Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Carl Kadie"'
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 10, Pp 1879-1886 (2007)
The identification of T cell epitopes and their HLA (human leukocyte antigen) restrictions is important for applications such as the design of cellular vaccines for HIV. Traditional methods for such identification are costly and time-consuming. Recen
Externí odkaz:
https://doaj.org/article/15282638458b4eb587782ac0565c82ba
Autor:
Xiang Zhang, Wei Cheng, Jennifer Listgarten, Carl Kadie, Shunping Huang, Wei Wang, David Heckerman
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e35762 (2012)
Understanding the organization and function of transcriptional regulatory networks by analyzing high-throughput gene expression profiles is a key problem in computational biology. The challenges in this work are 1) the lack of complete knowledge of t
Externí odkaz:
https://doaj.org/article/6c3b8ada5bb84cd2af120c56aa23b8ef
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21591 (2011)
Understanding the role of genetic variation in human diseases remains an important problem to be solved in genomics. An important component of such variation consist of variations at single sites in DNA, or single nucleotide polymorphisms (SNPs). Typ
Externí odkaz:
https://doaj.org/article/ba3d96dda63a4adc9532af32ab8b518f
Autor:
Jonathan M Carlson, Zabrina L Brumme, Christine M Rousseau, Chanson J Brumme, Philippa Matthews, Carl Kadie, James I Mullins, Bruce D Walker, P Richard Harrigan, Philip J R Goulder, David Heckerman
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 11, p e1000225 (2008)
HIV avoids elimination by cytotoxic T-lymphocytes (CTLs) through the evolution of escape mutations. Although there is mounting evidence that these escape pathways are broadly consistent among individuals with similar human leukocyte antigen (HLA) cla
Externí odkaz:
https://doaj.org/article/e61b6ed8a25c42d0982ce1e881a1fc15
Autor:
Jennifer Listgarten, Zabrina Brumme, Carl Kadie, Gao Xiaojiang, Bruce Walker, Mary Carrington, Philip Goulder, David Heckerman
Publikováno v:
PLoS Computational Biology, Vol 4, Iss 2, p e1000016 (2008)
High-resolution HLA typing plays a central role in many areas of immunology, such as in identifying immunogenetic risk factors for disease, in studying how the genomes of pathogens evolve in response to immune selection pressures, and also in vaccine
Externí odkaz:
https://doaj.org/article/52541f9f88234552981074403c5c43c6
Autor:
Zabrina L Brumme, Chanson J Brumme, David Heckerman, Bette T Korber, Marcus Daniels, Jonathan Carlson, Carl Kadie, Tanmoy Bhattacharya, Celia Chui, James Szinger, Theresa Mo, Robert S Hogg, Julio S. G Montaner, Nicole Frahm, Christian Brander, Bruce D Walker, P. Richard Harrigan
Publikováno v:
PLoS Pathogens, Vol 3, Iss 8 (2007)
Externí odkaz:
https://doaj.org/article/cfd16983220b4d1e8f0efeed89e7df00
Autor:
Zabrina L Brumme, Chanson J Brumme, David Heckerman, Bette T Korber, Marcus Daniels, Jonathan Carlson, Carl Kadie, Tanmoy Bhattacharya, Celia Chui, James Szinger, Theresa Mo, Robert S Hogg, Julio S G Montaner, Nicole Frahm, Christian Brander, Bruce D Walker, P Richard Harrigan
Publikováno v:
PLoS Pathogens, Vol 3, Iss 7, p e94 (2007)
Despite the formidable mutational capacity and sequence diversity of HIV-1, evidence suggests that viral evolution in response to specific selective pressures follows generally predictable mutational pathways. Population-based analyses of clinically
Externí odkaz:
https://doaj.org/article/19de9ceb19fb40818ab5ac1b57c7dd0d
Publikováno v:
PLoS ONE, Vol 2, Iss 7, p e591 (2007)
Population structure can confound the identification of correlations in biological data. Such confounding has been recognized in multiple biological disciplines, resulting in a disparate collection of proposed solutions. We examine several methods th
Externí odkaz:
https://doaj.org/article/8efd1f7b5eb34c5db4e6226d3097d5bc
Autor:
Christine M. Rousseau, David W. Lockhart, Jennifer Listgarten, Stephen N. Maley, Carl Kadie, Gerald H. Learn, David C. Nickle, David E. Heckerman, Wenjie Deng, Christian Brander, Thumbi Ndung'u, Hoosen Coovadia, Philip J.R. Goulder, Bette T. Korber, Bruce D. Walker, James I. Mullins
Publikováno v:
AIDS Research & Human Retroviruses; Mar2009, Vol. 25 Issue 3, p297-303, 7p
Publikováno v:
Journal of Computational Biology; Jul2007, Vol. 14 Issue 6, p736-746, 11p