Ioannis S. Pateras, Georgia Terzoudi, Konstantinos Skordylis, Gianna Potsi, Gerasimos Ch. Pollakis, Vasilis Kotsaris, Andreas Ntargaras, Christopher J. Hall, Andrew W. Stevenson, Alesia Ivashkevich, Nicole M. Haynes, Helen Forrester, Jason S. Palazzolo, Pavel N. Lobachevsky, Jessica Ventura
Supplementary Data include: 1) extended methodology and additional references, 2) tables related to the experimental design, 3) figures: S1 (experimental design) and S2-S8 (related to additional analysis of DNA damage, other genotoxic markers and imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07261c1a3cb43f87e545c18d19f271af
https://doi.org/10.1158/0008-5472.22416753
https://doi.org/10.1158/0008-5472.22416753
Autor:
Olga A. Martin, Carl N. Sprung, Alexandros G. Georgakilas, Vassilis G. Gorgoulis, Ioannis S. Pateras, Georgia Terzoudi, Konstantinos Skordylis, Gianna Potsi, Gerasimos Ch. Pollakis, Vasilis Kotsaris, Andreas Ntargaras, Christopher J. Hall, Andrew W. Stevenson, Alesia Ivashkevich, Nicole M. Haynes, Helen Forrester, Jason S. Palazzolo, Pavel N. Lobachevsky, Jessica Ventura
The importance of nontargeted (systemic) effects of ionizing radiation is attracting increasing attention. Exploiting synchrotron radiation generated by the Imaging and Medical Beamline at the Australian Synchrotron, we studied radiation-induced nont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01210a2907b7b553e619e666953c19f8
https://doi.org/10.1158/0008-5472.c.6509640
https://doi.org/10.1158/0008-5472.c.6509640
Autor:
Pavel Lobachevsky, Helen B. Forrester, Alesia Ivashkevich, Joel Mason, Andrew W. Stevenson, Chris J. Hall, Carl N. Sprung, Valentin G. Djonov, Olga A. Martin
Publikováno v:
Lobachevsky, Pavel; Forrester, Helen B.; Ivashkevich, Alesia; Mason, Joel; Stevenson, Andrew W.; Hall, Chris J.; Sprung, Carl N.; Djonov, Valentin G.; Martin, Olga A. (2021). Synchrotron X-Ray Radiation-Induced Bystander Effect: An Impact of the Scattered Radiation, Distance From the Irradiated Site and p53 Cell Status. Frontiers in oncology, 11, p. 685598. Frontiers Research Foundation 10.3389/fonc.2021.685598
Frontiers in Oncology, Vol 11 (2021)
Frontiers in Oncology
Frontiers in Oncology, Vol 11 (2021)
Frontiers in Oncology
Synchrotron radiation, especially microbeam radiotherapy (MRT), has a great potential to improve cancer radiotherapy, but non-targeted effects of synchrotron radiation have not yet been sufficiently explored. We have previously demonstrated that scat
Autor:
Georgia I. Terzoudi, Andrew W. Stevenson, Chris Hall, Lina Giannakandropoulou, Pavel Lobachevsky, Helen B. Forrester, Jessica Ventura, Carl N. Sprung, Gerasimos Ch Pollakis, Nicole M. Haynes, Alexandros G. Georgakilas, Ioannis S. Pateras, John A. Hamilton, Jason S. Palazzolo, Vassilis G. Gorgoulis, Joel Mason, Olga A. Martin
Publikováno v:
International journal of radiation oncology, biology, physics. 103(5)
Purpose Nontargeted effects of ionizing radiation, by which unirradiated cells and tissues are also damaged, are a relatively new paradigm in radiobiology. We recently reported radiation-induced abscopal effects (RIAEs) in normal tissues; namely, DNA
Autor:
Rory Muddle, Gerald B Fogarty, Wei Chen, Carl N. Sprung, David L. Duffy, Richard A. Sturm, Michael J. McKay
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 77:1486-1492
Purpose The melanocortin-1 receptor (MC1R) regulates melanin biogenesis. Deoxyribonucleic acid sequence variants in the form of single nucleotide polymorphisms (SNPs) of MC1R affect melanin expression and are linked to skin phenotype. We aimed to det