Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Carl M. Knable"'
Autor:
Ajit S. Shah, Thomas Rogers, James Murphy, Bruce E. Wise, D. Keith Anderson, Harish K. Santhanam, Mark A. Pietz, H. Peter Kleine, Derek B. Brown, V. H. Iskos, Jerry D. Clark, Melissa K. Lantz, Christine M. V. Moore, David V. Banaszak, Peter G. Ruminski, Czyzewski Ann M, Carlos A. Orihuela, Puneh S. Forouzi, Carl M. Knable, Gerald A. Weisenburger, Frank W. Muellner, Mark A. Lapack, Schilke Tobin C, Donald J. Gallagher, Albert D. Edeny, Ahmad Y. Sheikh
Publikováno v:
Organic Process Research & Development. 13:1088-1093
Studies directed toward the process research, development, and scale-up preparation of the potential αvβ3 integrin antagonist 1 are described. A convergent approach is detailed wherein tetrahydropyrimidine hydroxybenzoic acid 2 is linked to the β-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::733dff69b6ebf02a64d61a4be7a9b658
https://doi.org/10.1021/op900173f
https://doi.org/10.1021/op900173f
Autor:
Edney Albert D, Carl M. Knable, Puneh S. Karbin, Mark A. Pietz, D. Keith Anderson, Jerry D. Clark, Gerald A. Weisenburger, Donald J. Gallagher
Publikováno v:
Organic Process Research & Development. 13:60-63
The process development of a peptide coupling with CDI is discussed. Various solvents, addition orders, stoichiometries, and reaction temperatures were investigated. A reliable crystallization procedure was also developed. The new process was piloted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3fac081742f6e05a791de8ebfe6610e
https://doi.org/10.1021/op8002213
https://doi.org/10.1021/op8002213
Autor:
Edney Albert D, Carl M. Knable, Pierre-Jean Colson, D. Keith Anderson, Thomas Rogers, Donald J. Gallagher, Ajit S. Shah, H. Peter Kleine, Jerry D. Clark, James Murphy, Christine M. V. Moore, Neil Storer, Bruce E. Wise, Peter G. Ruminski, Gerald A. Weisenburger, Melissa K. Lantz
Publikováno v:
Organic Process Research & Development. 8:51-61
Described are four process research investigations directed toward discerning a scalable, enantioselective method for preparing (S)-β-amino acid ester 3, a key intermediate to the αvβ3 integrin antagonist 1. Reported are an asymmetric Michael reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54f87a82dd31eb7ccfa9af86ec1e1272
https://doi.org/10.1021/op034094j
https://doi.org/10.1021/op034094j
Autor:
Gerald A. Weisenburger, D. Keith Anderson, Jerry D. Clark, Albert D. Edney, Puneh S. Karbin, Donald J. Gallagher, Carl M. Knable, Mark A. Pietz
Publikováno v:
Organic Process Research & Development; Jan2009, Vol. 13 Issue 1, p60-63, 4p