Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Carl LaCerte"'
Autor:
Michelle A. Rudek, Judith E. Karp, John J. Wright, L. Austin Doyle, Jacqueline M. Greer, Joga Gobburu, Vijay Ivaturi, Carl LaCerte
Representative Individual Concentration versus Time Pharmacokinetic Profiles for Total or Unbound Flavopiridol Using Bolus (A) or Hybrid (B) Dosing Schemes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fcc5e7d0448d5b78adaf1f8c4ca7270
https://doi.org/10.1158/1078-0432.22466786
https://doi.org/10.1158/1078-0432.22466786
Autor:
Michelle A. Rudek, Judith E. Karp, John J. Wright, L. Austin Doyle, Jacqueline M. Greer, Joga Gobburu, Vijay Ivaturi, Carl LaCerte
Conditional Weighted Residuals versus Time or Predicted Concentration: Total Flavopiridol (A and C), Unbound Flavopiridol (B and D).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6417594c6e63340b161dc2eb706ec6cd
https://doi.org/10.1158/1078-0432.22466795.v1
https://doi.org/10.1158/1078-0432.22466795.v1
Autor:
Michelle A. Rudek, Judith E. Karp, John J. Wright, L. Austin Doyle, Jacqueline M. Greer, Joga Gobburu, Vijay Ivaturi, Carl LaCerte
Supplemental Tables 1-5 and upplemental Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15f8cdcda28548860789070653e1906d
https://doi.org/10.1158/1078-0432.22466804.v1
https://doi.org/10.1158/1078-0432.22466804.v1
Autor:
Michelle A. Rudek, Judith E. Karp, John J. Wright, L. Austin Doyle, Jacqueline M. Greer, Joga Gobburu, Vijay Ivaturi, Carl LaCerte
Observed versus Predicted Flavopiridol Concentrations: Total Individual (A), Unbound Individual (B), Total Population (C), or Unbound Population (D).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a86c65a2cdeb0073d6bad03283a958b
https://doi.org/10.1158/1078-0432.22466798.v1
https://doi.org/10.1158/1078-0432.22466798.v1
Autor:
Michelle A. Rudek, Judith E. Karp, John J. Wright, L. Austin Doyle, Jacqueline M. Greer, Joga Gobburu, Vijay Ivaturi, Carl LaCerte
Purpose: To elucidate any differences in the exposure–response of alvocidib (flavopiridol) given by 1-hour bolus or a hybrid schedule (30-minute bolus followed by a 4-hour infusion) using a flavopiridol/cytosine arabinoside/mitoxantrone sequential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d33ba9bfcc5d9061738eebd5e338beb
https://doi.org/10.1158/1078-0432.c.6526433.v1
https://doi.org/10.1158/1078-0432.c.6526433.v1
Autor:
Michelle A. Rudek, Judith E. Karp, John J. Wright, L. Austin Doyle, Jacqueline M. Greer, Joga Gobburu, Vijay Ivaturi, Carl LaCerte
Supplemental Figure 4. Visual Predictive Check (VPC) for Total or Unbound Flavopiridol Using Bolus or Hybrid Dosing Schemes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4347452b222ae63735c9b64576e0c25a
https://doi.org/10.1158/1078-0432.22466792
https://doi.org/10.1158/1078-0432.22466792
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 365:413-421
The farnesoid X receptor (FXR) is a nuclear receptor that regulates genes involved in bile acid homeostasis. FXR agonists, obeticholic acid (OCA) and chenodeoxycholic acid (CDCA), increase mRNA expression of efflux transporters in sandwich-cultured h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::884d2095a39c3598866b36f1f13c16c8
https://doi.org/10.1124/jpet.117.246033
https://doi.org/10.1124/jpet.117.246033
Autor:
Carl LaCerte, AF Hofmann, J.F. Marier, Nathalie H. Gosselin, Jeffrey E. Edwards, David Shapiro, T. Peyret
Publikováno v:
Clinical and Translational Science
Obeticholic acid (OCA), a semisynthetic bile acid, is a selective and potent farnesoid X receptor (FXR) agonist in development for the treatment of chronic nonviral liver diseases. Physiologic pharmacokinetic models have been previously used to descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d93ac41658881dfe4b9ebeda3c5508
https://pubmed.ncbi.nlm.nih.gov/27743502
https://pubmed.ncbi.nlm.nih.gov/27743502
Autor:
Janet Owens-Grillo, Saul J. Karpen, Yuanyuan Zhang, Leigh MacConell, Carl LaCerte, Jeffrey Edwards
Publikováno v:
Gastroenterology. 154:S-1212
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::106a119d17eeff1d26303e473b5ad1aa
https://doi.org/10.1016/s0016-5085(18)34003-4
https://doi.org/10.1016/s0016-5085(18)34003-4
Autor:
Barbara A. Parker, Michael Horowitz, Selena Doran, F. Carl Lacerte, F. Kim Chen, Christine Feinle-Bisset, F. Christian Weyer, Cameron W. Lush, Ian Chapman, Judith M. Wishart, F. Robyn Mckay, F. Colleen Burns
Publikováno v:
Obesity. 15:1179-1186
Objective: We previously reported that a single preprandial injection (120 μg) of pramlintide, an analog of the β-cell hormone amylin, reduced ad libitum food intake in obese subjects. To further characterize the meal-related effects of amylin sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c413669024cc1b3904930a8cf9fd12b
https://doi.org/10.1038/oby.2007.626
https://doi.org/10.1038/oby.2007.626