Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Carl LeBel"'
Autor:
Joel Rousseau, Nicolas Dumont, Carl Lebel, Simon P. Quenneville, Claude H. Côté, Jérome Frenette, Jacques P. Tremblay Ph.D.
Publikováno v:
Cell Transplantation, Vol 19 (2010)
Duchenne muscular dystrophy (DMD) is the most frequent muscular dystrophy. Currently, there is no cure for the disease. The transplantation of muscle precursor cells (MPCs) is one of the possible treatments, because it can restore the expression of d
Externí odkaz:
https://doaj.org/article/7bc060e599da45178f401ec77310a909
Autor:
Jared J. Hartsock, Nils Prenzler, Christina L. Runge, Thomas Lenarz, Will Mclean, Jeffrey S. Rosenbloom, Ashley S. Hinton, Steven D. Rauch, René H. Gifford, George Atiee, Alec N. Salt, Susan King, Sam Wilson, Moraye Bear, Jeffrey M. Karp, Christopher R. Loose, Jenna T.J. Herby, Carl Lebel, David L. Lucchino, Lance E. Jackson, Daniel J. Lee, Robert Langer, Athanasia Warnecke, H Schmitt
Publikováno v:
Otology & Neurotology
Objectives There are no approved pharmacologic therapies for chronic sensorineural hearing loss (SNHL). The combination of CHIR99021+valproic acid (CV, FX-322) has been shown to regenerate mammalian cochlear hair cells ex vivo. The objectives were to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03811253e2a9a6476058ba969ed7f98d
http://europepmc.org/articles/PMC8279894
http://europepmc.org/articles/PMC8279894
Publikováno v:
Annals of Otology, Rhinology & Laryngology. 128:524-533
Objectives: OTO-201 is a ciprofloxacin otic suspension previously approved by the US Food and Drug Administration to treat children with bilateral otitis media with effusion requiring tympanostomy tube placement. In this phase 3, double-blind, random
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::921343c75737e4d4f6f3bde3c7a4f992
https://doi.org/10.1177/0003489419830116
https://doi.org/10.1177/0003489419830116
Publikováno v:
Otology & Neurotology
Objective To evaluate safety and efficacy of a single intratympanic injection of OTO-104, sustained-exposure dexamethasone, in patients with unilateral Meniere's disease. Study design Randomized, double-blind, placebo-controlled, Phase 2b study over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce86019fd5ceb29c64a200ebc12a4217
http://europepmc.org/articles/PMC5414596
http://europepmc.org/articles/PMC5414596
Publikováno v:
Otolaryngology--Head and Neck Surgery
Objective To investigate the efficacy, safety, and microbiology of a thermosensitive otic suspension of ciprofloxacin (OTO-201) in children with bilateral middle ear effusion undergoing tympanostomy tube placement. Study Design Two randomized, double
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2f487d23c18bd56330d50dcdac21fe
http://europepmc.org/articles/PMC4971606
http://europepmc.org/articles/PMC4971606
Autor:
Allen F. Ryan, Luis A. Dellamary, Anne Harrop-Jones, Xiaobo Wang, Rayne Fernandez, Carl Lebel, Fabrice Piu
Publikováno v:
Audiology and Neurotology. 21:22-29
The otoprotective effects of OTO-104 were investigated both prior to and following acute acoustic trauma. Guinea pigs received a single intratympanic injection of OTO-104 and were assessed in a model of acute acoustic trauma. Doses of at least 2.0% O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5aaa9239159cb7830fcd4f46b937a16
https://doi.org/10.1159/000441833
https://doi.org/10.1159/000441833
Autor:
Anne Harrop-Jones, Xiaobo Wang, Rayne Fernandez, Luis Dellamary, Allen F. Ryan, Carl LeBel, Fabrice Piu
Publikováno v:
Audiology and Neurotology. 21:12-21
The otoprotective effects of OTO-104 were investigated both prior to and following acute acoustic trauma. Guinea pigs received a single intratympanic injection of OTO-104 and were assessed in a model of acute acoustic trauma. Doses of at least 2.0% O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2cffa253dc62a442c7d093afbf13f42
https://doi.org/10.1159/000441814
https://doi.org/10.1159/000441814
Autor:
Eric A. Mair, Patrick J. Antonelli, Carl LeBel, Moraye Bear, Joseph E. Dohar, Jonathan R. Moss
Publikováno v:
The Annals of Otology, Rhinology, and Laryngology
Objective: This exploratory clinical trial evaluated the safety and clinical activity of a novel, sustained-exposure formulation of ciprofloxacin microparticulates in poloxamer (OTO-201) administered during tympanostomy tube placement in children. Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::452cc9db9c35ad02432070f347d2bf58
https://doi.org/10.1177/0003489415599001
https://doi.org/10.1177/0003489415599001
Autor:
Tsivkovskaia Natalia, Richard A. Altschuler, David F. Dolan, Luis A. Dellamary, Rayne Fernandez, Huiying J. Hou, Anne Harrop-Jones, Fabrice Piu, Carl Lebel, Xiaobo Wang
Publikováno v:
Otology & Neurotology
Hypothesis OTO-201 can provide sustained release to the middle ear and effectively treat otitis media, when compared with FDA-approved ciprofloxacin otic drop formulations. Background There is an unmet medical need for antibiotic therapy that can pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d3307003f43f202385f64ae0c0e1f9
https://doi.org/10.1097/mao.0000000000000261
https://doi.org/10.1097/mao.0000000000000261
Publikováno v:
JAMA otolaryngology-- headneck surgery. 142(5)
Otorrhea after tympanostomy tube placement (TTP) in children is common. Although not approved by the US Food and Drug Administration, antibiotic ear drops are routinely used intraoperatively and prescribed for multidose, multiday postoperative admini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1f514a4d579cb11478285713319593
https://pubmed.ncbi.nlm.nih.gov/26985629
https://pubmed.ncbi.nlm.nih.gov/26985629