Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Carl Laflamme"'
Autor:
Rachel J. Harding, Carl Laflamme, Sara González Bolívar, Aled M. Edwards, Kathleen Southern, Rebeka Fanti, Riham Ayoubi, Charles Alende, Maryam Fotouhi, Renu Chandrasekaran
Publikováno v:
F1000Research, Vol 13 (2024)
Huntingtin encodes a 3144 amino acid protein, with a polyglutamine repeat tract at the N-terminus. Expansion of this repeat tract above a pathogenic threshold of 36 repeats is the causative mutation of Huntington's disease, a neurodegenerative disord
Externí odkaz:
https://doaj.org/article/4a5893b8570c4bb6a47f872075702b74
Autor:
Richard A Kahn, Harvinder Virk, Carl Laflamme, Douglas W Houston, Nicole K Polinski, Rob Meijers, Allan I Levey, Clifford B Saper, Timothy M Errington, Rachel E Turn, Anita Bandrowski, James S Trimmer, Meghan Rego, Leonard P Freedman, Fortunato Ferrara, Andrew RM Bradbury, Hannah Cable, Skye Longworth
Publikováno v:
eLife, Vol 13 (2024)
Antibodies are used in many areas of biomedical and clinical research, but many of these antibodies have not been adequately characterized, which casts doubt on the results reported in many scientific papers. This problem is compounded by a lack of s
Externí odkaz:
https://doaj.org/article/0b65acdfb7aa48e3af7059256f37ae20
Publikováno v:
F1000Research, Vol 12 (2024)
Midkine is a secreted protein that acts as a growth factor or cytokine involved in cell survival and inflammatory processes. It accumulates in amyloid plaques, which are hallmarks of Alzheimer’s Disease (AD). The reproducibility of Midkine research
Externí odkaz:
https://doaj.org/article/c30ab8b2fbfe4f2092198a5d29419ef1
Autor:
Carl Laflamme, Sara González Bolívar, Kathleen Southern, Riham Ayoubi, Maryam Fotouhi, Charles Alende
Publikováno v:
F1000Research, Vol 13 (2024)
Protein-glutamine gamma-glutamyltransferase 2 (TGM2) is a Ca2+ dependent enzyme that catalyzes transglutaminase cross-linking modifications. TGM2 is involved in various diseases, either in a protective or contributory manner, making it a crucial prot
Externí odkaz:
https://doaj.org/article/8a3705cc8de940a8b994d8b4c482cd2b
Publikováno v:
F1000Research, Vol 12 (2024)
Midkine is a secreted protein that acts as a growth factor or cytokine involved in cell survival and inflammatory processes. It accumulates in amyloid plaques, which are hallmarks of Alzheimer’s Disease (AD). The reproducibility of Midkine research
Externí odkaz:
https://doaj.org/article/a1e0ee004b4d4ea5808c172a1f070154
Autor:
Peter S. McPherson, Carl Laflamme, Kathleen Southern, Riham Ayoubi, Walaa Alshafie, Irina Shlaifer
Publikováno v:
F1000Research, Vol 12 (2024)
Sequestosome-1, encoded by the gene SQSTM1, functions as a bridge between ubiquitinated proteins and the proteasome or autophagosome, thereby regulating protein degradation pathways. Loss of Sequestosome-1 is hypothesized to enhance neurodegeneration
Externí odkaz:
https://doaj.org/article/e0a4a9de2d574260aa8ce1fb1d505856
Publikováno v:
F1000Research, Vol 12 (2024)
Tyrosine-protein kinase SYK, encoded by the SYK gene, is a non-receptor type protein kinase which mediates immune signal transduction through immunoreceptors. Tyrosine-protein kinase SYK expression has been associated with the development of various
Externí odkaz:
https://doaj.org/article/0cb1968de47941d199ea01723c886a61
Autor:
Peter S. McPherson, Carl Laflamme, Kathleen Southern, Donovan Worrall, Riham Ayoubi, Maryam Fotouhi
Publikováno v:
F1000Research, Vol 12 (2024)
A member of the RNA-binding protein family, T-cell intracellular antigen-1 (TIA1) regulates mRNA translation and splicing as well as cellular stress by promoting stress granule formation. Variants of the TIA1 gene have implications in neurogenerative
Externí odkaz:
https://doaj.org/article/fe309b255df34020b5aad6172fb19351
Autor:
Peter S. McPherson, Vera Ruíz Moleón, Carl Laflamme, Sara González Bolívar, Kathleen Southern, Riham Ayoubi, Maryam Fotouhi
Publikováno v:
F1000Research, Vol 12 (2023)
Rab1 is a highly conserved small GTPase that exists in humans as two isoforms: Rab1A and Rab1B, sharing 92% sequence identity. These proteins regulate vesicle trafficking between the endoplasmic reticulum (ER) and Golgi and within the Golgi stacks. R
Externí odkaz:
https://doaj.org/article/efcbd91ad54e4f25bbe209530704ef96
Publikováno v:
F1000Research, Vol 12 (2023)
Moesin is a cytoskeletal adaptor protein, involved in the modification of the actin cytoskeleton, with relevance to Alzheimer’s Disease. Well characterized anti-Moesin antibodies would benefit the scientific community. In this study, we have charac
Externí odkaz:
https://doaj.org/article/f86c2f68c0714b1b92db50693dbc62f3